You can decarb in an insta potDo you decarboxylate on a cookie sheet in the oven at low temperature before steeping in coconut oil in the jar, in a double boiler?
View attachment 19035418information-health-care-professionals-cannabis-cannabinoids-eng.pdf
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PDF LINK ABOVE 266pg ebook
TABLE OF CONTENTS
Page
List of figures and tables .................................................................................................................................................................. 1
List of abbreviations ........................................................................................................................................................................ 2
Authorship and acknowledgements ................................................................................................................................................. 7
Overview of summary statements .................................................................................................................................................. 11
1.0 The Endocannabinoid System ............................................................................................................................................... 18
1.1 Cannabis ............................................................................................................................................................................ 22
1.1.1 Chemistry and composition ....................................................................................................................................... 22
1.1.2 Other constituents ..................................................................................................................................................... 22
1.1.3 Stability and storage .................................................................................................................................................. 22
2.0 Clinical Pharmacology........................................................................................................................................................... 24
2.1 Pharmacodynamics ............................................................................................................................................................ 24
2.2 Pharmacokinetics ............................................................................................................................................................... 29
2.2.1 Absorption ................................................................................................................................................................ 30
2.2.1.1 Smoked cannabis ........................................................................................................................................... 30
2.2.1.2 Vapourized cannabis ..................................................................................................................................... 30
2.2.1.3 Oral ............................................................................................................................................................... 31
2.2.1.4 Oro-mucosal and intranasal ........................................................................................................................... 33
2.2.1.5 Rectal ............................................................................................................................................................ 33
2.2.1.6 Topical .......................................................................................................................................................... 33
2.2.2 Distribution ............................................................................................................................................................... 34
2.2.3 Metabolism ............................................................................................................................................................... 34
2.2.3.1 Inhalation ...................................................................................................................................................... 35
2.2.3.2 Oral ............................................................................................................................................................... 35
2.2.4 Excretion ................................................................................................................................................................... 36
2.3 Pharmacokinetic-pharmacodynamic relationships ............................................................................................................. 36
2.4 Tolerance, dependence, and withdrawal symptoms ........................................................................................................... 39
2.5 Special populations ............................................................................................................................................................ 43
3.0 Dosing ..................................................................................................................................................................................... 46
3.1 Smoking ............................................................................................................................................................................. 48
3.2 Oral .................................................................................................................................................................................... 51
3.3 Oro-mucosal ...................................................................................................................................................................... 52
3.4 Vapourization..................................................................................................................................................................... 52
4.0 Potential Therapeutic Uses .................................................................................................................................................... 54
4.1 Palliative care ..................................................................................................................................................................... 56
4.2 Quality of life ..................................................................................................................................................................... 57
4.3 Chemotherapy-induced nausea and vomiting .................................................................................................................... 59
4.4 Wasting syndrome (cachexia, e.g., from tissue injury by infection or tumour) and loss of appetite (anorexia) in
AIDS and cancer patients, and anorexia nervosa ..................................................................................................................... 62
4.4.1 To stimulate appetite and produce weight gain in AIDS patients ............................................................................. 62
4.4.2 To stimulate appetite and produce weight gain in cancer patients ............................................................................ 63
4.4.3 Anorexia nervosa ...................................................................................................................................................... 64
4.5 Multiple sclerosis, amyotrophic lateral sclerosis, spinal cord injury and disease ............................................................... 64
4.5.1 Multiple sclerosis ..................................................................................................................................................... 65
4.5.2 Amyotrophic lateral sclerosis .................................................................................................................................... 70
4.5.3 Spinal cord injury (or spinal cord disease) ................................................................................................................ 71
4.6 Epilepsy ............................................................................................................................................................................. 72
4.7 Pain .................................................................................................................................................................................... 78
4.7.1 Acute pain ................................................................................................................................................................. 80
4.7.1.1 Experimentally-induced acute pain ............................................................................................................... 81
4.7.1.2 Post-operative pain ........................................................................................................................................ 82
4.7.2 Chronic pain .............................................................................................................................................................. 82
vi
4.7.2.1 Experimentally-induced inflammatory and chronic neuropathic pain ........................................................... 82
4.7.2.2 Neuropathic pain and chronic non-cancer pain in humans ............................................................................ 82
4.7.2.3 Cancer pain ................................................................................................................................................... 91
4.7.2.4 “Opioid-sparing” effects and cannabinoid-opioid synergy ........................................................................... 93
4.7.2.5 Headache and migraine ................................................................................................................................ 98
4.8 Arthritides and musculoskeletal disorders ......................................................................................................................... 99
4.8.1 Osteoarthritis ............................................................................................................................................................. 99
4.8.2 Rheumatoid arthritis ................................................................................................................................................ 101
4.8.3 Fibromyalgia ........................................................................................................................................................... 102
4.8.4 Muscular pain ......................................................................................................................................................... 104
4.8.5 Osteoporosis ............................................................................................................................................................ 104
4.9 Other diseases and symptoms .......................................................................................................................................... 105
4.9.1 Movement disorders ............................................................................................................................................... 105
4.9.1.1 Dystonia ...................................................................................................................................................... 105
4.9.1.2 Huntington’s disease ................................................................................................................................... 107
4.9.1.3 Parkinson’s disease ..................................................................................................................................... 108
4.9.1.4 Tourette’s syndrome ................................................................................................................................... 109
4.9.1.5 Spinocerebellar ataxias .............................................................................................................................. 110
4.9.2 Glaucoma ............................................................................................................................................................... 110
4.9.3 Asthma ................................................................................................................................................................... 111
4.9.4 Hypertension .......................................................................................................................................................... 111
4.9.5 Stress and psychiatric disorders .............................................................................................................................. 111
4.9.5.1 Anxiety and depression .............................................................................................................................. 112
4.9.5.2 Sleep disorders ........................................................................................................................................... 114
4.9.5.3 Post-traumatic stress disorder ..................................................................................................................... 116
4.9.5.4 Alcohol and opioid withdrawal symptoms (drug withdrawal symptoms/drug substitution) ...................... 119
4.9.5.5 Schizophrenia and psychosis ...................................................................................................................... 121
4.9.6 Alzheimer’s disease and dementia .......................................................................................................................... 126
4.9.7 Inflammation .......................................................................................................................................................... 127
4.9.7.1 Inflammatory skin diseases (dermatitis, psoriasis, pruritus) ....................................................................... 128
4.9.8 Gastrointestinal system disorders (irritable bowel syndrome, inflammatory bowel disease,
hepatitis, pancreatitis, metabolic syndrome/obesity) .............................................................................................. 129
4.9.8.1 Irritable bowel syndrome ........................................................................................................................... 129
4.9.8.2 Inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) ............................................................ 131
4.9.8.3 Diseases of the liver (hepatitis, fibrosis, steatosis, ischemia-reperfusion injury, hepatic
encephalopathy) ..................................................................................................................................................... 135
4.9.8.4 Metabolic syndrome, obesity, diabetes ...................................................................................................... 137
4.9.8.5 Diseases of the pancreas (diabetes, pancreatitis) ........................................................................................ 141
4.9.9 Anti-neoplastic properties....................................................................................................................................... 142
4.9.10 Emerging potential therapeutic uses ..................................................................................................................... 146
5.0 Precautions ........................................................................................................................................................................... 147
6.0 Warnings .............................................................................................................................................................................. 148
6.1 Tolerance, dependence, and withdrawal symptoms ......................................................................................................... 149
6.2 Drug interactions ............................................................................................................................................................. 149
6.3 Drug screening tests ......................................................................................................................................................... 151
7.0 Adverse effects ..................................................................................................................................................................... 152
7.1 Carcinogenesis and mutagenesis ..................................................................................................................................... 153
7.2 Respiratory tract .............................................................................................................................................................. 154
7.3 Immune system ................................................................................................................................................................ 156
7.4 Reproductive and endocrine systems ............................................................................................................................... 158
7.5 Cardiovascular system ..................................................................................................................................................... 162
7.6 Gastrointestinal system and liver ..................................................................................................................................... 163
7.6.1 Hyperemesis ........................................................................................................................................................... 163
7.6.2 Liver ....................................................................................................................................................................... 164
7.7 Central nervous system .................................................................................................................................................... 164
Hmm, have to try that. I can see it working in a couple days. Will take awhile for it's completely gone.The salve works in like 2-3 days
I guess it depends on how bad it is. A friend used it and said it was better in 2 days to her surprise.Hmm, have to try that. I can see it working in a couple days. Will take awhile for it's completely gone.