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High Grade CANNABIS BIBLIOGRAPHY SORTED AND ALPHABETIZED BY SUBJECT

FellaAndrene

Well-known member
Question for @Sam_Skunkman - Have you (or anyone you know) ever bioassayed cannabisativine and/or the other lactam based alkaloids in Cannabis?

I was browsing through ElSohly's works, and it happened to me that cannabisativine's molecular structure could have some affinity to other receptors than the CB1 and CB2.

Running it through Swiss Target Prediction's database returned results for possible interaction with kappa opioid (salvinorin A target) and 5-HT2A (classical psychedelic) receptors.

I'm not that well versed in 5-HT2A pharmacophore, but the receptors certainly are very accepting towards a wide variety of different compounds (from piperazines to phenethylamines to lysergides to efavirenz).


Can you send me the reference of the El Sohly paper, as well as the paper the image is from?
-SamS
 

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chilliwilli

Waterboy
Veteran

Histochemical Evidence for Nitrogen-Transfer Endosymbiosis in Non-Photosynthetic Cells of Leaves and Inflorescence Bracts of Angiosperms​

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220352/

https://doi.org/10.3390/biology11060876

They found n fixing bacteria in different plant cells. N transfer was also observed and was most likely in glandular trichomes.
"Trichome chemistry is hypothesized to function to scavenge oxygen around bacteria to facilitate nitrogen fixation."

I have the paper, I will add to the BIB
-SamS
 
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acespicoli

Well-known member
My health is up & down now I am on oxygen all day as my blood oxygen levels are so low. My advice to all is DO NOT GET OLD. I will be 75 this month. I am a happy guy but my health sucks the last 2 years.
Im a July baby as well, it crossed my mind to check on you last couple days. Been awhile since you posted I know life can be tough at times... so I thought id check in and send get well wishes:huggg:
Hope this finds you doing well! :love:

Various Articles & a few below that are interesting, hope everyone enjoys them!
Best >>>

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Sci Adv. 2021 Jul; 7(29): eabg2286.
Published online 2021 Jul 16. doi: 10.1126/sciadv.abg2286
PMCID: PMC8284894
PMID: 34272249

Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa

(This one is interesting to me due to basal drug types)


screenshot-www_mdpi_com-2024_09_07-21_16_20.png

Plants 2023, 12(23), 3927; https://doi.org/10.3390/plants12233927

Naturally Occurring Triploidy in Cannabis​

(this article has some details and stats on natural well self explanatory... mutants)

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Front. Plant Sci., 24 June 2020
Sec. Plant Systematics and Evolution
Volume 11 - 2020 | https://doi.org/10.3389/fpls.2020.00718

Hermaphroditism in Marijuana (Cannabis sativa L.) Inflorescences – Impact on Floral Morphology, Seed Formation, Progeny Sex Ratios, and Genetic Variation​

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BMC Genomics. 2018; 19: 156.
Published online 2018 Feb 21. doi: 10.1186/s12864-018-4494-3
PMCID: PMC5822635
PMID: 29466945

Diversity and evolution of the repetitive genomic content in Cannabis sativa


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Genome Biol Evol. 2021 Aug; 13(8): evab130.
Published online 2021 Jun 8. doi: 10.1093/gbe/evab130
PMCID: PMC8521752
PMID: 34100927

Origin and Evolution of the Cannabinoid Oxidocyclase Gene Family​


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Plants 2019, 8(11), 496; https://doi.org/10.3390/plants8110496

Highly Predictive Genetic Markers Distinguish​

Drug-Type from Fiber-Type Cannabis sativa L​

screenshot-www_mdpi_com-2024_09_07-21_25_46.png


screenshot-kannapedia_net-2024_09_07-21_39_42.png

This chart represents the Illumina sequence coverage over the Bt/Bd allele. These are the three regions in the cannabis genome that impact THCA, CBDA, CBGA production. Coverage over the Active CBDAS gene is highly correlated with Type II and Type III plants as described by Etienne de Meijer. Coverage over the THCA gene is highly correlated with Type I and Type II plants but is anti-correlated with Type III plants. Type I plants require coverage over the inactive CBDA loci and no coverage over the Active CBDA gene. Lack of coverage over the Active CBDA and Active THCA allele are presumed to be Type IV plants (CBGA dominant). While deletions of entire THCAS and CBDAS genes are the most common Bt:Bd alleles observed, it is possible to have plants with these genes where functional expression of the enzyme is disrupted by deactivating point mutations (Kojoma et al. 2006).

Some people mentioned you were working on collecting white papers, some of my favorite here.
Hope everyone finds them useful
 
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