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The Original O'l Farts Club.

SubGirl

SubGirl

Well-known member
Premium user
✓
420club
bigsur51 said:
great questions Unca….you are entering into the Realm of the World of Psychedelia….

closely linked to one’s pineal gland and a tool in the decalcifying of the pineal gland


What is a Psychedelic Drug?​

The term psychedelic was created by English psychologist and researcher Humphry Osmond. He derived it from the Greek words for mind or soul (psyche) and show (deloun) to describe the effect LSD had on the mind. Osmond first used the word in a presentation he gave at the New York Academy of Sciences in 1957.1

Basically, there are two ways to figure out if a drug is psychedelic. The first is based on its receptor binding. The second is to compare the effects of the drug to what are considered psychedelic effects. If a compound passes the test for either or both, then it is psychedelic.

In terms of receptors, scientists classify a drug as psychedelic if it binds to serotonin 5-HT2A receptors (5-HT2AR) as an agonist or partial agonist2–4 (these are typically tryptamine compounds which are chemically similar to serotonin). The hallucinogenic effects of agonist binding are mediated via the 5-HT2AR receptor-coupled signaling pathway.2,3 This pathway is not entirely understood, but researchers theorize that it involves activation of the enzyme phospholipase C leading to the formation of inositol phosphates and diglycerol (signaling molecules) which causes the release of calcium ions from the endoplasmic reticulum in the cell. The possibility also exists that other serotonin receptors may be involved in the overall psychedelic experience of a user.

Interestingly, the effects of psychedelic drugs are highly variable and may not be dose-dependent.4 With LSD, for example, low doses (about <100 µg) may cause some distortion of cognitive and sensory processes with the person remaining aware that the drug is causing the effects. Higher doses may “…transport the user to an alternate reality, where they lose contact with their everyday environment.” These are the transcendent or mystical experiences that represent states of consciousness that are profoundly altered from reality.

From a medical standpoint, it is now understood by researchers that having a mystical experience results in a dramatic improvement for patients using psychedelic-assisted therapy.5–8 However, the mystical phenomenon can occur when using almost any dose of a psychedelic as long as the set and setting have been optimized to promote an altered state of consciousness.4

THC and other compounds in cannabis that have been tested elicit their effects by binding as agonists or partial agonists on the cannabinoid receptors CB1 and CB2. Like the serotonin receptors, cannabinoid receptors belong to the G protein-coupled receptor (GPCR) family.

When it comes to 5-HT2AR, current research indicates THC binding may have a role in the development of schizophrenia in young adults with long-term cannabis use.9 This study found that in young mice, long-term exposure to THC “…induced a pro-hallucinogenic molecular conformation of the 5-HT2AR.” The researchers also observed “…exacerbated schizophrenia-like responses…” in the mice. These observations of the modification of 5-HT2AR by THC is not only a ground-breaking finding but it also adds to the evidence of cannabis being a psychedelic drug based on receptor binding.
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Scientist Walt, Scientist. 😳
 
Capt.Ahab

Capt.Ahab

Feeding the ducks with a bun.
Veteran
Looks like rain is coming this morning so I slept in today.
Good Morning , fellow Old Farts.
GEaICGWWMAAP5vs.jpg
 
Sun&Soil

Sun&Soil

Well-known member
bigsur51 said:
as far as the pain killer question I can only speak from my experience and specifically my experience in regards to pain relief from chronic migraines…

it does help me deal with a migraine, somewhat similar to cannabis in that I still have the pain , but with mushrooms , I can “ move” the pain into another compartment of my brain where it is out of sight out of mind…

i trade the pain for a psychedelic experience which usually includes copious amounts of smiles and laughs , lots of colors , and some hallucinations depending on how much I consume…

smoking weed and consuming mushrooms create an entourage effect , a synergy and in my opinion , the two were made for each other….
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I personally never enjoyed bringing cannabis into my tripping experiences. It tends to slow the pace down to much for me. I really enjoy when my loops are fast paced and short in structure. Towards the end of a trip when the loops have naturally elongated and slowed then I will consider bringing the two together.

My brain moves much faster then the rest of myself when it's in a sober state. Psychedelics tends to bring myself up to speed with my brain which in turn allows me to experience a balance of time and space for a brief period of 4-5 hours. The cannabis throws that balance off.

I am sure this post will be understood by very few, but I assure you I am not ready for the loony bin, yet.
 
bigsur51

bigsur51

On a mailtrain.
Premium user
Veteran
420club
Sun&Soil said:
I personally never enjoyed bringing cannabis into my tripping experiences. It tends to slow the pace down to much for me. I really enjoy when my loops are fast paced and short in structure. Towards the end of a trip when the loops have naturally elongated and slowed then I will consider bringing the two together.

My brain moves much faster then the rest of myself when it's in a sober state. Psychedelics tends to bring myself up to speed with my brain which in turn allows me to experience a balance of time and space for a brief period of 4-5 hours. The cannabis throws that balance off.

I am sure this post will be understood by very few, but I assure you I am not ready for the loony bin, yet.
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it is a difficult task for me to articulate a psychedelic trip

how does one describe feeling , tasting , smelling , and being the color orange?….

my brain is fast….spinning 90 mph when my feet hit the floor….the cannabis and shrooms bring it down to a more manageable pace…🏄‍♀️
 
J

jokerman

Well-known member
Premium user
bigsur51 said:
as far as the pain killer question I can only speak from my experience and specifically my experience in regards to pain relief from chronic migraines…

it does help me deal with a migraine, somewhat similar to cannabis in that I still have the pain , but with mushrooms , I can “ move” the pain into another compartment of my brain where it is out of sight out of mind…

i trade the pain for a psychedelic experience which usually includes copious amounts of smiles and laughs , lots of colors , and some hallucinations depending on how much I consume…

smoking weed and consuming mushrooms create an entourage effect , a synergy and in my opinion , the two were made for each other….
Click to expand...
Its a good time for some sugar so to speak...☝️😊
 
oldfogey8

oldfogey8

Well-known member
SubGirl said:
These are golden teachers and the only kind so far I’ve tried. Maybe will try something else the next round. I love growing them
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I tried growing PE mushrooms in addition to GT. They seem more finicky. They are more powerful(or mine were). For Microdosing, I don’t think the more potent strain is necessary. Probably if someone were growing for a customer, having something with more kick would be a marketing trick but for self medication, I will be going with the GT from here on out(if I grow them again).

Edit: the PE were more finicky than the Golden Teacher. My post seemed to not really say that
 
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