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Coronavirus.. outlook

Medfinder

Medfinder

Chemon 91
coconutcurry said:
A new mutation was identified:

"These data highlight the prospect of reinfection with antigenically distinct variants and may foreshadow reduced efficacy of current spike-based vaccines."

https://www.biorxiv.org/content/10.1101/2021.01.18.427166v1

This new mutation will make the vaccinations more or less useless. This is what many people feared. The virus keeps on mutating and we can't vaccinate the whole world population a couple of times every year.
Click to expand...

:jawdrop::peek:


Abstract
SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and may foreshadow reduced efficacy of current spike-based vaccines.

Competing Interest Statement
The authors have declared no competing interest.

Paper in collection COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

https://www.biorxiv.org/content/10.1101/2021.01.18.427166v1
 
armedoldhippy

armedoldhippy

Well-known member
Veteran
i am finding differing opinions on whether the mutations will render vaccines of less or no value. have seen NO definite answer, and am unsure of getting one...
 
coconutcurry

coconutcurry

High
That is still an unconfirmed information, but I don't expect to read next days everything will be fine. Maybe I'm too negative, but times are tough. If this mutation spreads, I fear we can develop new vaccinations and start to vaccinate all people again and the question is how many times we want to do that.

First time I advocate for a general compulsory vaccination. Simply because the virus can only get stopped, when you eliminate it. When only 80% of a population is vaccinated, the other 20% get infected and produce new mutations, which make the vaccination of the other 80% useless. We can't take the risk of new Corona mutation outbreaks again and again. How long do you want to do this?
 
G

Guest

Medscape reports Moderna is examining the reports of (more than a few) allergic reactions to the vaccine they put out.

Another article in the most recent e-publication, asking whether Doctors who provide misinformation should face disciplinary action. Depends, I'd say. Negligence? Honest mistake? Severity of negative outcomes, if any?

At any rate, the folks involved with the vax production (and distribution?) are sitting on a pile of immunity, unless MAYBE something more untoward than an 'Oops' is discovered.

And considering the vax reportedly doesn't keep persons from contracting or spreading the virus (my more recent understanding, and maybe incorrect), then the whole vax thing basically lessens symptoms for those who receive it, but brings about what can almost be described as a choreographed herd immunity plan for those the recipients of the vax encounter, who aren't yet vaccinated.

Sounds a lot like minimalist efforts toward prevention, maybe... or grasping at straws.
 
I

igrowone

Well-known member
Veteran
lot of approaches
J & J vax is different, it uses a adenovirus that has been engineered to be incapable of reproducing inside a cell
the virus is a delivery package of the spiky covid protein
may have some significant advantages, maybe increased immunity
time will tell
 
coconutcurry

coconutcurry

High
igrowone said:
interesting, there's a preliminary report by the pharma companies that antibodies from inoculated persons do neutralize the mutation from the UK

over on cnbc - https://www.cnbc.com/2021/01/20/cov...ikely-to-be-effective-against-uk-variant.html

who's right? I do not know
Click to expand...

I fear we have a missunderstanding. We are not talking about the UK mutation. We are not talking about mutation B.1.1.7, but about mutation 501Y.V2.

There are more than 12.000 known mutations going round. And this are only the mutations discovered. Only less mutations are dangerous, like the British one (B.1.1.7) or the South African one (E484K). This one (501Y.V2) is new.
 
G

Guest

igrowone said:
lot of approaches
J & J vax is different, it uses a adenovirus that has been engineered to be incapable of reproducing inside a cell
the virus is a delivery package of the spiky covid protein
may have some significant advantages, maybe increased immunity
time will tell
Click to expand...

Like another here, I've read ~ 4 mos. protection from antibodies resulting from having the virus, for many, and others have said 5 mos. to a year from vaccines, Though my question is, with the vax being out for the shorter duration as it has, how the hell would they even know, other than pulling numbers out of their butts?

My conclusion, for now, has been that with the rush of urgency, came the onset of optimism, whether earned, deserved, or not.

Sometimes running from the bear, a person can break a leg on the log they trip on.

edit: In which case the bear gets them anyway...
 
I

igrowone

Well-known member
Veteran
coconutcurry said:
I fear we have a missunderstanding. We are not talking about the UK mutation. We are not talking about mutation B.1.1.7, but about mutation 501Y.V2.

There are more than 12.000 known mutations going round. And this are only the mutations discovered. Only less mutations are dangerous, like the British one (B.1.1.7) or the South African one (E484K). This one (501Y.V2) is new.
Click to expand...
my mistake, too many covid viruses going around
getting a little too close to the 12 monkeys movie
disease drove everyone underground to eke out a living
 
coconutcurry

coconutcurry

High
Just had a look at Wikipedia:
https://en.wikipedia.org/wiki/Variants_of_SARS-CoV-2

501.V2 variantMain article: 501.V2 variant
On 18 December 2020, the 501.V2 variant, also known as 501.V2, 20C/501Y.V2 or lineage B.1.351,[22] was first detected in South Africa and reported by the country's health department.[29] Researchers and officials reported that the prevalence of the variant was higher among young people with no underlying health conditions, and by comparison with other variants it is more frequently resulting in serious illness in those cases.[30][31] The South African health department also indicated that the variant may be driving the second wave of the COVID-19 epidemic in the country due to the variant spreading at a more rapid pace than other earlier variants of the virus.[29][30]
Scientists noted that the variant contains several mutations that allow it to attach more easily to human cells because of the following three mutations in the receptor-binding domain (RBD) in the spike glycoprotein of the virus: N501Y,[29][32] K417N, and E484K.[33][34] The N501Y mutation has also been detected in the United Kingdom.[29][35]
Click to expand...
First time I found the South African strain in the media was 22th December:
https://www.icmag.com/ic/showthread.php?p=9078087#post9078087


edit: I am glad that the bearer of bad news is no longer beheaded these days
 
mexcurandero420

mexcurandero420

See the world through a puff of smoke
Veteran
The South- African variant gives other symptoms, more stomach and belly problems, from what I read about a woman who had this variant in the Netherlands.
 
Medfinder

Medfinder

Chemon 91
Coronavirus Cases:
97,477,830
view by country
Deaths:
2,087,156
Recovered:
70,027,926
ACTIVE CASES
25,362,748
Currently Infected Patients
25,250,758 (99.6%)
in Mild Condition

111,990 (0.4%)
Serious or Critical


Show Statistics
CLOSED CASES
72,115,082
Cases which had an outcome:
70,027,926 (97%)
Recovered / Discharged

2,087,156 (3%)
Deaths:comfort:
 
G

Guest

Last edited:
mexcurandero420

mexcurandero420

See the world through a puff of smoke
Veteran
moose eater said:
MedScape- Pfizer Vax Seems to Work on Variant

https://www.medscape.com/viewarticl...121_MSCPEDIT&uac=348476AZ&impID=3142427&faf=1

-----------------------------------------------
Medscape

Johnson & Johnson Vax Trial Results

(and other vax statuses)

https://emedicine.medscape.com/arti...edit_infd&uac=&spon=3&impID=2947343&faf=1&#a2
-----------------------------------------------

The 29th death from C-19 in Alaska, 2 days ago(?) was a Fairbanks man in his 60s. Getting closer to home.
Click to expand...

We also have a German variant at the moment in investigation.That virus is faster than us.
 
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