from: The Terpenes of Cannabis, Their Aromas, and Effects
"It's not just about THC or CBD. Cannabis is a mix of many different compounds. Most of them fall into three categories: cannabinoids, terpenoids, and flavanoids. Each of these compounds can significantly modify the therapeutic benefits of the plant. There are hundreds of different chemical combinations each producing a different effect. Meschler and Howlett (1999) discussed several mechanisms by which terpenoids modulate THC activity. For instance, some terpenoids bind to cannabinoid receptors sequestering THC by perturbing annular lipids surrounding the receptor, or by increasing the fluidity of neuronal membranes, and increasing cell wall permeability. Other terpenoids alter the signal by remodeling G-proteins. And then there are terpenoids that alter the pharmacokinetics of THC itself. Terpenoids may also act on other receptors and neurotransmitters. Some terpenoids act as serotonin uptake inhibitors (as does Prozac), some enhance norepinephrine activity (as do tricyclic antidepressants), some increase dopamine activity (as do monoamine oxidase inhibitors and bupropion), and some augment GABA (as do baclofen and the benzodiazepines)."
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So perhaps most of the various "potency" effects from the many, many cannabis strains has more to do with the types and ratios of terpenoids present in a particular strain rather than the percent of cannabinoids like THC.
If some terps act like Prozac and inhibit serotonin uptake, you can be damned sure that the weed exhibiting this will be seen as "couchlock" and weed that has terps that enhance norepinephrine activity will be seen as "racy, cerebral, and high".
.........and all because of the terpenoids doing their thing in the cannabis chemistry mix
"It's not just about THC or CBD. Cannabis is a mix of many different compounds. Most of them fall into three categories: cannabinoids, terpenoids, and flavanoids. Each of these compounds can significantly modify the therapeutic benefits of the plant. There are hundreds of different chemical combinations each producing a different effect. Meschler and Howlett (1999) discussed several mechanisms by which terpenoids modulate THC activity. For instance, some terpenoids bind to cannabinoid receptors sequestering THC by perturbing annular lipids surrounding the receptor, or by increasing the fluidity of neuronal membranes, and increasing cell wall permeability. Other terpenoids alter the signal by remodeling G-proteins. And then there are terpenoids that alter the pharmacokinetics of THC itself. Terpenoids may also act on other receptors and neurotransmitters. Some terpenoids act as serotonin uptake inhibitors (as does Prozac), some enhance norepinephrine activity (as do tricyclic antidepressants), some increase dopamine activity (as do monoamine oxidase inhibitors and bupropion), and some augment GABA (as do baclofen and the benzodiazepines)."
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> ****** <<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<<
So perhaps most of the various "potency" effects from the many, many cannabis strains has more to do with the types and ratios of terpenoids present in a particular strain rather than the percent of cannabinoids like THC.
If some terps act like Prozac and inhibit serotonin uptake, you can be damned sure that the weed exhibiting this will be seen as "couchlock" and weed that has terps that enhance norepinephrine activity will be seen as "racy, cerebral, and high".
.........and all because of the terpenoids doing their thing in the cannabis chemistry mix