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howmany people here dont trust the vaccine or covid

buzzmobile

Well-known member
Veteran
Columbus Omnicrom

30 years have passed since Columbus and The Institute of Welding of Paris collaborated on a research study which lead to obtaining patents on Cyclex and Nivacrom alloys. Today marks a new milestone in the history of high-performance alloys. Today we present OMNICROM.

OMNICROM rules!
 

mexcurandero420

See the world through a puff of smoke
Veteran
Maybe I missed something, but I've never read a reputable quote wherein Bill Gates claimed to be a vaccine expert, virologist, or even a decent pastry chef.

But I -did- read that the FDA and CDC had approved the vaccine boosters for young folks under 18.

By the way, the 3 members of my family under this roof have all had at least 2, and some of us 3, vaccines. And the two who lack their 3rd jab are receiving them tomorrow... along with a flu vaccine.

So far no one with any medical credibility and training has told us that we're now damaged, destined to perish, or that the blonde, blue-eyed cave women you seem to be referring to are no longer interested in the semen of the male members of our family.

Not sure what you might do to lower the caliber of your 'medical information' you post here; I've read more astute, accurate, and credible research on outhouse walls.... often with better grammar and punctuation.

Some of the bullshit I read at this site reminds me of the folks who used to (and some of them still do) argue that cannabis use in/by younger persons, especially males, leads to developmental deficiencies and mental illness... I frequently debated some of those folks during numerous legalization efforts, but frankly, I'm glad that most of them hadn't read tripe like has been posted at this site for the last 19 months since the Pandemic began. If they had, weed might still be illegal here. Just sayin'..

Hopefully all goes well then with the flu vaccine in combination with the boosters.Till now I haven't seen any goods from those vaccines.Youngsters dropping dead on the field or end up in the hospital with myocarditis.Since this year we see a huge excess mortality rate compared with last year when the pandemic started.Nursery homes outbreaks while they all are vaccinated and the government still telling to take the booster.Btw my niece took the booster, but got infected again and felt quite ill with a bloody headache for more then a week.
What I know now that those vaccines blocks your non-specific defense and the funny thing is that vitamin D increases your non-specific defense in other words make it stronger, that's why people with a high vitamin D level doesn't have much trouble with Covid, but that information is not given by the FDA & CDC.
 

Three Berries

Active member
If the Vaccine Is So Great, Why Are So Many People Dropping Dead?

https://townhall.com/columnists/way...icus-overwhelmed-from-coast-to-coast-n2600456

The COVID-19 vaccines appear to be causing a global health disaster. There are so many warnings from all around the world. I'll list just a few in this column. But the U.S. media remains silent. They're as quiet as a church mouse. Why?

All over America, and all over the world, cardiac arrest, heart inflammation and heart attack deaths are exploding. Young athletes are dropping right on the field; star soccer players in Europe are dropping dead in the middle of games; referees, coaches and even fans in the stands are having cardiac emergencies. It's something no one has ever seen before. It's an epidemic.

What do all these victims have in common? They've all been vaccinated.
 

Three Berries

Active member
2tKqB64.png
 

BudToaster

Well-known member
Veteran
from MedPage Today:
New research suggests that COVID-19 can infiltrate and infect fat cells in addition to immune cells, possibly explaining why people with overweight and obesity are more likely to experience severe symptoms. (New York Times)

and a comment to this:

Fred_Cowan • 5 hours ago
“COVID-19 can infiltrate and infect fat cells in addition to immune cells.”

COVID-19 has both ACE2 receptor infection and Fc receptor (FcR) antigen antibody immune complex ligand mediated inflammation. Both receptors are found in abundance on fat cells and associated macrophage and are implicated in COVID-19 inflammatory pathology, a microenvironment for the inflammatory cytokine “perfect storm.”

Association of high level gene expression of ACE2 in adipose tissue with mortality of COVID-19 infection in obese patients. Obes Med. 2020 Sep; 19: 100283. Published online 2020 Jul 18. doi: 10.1016/j.obmed.2020.100283 https://www.ncbi.nlm.nih.go...

Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes. Biochem Biophys Res Commun. 2006 Apr 28;343(1):43-8. doi: 10.1016/j.bbrc.2006.02.114. Epub 2006 Feb 28. https://pubmed.ncbi.nlm.nih...

https://opastonline.online/...

so, follow the FDA/CDC/NIH guidelines to loose weight to protect against getting damaged by covid ... just kidding, there is no guidance from any of those folks about getting healthy or how to do it.
 

flylowgethigh

Non-growing Lurker
ICMag Donor
And needlessly spent thousands of dollars doing it.

By buying seeds, tents, lights, etc? Supporting those who support us, while saving a bunch over paying a farmer? Those guys on the hill be wishing those thousands were being spent.

Packs were up to 18 when the stimmy first hit. I think that sold a lot of lights.
 

mexcurandero420

See the world through a puff of smoke
Veteran
 A renowned virologist and former senior officer of the Bill and Melinda Gates Foundation recently warned against the dangers of the experimental COVID-19 gene-transfer vaccines, encouraged the un-jabbed to “stay unvaccinated,” and predicted an inevitable “collapse of our health system” due to health complications in the vaccinated.

Dr. Geert Vanden Bossche, who once worked as a senior program manager for the Global Alliance for Vaccines and Immunization (GAVI) and has been considered one of the most talented vaccine creators in the world, issued a video “Message to Austria” on November 20 to coincide with a large rally in Vienna opposing new lockdown measures.

As a first priority, he advised the public, “Never, Ever — allow anything, or anybody, to interfere or suppress your innate immune system,” which is the first line of defense human beings have to fight off all infections.

According to Vanden Bossche, the “vaccine antibodies,” which are induced by the current COVID-19 vaccines, suppress innate immunity and they “cannot substitute for it” since they quickly wane in their effectiveness and cannot prevent infection or transmission of the virus.

Thus, these experimental injections, in contrast to innate immunity, “do not contribute to herd immunity,” he said.

Vaccinating children ‘an absoluteno go!’

This reality is most important in the case of children whose “innate immunity can easily be suppressed by vaccinal antibodies” since their “antibodies are so young and so naïve that they can easily be outcompeted by vaccinal antibodies,” he said.

And since children are protected from many diseases by their innate immunity, including COVID-19, its suppression by these vaccines exposes them to many more dangers, and “could even lead to autoimmune diseases,” the expert warned.

Therefore, injecting children with these biological agents “is an absoluteno go!” the virologist said. “We cannot vaccinate our children with these vaccines.”

Turning his attention to the adult “vaccinees,” those who have been vaccinated, the specialist in microbiology said the suppression of innate immunity has already shown itself to be a problem in this population. “They are indeed going to have a difficult time to control a number of diseases,” including COVID-19.

Yet, since their innate antibodies have previously been trained through years of adapting and maturing, he said “they are usually more resilient to the vaccinal antibodies” than those of children.

However, this resilience can be further deteriorated by additional shots, and thus Vanden Bossche warns that giving these jabbed individuals boosters “is absolutely insane! What this will do is just further increase the immune pressure of the vaccinal antibodies on their innate immunity.” Thus, booster shots are “absolute nonsense! It is dangerous and should not be done!”

To the un-jabbed: ‘For God’s sake, stay unvaccinated!’

As for the unvaccinated, the Belgian physician described why they would fare much better, first breaking them down into three categories:
  1. Those who have experienced no symptoms, who are “most likely simply protected by their innate antibodies;”
  2. Those who have experienced mild symptoms, not having to stay in bed for any time; and
  3. Those who recovered from the disease and may have even had a severe case of it.
Due to what he called the “high infectious pressure” of the Delta variant, the respective innate immunity systems of these unvaccinated may now have to struggle a bit more, and thus the first category may experience mild symptoms, the second, moderate, and the third may have “some higher susceptibility to some other diseases. For example, influenza or the common cold.”

“But very, very importantly, all are protected,” he said. “They all are still protected against severe disease and the majority of them will be protected against very mild or moderate disease.”

This is the case, especially, the virologist said, since COVID-19 “is not a disease of healthy people. People who are in good health have a healthy innate immune system that can deal with a number of respiratory viruses without any problem. These people are not only protected against the disease, but they can even in many cases prevent infection.”

Vaccinees ‘serving as a kind of breeding ground for the virus’

Therefore, in order to maintain their healthy innate immune system as protection against COVID-19 and many other diseases, Dr. Vanden Bossche offered the following three requirements to the unvaccinated:
  1. “For God’s sake, stay unvaccinated! They should stay unvaccinated;”
  2. “Take care of their innate immunity, meaning they should take care of their health … if you do this and you are unvaccinated, you will be spared from severe disease without any vaccine. On the contrary, the vaccine would do the opposite;” and
  3. Those with comorbidities or underlying diseases “should be careful about contacts.”
For this third category of the more vulnerable, the physician said, “This is not to discriminate against the vaccinees, but [the un-jabbed] should especially avoid contact with vaccinees at this point in time.

“Vaccinees are now the people, and there is no doubt about this, who are really serving as a kind of breeding ground for the virus,” he said. “We need to have an extra protection for those who have underlying diseases. Do not vaccinate them, but in fact prevent them from being exposed to high infectious pressure.”

Health issues in the vaxxed ‘will inevitably lead to a collapse of our health system’

He encouraged his Austrian listeners that the only fight they have is “the fight for your health, [in] not getting vaccinated.” In accomplishing this, all of the other measures will not be sustainable.

Though he expressed great concern for “the vaccinees,” stating “we need to help them as much as we can because they will need extensive treatment in many cases,” he observed that the percentage of this group now being hospitalized “is now steadily increasing. Whereas more and more, with training of the innate immune system, with more exposure to the virus, more and more non-vaccinated people get protected.”

“This will lead inevitably — and I am not a doomsday preacher — but this will inevitably lead to a collapse of our health system. It cannot be otherwise,” he said.

‘Strength is found in serenity’

However, in closing, the virologist had a hopeful message, stating the lockdown measures “are not sustainable” and cannot last “for a long time.” He encouraged them to “stay calm,” sharing a German saying that translates, “Strength is found in serenity.”

https://www.lifesitenews.com/news/r...tem-due-to-complications-from-covid-vaccines/

Just take extra vit D3, K2, zinc and selenium to give your immune system a boost, unless you're having a kidney disease, take anticoagulants on prescription, having an autoimmune disease etc.
 

Amynamous

Active member
If the Vaccine Is So Great, Why Are So Many People Dropping Dead?

https://townhall.com/columnists/way...icus-overwhelmed-from-coast-to-coast-n2600456

The COVID-19 vaccines appear to be causing a global health disaster. There are so many warnings from all around the world. I'll list just a few in this column. But the U.S. media remains silent. They're as quiet as a church mouse. Why?

All over America, and all over the world, cardiac arrest, heart inflammation and heart attack deaths are exploding. Young athletes are dropping right on the field; star soccer players in Europe are dropping dead in the middle of games; referees, coaches and even fans in the stands are having cardiac emergencies. It's something no one has ever seen before. It's an epidemic.

What do all these victims have in common? They've all been vaccinated.

Perhaps the other thing they had in common was a covid infection? The delta variant has a very high transmissibility factor and covid 19 can cause all of the same issues being attributed to the vaccines. Attributing these health issues to the vaccines without providing proof that the vaccine is actually the cause is irresponsible.
 

Amynamous

Active member
 A renowned virologist and former senior officer of the Bill and Melinda Gates Foundation recently warned against the dangers of the experimental COVID-19 gene-transfer vaccines, encouraged the un-jabbed to “stay unvaccinated,” and predicted an inevitable “collapse of our health system” due to health complications in the vaccinated.

Dr. Geert Vanden Bossche, who once worked as a senior program manager for the Global Alliance for Vaccines and Immunization (GAVI) and has been considered one of the most talented vaccine creators in the world, issued a video “Message to Austria” on November 20 to coincide with a large rally in Vienna opposing new lockdown measures.

As a first priority, he advised the public, “Never, Ever — allow anything, or anybody, to interfere or suppress your innate immune system,” which is the first line of defense human beings have to fight off all infections.

According to Vanden Bossche, the “vaccine antibodies,” which are induced by the current COVID-19 vaccines, suppress innate immunity and they “cannot substitute for it” since they quickly wane in their effectiveness and cannot prevent infection or transmission of the virus.

Thus, these experimental injections, in contrast to innate immunity, “do not contribute to herd immunity,” he said.

Vaccinating children ‘an absoluteno go!’

This reality is most important in the case of children whose “innate immunity can easily be suppressed by vaccinal antibodies” since their “antibodies are so young and so naïve that they can easily be outcompeted by vaccinal antibodies,” he said.

And since children are protected from many diseases by their innate immunity, including COVID-19, its suppression by these vaccines exposes them to many more dangers, and “could even lead to autoimmune diseases,” the expert warned.

Therefore, injecting children with these biological agents “is an absoluteno go!” the virologist said. “We cannot vaccinate our children with these vaccines.”

Turning his attention to the adult “vaccinees,” those who have been vaccinated, the specialist in microbiology said the suppression of innate immunity has already shown itself to be a problem in this population. “They are indeed going to have a difficult time to control a number of diseases,” including COVID-19.

Yet, since their innate antibodies have previously been trained through years of adapting and maturing, he said “they are usually more resilient to the vaccinal antibodies” than those of children.

However, this resilience can be further deteriorated by additional shots, and thus Vanden Bossche warns that giving these jabbed individuals boosters “is absolutely insane! What this will do is just further increase the immune pressure of the vaccinal antibodies on their innate immunity.” Thus, booster shots are “absolute nonsense! It is dangerous and should not be done!”

To the un-jabbed: ‘For God’s sake, stay unvaccinated!’

As for the unvaccinated, the Belgian physician described why they would fare much better, first breaking them down into three categories:
  1. Those who have experienced no symptoms, who are “most likely simply protected by their innate antibodies;”
  2. Those who have experienced mild symptoms, not having to stay in bed for any time; and
  3. Those who recovered from the disease and may have even had a severe case of it.
Due to what he called the “high infectious pressure” of the Delta variant, the respective innate immunity systems of these unvaccinated may now have to struggle a bit more, and thus the first category may experience mild symptoms, the second, moderate, and the third may have “some higher susceptibility to some other diseases. For example, influenza or the common cold.”

“But very, very importantly, all are protected,” he said. “They all are still protected against severe disease and the majority of them will be protected against very mild or moderate disease.”

This is the case, especially, the virologist said, since COVID-19 “is not a disease of healthy people. People who are in good health have a healthy innate immune system that can deal with a number of respiratory viruses without any problem. These people are not only protected against the disease, but they can even in many cases prevent infection.”

Vaccinees ‘serving as a kind of breeding ground for the virus’

Therefore, in order to maintain their healthy innate immune system as protection against COVID-19 and many other diseases, Dr. Vanden Bossche offered the following three requirements to the unvaccinated:
  1. “For God’s sake, stay unvaccinated! They should stay unvaccinated;”
  2. “Take care of their innate immunity, meaning they should take care of their health … if you do this and you are unvaccinated, you will be spared from severe disease without any vaccine. On the contrary, the vaccine would do the opposite;” and
  3. Those with comorbidities or underlying diseases “should be careful about contacts.”
For this third category of the more vulnerable, the physician said, “This is not to discriminate against the vaccinees, but [the un-jabbed] should especially avoid contact with vaccinees at this point in time.

“Vaccinees are now the people, and there is no doubt about this, who are really serving as a kind of breeding ground for the virus,” he said. “We need to have an extra protection for those who have underlying diseases. Do not vaccinate them, but in fact prevent them from being exposed to high infectious pressure.”

Health issues in the vaxxed ‘will inevitably lead to a collapse of our health system’

He encouraged his Austrian listeners that the only fight they have is “the fight for your health, [in] not getting vaccinated.” In accomplishing this, all of the other measures will not be sustainable.

Though he expressed great concern for “the vaccinees,” stating “we need to help them as much as we can because they will need extensive treatment in many cases,” he observed that the percentage of this group now being hospitalized “is now steadily increasing. Whereas more and more, with training of the innate immune system, with more exposure to the virus, more and more non-vaccinated people get protected.”

“This will lead inevitably — and I am not a doomsday preacher — but this will inevitably lead to a collapse of our health system. It cannot be otherwise,” he said.

‘Strength is found in serenity’

However, in closing, the virologist had a hopeful message, stating the lockdown measures “are not sustainable” and cannot last “for a long time.” He encouraged them to “stay calm,” sharing a German saying that translates, “Strength is found in serenity.”

https://www.lifesitenews.com/news/re...ovid-vaccines/

Just take extra vit D3, K2, zinc and selenium to give your immune system a boost, unless you're having a kidney disease, take anticoagulants on prescription, having an autoimmune disease etc.


counterpoint:

https://www.deplatformdisease.com/bl...ossches-claims

Addressing Geert Vanden Bossche’s Claims


Mar 15
Written By Edward Nirenberg
The short version: Geert Vanden Bossche has recently published a letter in which he argues that the vaccination campaign against COVID-19 is going to precipitate a public health disaster because the vaccines will select for viral variants that can escape their protection and drive them towards higher virulence. His claims are speculative, he offers no evidence to support his arguments, and makes several comments which are blatantly incorrect. The core of his argument relies on the assumption that COVID-19 vaccines do not have a significant effect on transmission. This has been repeatedly confirmed to be false in multiple studies. Furthermore, even if his assumptions about the effects of the vaccine on transmission are true, his conclusions are incorrect based on established precedent from Marek’s disease, a viral illness of birds with a vaccine that does not strongly affect transmission- but it still shows meaningful public health benefits in the populations of chickens where it is used. The vaccines will absolutely be critical to ending the pandemic, and fortunately the modular nature of the technology allows for rapid reformulation and adjustment as necessary (and thus far, though precautions are being taken with novel variants to produce vaccines specific to their set of problematic mutations, there isn’t significant enough evidence to suggest that total reformulation of the vaccines is needed), but no issues raised in this letter warrant a re-evaluation of our current COVID-19 vaccination policy.
I won’t be addressing the contents of Dr. Vanden Bossche’s resume as it’s irrelevant to the fact that he is currently making unsupportable claims, but for those seeking a backgrounder on the subject, Dr. Iannelli has graciously obliged. I also won’t be linking to his original letter.

I’ll be blunt: there is very little within this letter that is even close to being correct, and there is almost no evidence presented to support any of its claims. I’ll now go through it point-by-point to explain where it’s wrong.
It's not exactly rocket science, it’s a basic principle taught in a student’s first vaccinology class: One shouldn’t use a prophylactic vaccine in populations exposed to high infectious pressure (which is now certainly the case as multiple highly infectious variants are currently circulating in many parts of the world).​


There is no such principle. It in fact directly goes against current policies for responding to outbreaks of e.g. measles, mumps, meningococcal disease, etc. and more generally is directly at odds with the incredibly effective ring vaccination strategy.
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Screen+Shot+2021-03-15+at+2.42.47+PM.png
Wang Z, Schmidt F, Weisblum Y, et al. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature [Internet] 2021;Available from: https://www.nature.com/articles/s41586-021-03324-6.pdf Figure 1i; note that in some individuals there is preserved antibody neutralization with the constellation of problematic mutations in the spike protein that are noted to reduce binding affinity. Red circles indicate that the patient received Pfizer’s vaccine while white circles indicate Moderna’s vaccine.
To fully escape selective immune pressure exerted by vaccinal antibodies, Covid-19, a highly mutable virus, only needs to add another few mutations in its receptor-binding domain​


COVID-19 is a clinical syndrome, and therefore incapable of mutating; the virus causing it is SARS-CoV-2.
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Screen+Shot+2021-03-15+at+3.10.51+PM.png
Murphy K, Weaver C. Janeway’s Immunobiology. 9th ed. Boca Raton, FL: CRC Press; 2016. Table 10.27

This claim remains to be substantiated and in fact has considerable evidence against it. While it’s true that variants of concern demonstrate reduced antibody neutralization, we do not have an absolute correlate for which antibody levels would be protective and therefore the meaning of this is hard to determine. The antibody titers induced by the vaccines are MUCH higher than those seen with infection, and we see hallmarks of memory responses induced by these vaccines from even a single dose, meaning that even though there is a drop in neutralization, it may not mean a loss in protection. Novavax’s recent Phase 3 clinical trial did show reduced efficacy against B.1.351 which has a constellation of problematic mutations that manage to reduce antibody binding affinity and also increase affinity for ACE2, however the key point is that: no one in the vaccinated group developed severe disease. The simplest explanation I can propose for this is: there is no significant change to the T cell response with the variants in either recovered or vaccinated individuals and T cell responses are critical determinants of patient clinical course. Importantly, it is possible that vaccines may simply need a bit more time for high-affinity antibodies against the variants to be generated (see “affinity maturation”; also addressed in more detail in the context of HIV here). It is also worth noting that in studies examining the antibody responses to variants of concern, some individuals do already exhibit antibodies that cross-neutralize problematic strains at similar levels. Nonetheless, it is not as though we are sitting idle and allowing SARS-CoV-2 to accumulate escape mutations. For one thing, Moderna has completed enrollment of a phase 1 trial for a variant-specific mRNA vaccine targeting B.1.351 which bears a constellation of concerning mutations in its spike protein shown to dramatically reduce antibody binding. Evidence has already confirmed that antibodies against B.1.351 cross-neutralize with ancestral variants. Pfizer and Novavax are also working on updated vaccines against the variants of concern in case they may be needed. Critically, it would seem that immunocompromised individuals are critical in the evolution of problematic SARS-CoV-2 variants, and thus protecting them from infection is imperative (and a vaccination strategy -our current vaccination strategy- will play a key role in that, but I’ll revisit this shortly when discussing evidence for the effects of the vaccines on transmission).
Not only would people lose vaccine-mediated protection but also their precious, variant-nonspecific (!), innate immunity will be gone (this is because vaccinal antibodies outcompete natural antibodies for binding to Covid-19, even when their affinity for the viral variant is relatively low).​


This is absolute, unvarnished nonsense. Bossche is referencing the production of natural IgM, which is generated by B1-B cells as a stopgap measure against infections until more potent responses can be initiated; these antibodies are polyreactive, nonspecific, and critically: constitutively produced. They are always present for as long as B1-B cells generating them live. IgM is pentameric and thus even though it has lower affinity than antibodies that have had the opportunity to evolve superior binding affinity, it can compensate with the fact that it has 10 binding sites instead of 2. However, IgG antibodies bear many of the same effector functions (actually, they tend to be better at many of them, as Table 10.27 shows) and they can diffuse into extravascular sites unlike IgM. Principally, antibodies against SARS-CoV-2 could be of value if they are neutralizing. Bossche presents no evidence to support that natural IgM is neutralizing (rather than just binding) SARS-CoV-2.

Bossche subsequently goes on to define:
*NACs: Natural asymptomatic carriers ; refers to subjects who do not develop any clinical symptoms at all, or develop at most mild (involving upper respiratory airways only), after PRIMARY CoV infection

**nonNACs: Relates to subjects who develop severe Covid-19 symptoms after PRIMARY infection​


Firstly, an asymptomatic patient does not develop mild symptoms. This is not what asymptomatic means. An asymptomatic patient does not develop ANY symptoms. There is another term -paucisymptomatic- which describes individuals who develop only mild disease.

He then argues that in NACs, the reason for their lack of progression to the disease state is a rapid NK cell response that clears the virus. This is possible, but he presents no evidence to support it. Current models attribute the lack of progression to (severe) disease in these patients to a rapid interferon response, and while interferon responses can promote NK cell activity to clear virally infected cells, the literature does not discuss a role for the cells, given that interferon can induce direct intracellular effectors that suppress viral replication and furthermore the presence of antibodies among asymptomatic individuals. Overexuberant NK cell responses are implicated in the development of severe COVID-19: afucosylated antibodies are extremely potent inducers of NK cell antibody-dependent cellular cytotoxicity (ADCC), and these are noted to be enriched in severe COVID-19. NK cell-mediated ADCC is extremely powerful for controlling viral infections, particularly before the adaptive immune system gets an opportunity to produce its effectors, and afucosylated antibodies are valuable players in that process, but the inflammation that results can be harmful to the health of the host if uncontrolled, such as if SARS-CoV-2 is given an opportunity to replicate extensively in a host, as might be the case in an individual whose immune system has not been primed against the virus with vaccination.
View fullsize
Screen+Shot+2021-03-15+at+3.40.23+PM.png
An extremely incorrect depiction of dendritic cell-NK cell interactions made by Geert Vanden Bossche.

He then commits an immunological faux pas so egregious that it genuinely shocks me where he shows a dendritic cell (DC) activating an NK cell via antigen presentation on an MHC class I protein. It is basically at this point that I cannot presume that this letter is written in good faith given Dr. Bossche’s background. This is absolutely not how NK cells work. For one thing, the presence of MHC class I protein on a cell indicates to an NK cell that no viral infection is present and functions as an inhibitory signal (indeed, it is a common feature that viruses suppress expression of MHC class I proteins on cells they infect because this prevents them from being recognized by cytotoxic T cells that can kill the cell they are relying on to replicate). For another, NK cells do not examine the contents of the antigen in the MHC binding cleft. They do not have T cell receptors (with the exception of iNKT cells) and therefore have no ability to do this. There ARE reciprocal NK cell-DC interactions where each supports the other (e.g. DCs may produce cytokines promoting the activation of NK cells and NK cell cytokines can promote DC maturation, and NK cells have been known to kill immature dendritic cells in the body) but the mechanism proposed here is overtly at odds with decades of immunology research.

Frankly, to focus on NK cells for a vaccine against an infectious disease is extremely unusual (they can be very important in cancer immunotherapy though). The goal of vaccines broadly is to elicit long-lived immunological memory against a particular infectious agent. NK cells are part of the innate immune system, and while they do exhibit epigenetic modifications after infection in what has been termed trained immunity, this is not the principle by which most vaccines work. Vaccines have to achieve robust activation of dendritic cells because they are key antigen presenting cells and they need to trigger generation of memory helper T cells, ideally T follicular helper cells, memory B cells, long-lived plasma cells, and potentially cytotoxic T cells (depending on the agent)- they act virtually independently of NK cells (though NK cells may play a supportive role through ADCC on challenge with the antigen).

It is very much downhill from here. While he does not use the term, the rest of the argument Bossche makes relies on a false assumption: currently available vaccines for COVID-19 are leaky vaccines. Correlates of vaccine-induced protection: methods and implications defines leaky vaccines as follows:
According to [the leaky vaccine model], the risk of infection/disease in all vaccinees is reduced (by VE %) compared to non-vaccinees, none of the vaccinees being fully protected.

The assumption that no vaccinee is totally or permanently protected implies one or both of the following:

i) No amount (titre) of the immune marker is totally protective or, if it is, no individual can maintain that titre for a long period (because of waning or transient immunosuppression);

ii) The degree of protection is a function of the level of the immune marker – the simplest explanation being that protection is a function of both the level of the immune marker and the challenge dose.​


In other words, leaky vaccines are vaccines which are not able to significantly affect transmission of the pathogen. The critical question here is firstly: are COVID-19 vaccines leaky vaccines?
  1. This study compared PCR positivity among asymptomatic individuals who had received an RNA vaccine to those who had not been vaccinated and found it was approximately 80% lower. This is a very strict bar and it likely underestimates the ability of the vaccines to reduce transmission, because PCR can detect as few as ~100 copies of viral RNA. SARS-CoV-2, being a coronavirus, likely requires several hundred viral copies to initiate productive infections from one person to the next. An asymptomatic individual who tests positive may not necessarily be contagious.
  2. Novavax’s vaccine demonstrated sterilizing immunity (the virus failed to even initiate infection) in nonhuman primate studies.
  3. ChAdOx-nCoV-2019 also showed significant reductions in PCR positivity among vaccinees compared with unvaccinated controls.
  4. The SIREN study showed that Pfizer’s vaccine prevents infection with B.1.1.7 variants.
  5. Pfizer’s vaccine was able to reduce viral load by a factor of about 4 among vaccinees compared with unvaccinated controls.
  6. The Johnson and Johnson/Janssen vaccine showed significant reductions in PCR positivity among vaccinees compared with controls.
And so on. In short, nothing about the COVID-19 vaccines suggests that they are leaky.

For a moment though, let’s entertain the notion that the vaccines are leaky. In general, you would have a hard time identifying any human vaccine that could be called leaky (though emerging findings regarding influenza vaccines give hints that there may be a leaky vaccine effect involved, given their excellent efficacy among children, who are critical vectors, I am not so convinced- though if we do grant that they are leaky, this only serves to undermine Bossche’s argument). The classic example of a leaky vaccine is actually the one for Marek’s disease, caused by a herpesvirus that infects chicken and causes lymphoma among other illnesses. It has been observed that over time Marek’s disease virus has become more virulent, and this has been attributed classically to a leaky vaccine effect. Still, as Osterrieder et al write (emphasis mine):
Box 2 | Marek’s disease vaccines — an open-ended success story Immunization against Marek’s disease (MD) was started in the late 1960s and first used avirulent Marek’s disease virus (MDV) or a virus very closely related to MDV, turkey herpesvirus 1 (HVT), which does not cause disease. Vaccination reduced the incidence of MD by 99% and presents a unique example of the successful application of a modified-live virus (MLV) vaccine against an extremely aggressive agent that can routinely causes >90% morbidity and mortality in susceptible, unvaccinated hosts7,116. Because MDV strains are constantly evolving towards greater virulence in the face of vaccination109 (BOX 1), combination vaccines consisting of HVT and gallid herpesvirus type 3 or an attenuated MDV strain, CVI988-Rispens, are currently used117–119.​


Clearly then, even a leaky vaccine can be used with great efficacy. What’s more is there is new research challenging the dogma of leaky vaccines selecting for greater virulence (emphasis mine):
We used controlled experiments involving natural virus transmission to reveal that vaccination with a leaky vaccine, which only marginally reduces transmission, can significantly reduce post-transmission disease development and mortality among unvaccinated contact individuals. Our analysis indicates that this effect is mediated by a reduction in exposure dose experienced by susceptible individuals when exposed to vaccinated shedders, leading to lower pathogen load and concomitant reduced symptoms in contact birds. The primary objectives of vaccination of livestock with leaky vaccines are to improve animal welfare and to reduce production losses caused by disease symptom development. Our results show that even partial vaccination against MD can substantially reduce disease symptoms and mortality in the whole flock, leading to universally positive impacts on animal welfare and productivity, and these conclusions may extend to leaky vaccines used in other systems.


Ending COVID-19 will require vaccination- this is not a matter of debate or discussion. Viruses evolve towards greater transmissibility, but they cannot evolve unless they have hosts. Fortunately, SARS-CoV-2 and other coronaviruses are unique in that they have a proofreading RNA-dependent RNA polymerase that slows mutation rates by a factor of about 20, which means they are slower to mutate, but this is irrelevant if they can infect well over 20 times more people than other RNA viruses. Vaccines clearly reduce viral load, prevent severe disease, and disrupt transmission, and they can thankfully be readily modified to address problematic variants as is done every season for influenza with great effect. They are the way out until someone proposes something better. Bossche doesn’t and his claims are baseless.
 

Amynamous

Active member
Hopefully all goes well then with the flu vaccine in combination with the boosters.Till now I haven't seen any goods from those vaccines.Youngsters dropping dead on the field or end up in the hospital with myocarditis.Since this year we see a huge excess mortality rate compared with last year when the pandemic started.Nursery homes outbreaks while they all are vaccinated and the government still telling to take the booster.Btw my niece took the booster, but got infected again and felt quite ill with a bloody headache for more then a week.
What I know now that those vaccines blocks your non-specific defense and the funny thing is that vitamin D increases your non-specific defense in other words make it stronger, that's why people with a high vitamin D level doesn't have much trouble with Covid, but that information is not given by the FDA & CDC.

The biggest difference between this year and last year is the delta variant, which has an extremely high transmissibility factor.
Prior to vaccine distribution, thanks to masking, social distancing, and other precautions, very few people had been infected with the virus.
With the rapid spread of the delta variant, with the average infected person spreading it to seven other people, most people have probably been infected.
Unril science shows us that the vaccines are actually to blame, the cardiovascular issues that people are seeing is most likely due to the virus..
 

mexcurandero420

See the world through a puff of smoke
Veteran
The biggest difference between this year and last year is the delta variant, which has an extremely high transmissibility factor.
Prior to vaccine distribution, thanks to masking, social distancing, and other precautions, very few people had been infected with the virus.
With the rapid spread of the delta variant, with the average infected person spreading it to seven other people, most people have probably been infected.
Unril science shows us that the vaccines are actually to blame, the cardiovascular issues that people are seeing is most likely due to the virus..

That makes no sense since the British variant was already more contagious than the previous variant we had and everybody nowadays need to show that they are negative before they get at the sporting centre.

Till now I just notice that Geert vanden Bossche is far more right than what an aspirant physician writes on his blog.My niece in here twenties also had her booster vaccine, sick as hell after got infected by friends.Heard yesterday some old people died, although they were fully vaccinated.
 

h.h.

Active member
Veteran
The biggest difference between this year and last year is the delta variant, which has an extremely high transmissibility factor.
Prior to vaccine distribution, thanks to masking, social distancing, and other precautions, very few people had been infected with the virus.
With the rapid spread of the delta variant, with the average infected person spreading it to seven other people, most people have probably been infected.
Unril science shows us that the vaccines are actually to blame, the cardiovascular issues that people are seeing is most likely due to the virus..

More science. Less populism.
 

Amynamous

Active member
That makes no sense since the British variant was already more contagious than the previous variant we had and everybody nowadays need to show that they are negative before they get at the sporting centre.

Till now I just notice that Geert vanden Bossche is far more right than what an aspirant physician writes on his blog.My niece in here twenties also had her booster vaccine, sick as hell after got infected by friends.Heard yesterday some old people died, although they were fully vaccinated.

I apologize if I wasn’t clear. The cardiovascular deaths can occur from the damage the virus causes to the vascular system, specifically inflammation and cellular debris. This can happen weeks or months AFTER a person was infected.

By the same token, If the vaccine causes inflammation or cellular debris, any resulting deaths would also take weeks or months to manifest. Until someone can actually PROVE the vaccines are causing cardiovascular deaths, it is much much more likely that it’s due to previous infection to the virus.

As for Geert, please read the rebuttal i posted.
 

Three Berries

Active member
Perhaps the other thing they had in common was a covid infection? The delta variant has a very high transmissibility factor and covid 19 can cause all of the same issues being attributed to the vaccines. Attributing these health issues to the vaccines without providing proof that the vaccine is actually the cause is irresponsible.

So you dismiss out of hand? That could be irresponsible! The people are dropping like flies. More injuries from this vaccine than all totaled for the entire time they have been keeping track with the VAREs data. And if you do have an adverse reaction they will not count it as being vaccine related unless it has been 14 days.
 

troutman

Seed Whore
If only vaccinated people can travel. Then it's them who are spreading it from country to country. :hide:

Snake oil vaccines can't fix things. Screw you Fauci and Bill Gates. :laughing:
 
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