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The Original O'l Farts Club.
- Thread starter Putembk
- Start date
Who could sleep with all that noise ..Im up FFS!
* Hmmm - getting more serious today - here is something that I have been reading about lately - and I hope that you all can see the importance of it -
Autophagy - the Immense Benefits of Fasting
Daniel John | SQ Online (2021-2022)
Archive
·October 19, 2021·8 min read
By now it's likely you’ve either tried or at least heard of one of the many dieting strategies that are out there. Fundamentally, dieting is understood in terms of caloric input and output–maintaining a caloric deficit between the energy our bodies use and our daily food intake.
In recent years, we’ve come to understand that effective dieting isn’t just about how much you eat but more so what you eat. One popular diet limits the body’s intake of carbohydrates to initiate a process called ketosis, which burns fat at a faster rate–but more on that later. The average adult on a caloric-cutting diet needs to burn 500 more calories than they consume per day to lose four pounds of fat in a month; however, with a regimented ketogenic diet, the average adult can expect to lose ten pounds every month by carefully watching the types of foods they consume.
When I asked my doctor about dieting, he suggested a current approach to losing weight called intermittent fasting. This process consists of fasting at different time intervals during the day. As it turns out, when you eat also plays a significant role in weight loss and in improving overall health. As such, intermittent fasting provides several benefits over food-selective diets, such as the ketogenic diet. For starters, embarking on a ketogenic diet requires drastic lifestyle change, as it can be difficult to alter eating habits you’ve had your whole life. Additionally, the ketogenic diet doesn’t have the same effect on everyone; although it is highly beneficial for some–this diet has even slowed down the spread of diabetes–many have reported negative side-effects such as headaches, fatigue, and poor sleep. On the other hand, although intermittent fasting can be challenging, doctors have been recommending the practice because it allows patients to reap immense health benefits without completely overhauling their eating preferences and with minimal side-effects.
Interestingly enough, if I were to go back in time to 460 B.C. and ask a Greek doctor for dieting advice, they too would argue in favor of intermittent fasting. As Hippocrates once said:
“The natural healing force within each one of us is the greatest force in getting well. Our food should be our medicine. Our medicine should be our food. But to eat when you are sick is to feed your sickness.”
The ancient Greeks believed nature was the most powerful healing force in the cosmos. To them, the human body was sacred and divine, innately possessing supernatural methods of healing. Hippocrates famously referred to fasting as the “physician within;” however, as the Greeks did with many ideas, they left us more theories than explanations for this phenomenon.
Thus, the mystery of the physician within was not understood until the late 1980s, when a Japanese researcher observed how vacuoles, which are large, sac-like structures that store cellular waste, responded to starvation in mutated yeast cells. Under his electron microscope, the young researcher Yoshinori Ohsumi observed the process of autophagy, or the cell’s method of consuming its own proteins to meet energy requirements during starvation.
Cellular Autophagy visualized (Source)
Within thirty minutes of starving the yeast cells, Ohsumi observed the formation of small spherical structures that degraded various intracellular components such as harmful proteins, organelles, and enzymes in response to starvation-induced stress. He named these structures autophagosomes.
Since his discovery in 1988, Ohsumi has worked to elucidate the mechanism of the physician within.
Uncovering the link between fasting and health culminated in him winning the 2016 Nobel Prize in Physiology or Medicine for characterizing the cellular pathways of autophagy. Ohsumi discovered that fasting induces cells to switch on autophagy-related mechanisms, roping in a variety of cellular components to recycle for energy and other cellular processes.
Autophagy is a non-selective process that is regularly used to recycle misfolded proteins, damaged organelles, dangerous bacteria, and other abnormal components during cellular checkpoints. Autophagy is vital for cell homeostasis, and its absence leads to abnormal cell growth, shortened cell survival, and increased cell susceptibility to disease. As we age, the rate of autophagy in our cells vastly diminishes, leading to unchecked cell cycle checkpoints and therefore increasing the chances of cells spiraling into disease. Thus, for older individuals, fasting is a great way to revive autophagy levels and recycle cellular components that may otherwise cause disease.
Recent research has also revealed that autophagy selectively removes specific proteins that are known to moderate a variety of diseases, such as Parkinson’s disease. In Parkinson’s, autophagy degrades ð°-synuclein and PINK1-PARKIN, both of which are known to promote a diseased state. Similarly, autophagy removes proteins and oncoproteins that cause other diseases such as Alzheimer’s and cancer. Due to autophagy’s role in regulating tumor suppressive genes and oncoproteins in many cancers, researchers are studying autophagy treatment as a potential therapy for cancer patients.
On top of being used for temporary treatment, fasting can be a game-changer while we work to find the cure for illnesses like cancer, Parkinson’s disease, and Alzheimer’s disease. While in many cases these diseases can only be slowed down rather than stopped, delaying the onset of the disease could help protect quality of life.
What is the best way to benefit from autophagy? Research has shown that autophagy kicks in after 12-16 hours of continuous fasting. There are many different methods to reach 12-16 hours of fasting, and intermittent fasters choose a method depending upon their eating preferences.
The 16/8 method involves fasting everyday for 16 hours and eating a restricted diet during the remaining 8 hours of the day. If you’re a breakfast-skipper, this method is ideal, as it can be achieved by simply skipping dinner and breakfast. While 16/8 may be the easiest fasting method, it comes with its own drawbacks. Inducing autophagy everyday may not be good for the body’s metabolism. Furthermore, 16 hours of fasting is just enough to initiate autophagy in many individuals. Therefore, a longer fasting period may be necessary to reap substantial benefits.
The 5:2 diet is an intermittent fasting strategy more appropriate to beginner fasters, but has been shown to be an effective weight-loss strategy while maintaining lean muscle mass. In this dieting strategy, one may eat normally during five days of the week and restrict daily caloric intake to 500 calories during the remaining two days of the week. This provides cells with a minimal intake of energy, forcing them to supply the rest through autophagy.
Before attempting more intense methods of fasting, it is important to consult your doctor and become comfortable with fasting on regular, smaller intervals. Once your body is used to fasting, full 24-hour fasts a couple times a week may be used to “cleanse” the body, which seems to have the most anti-aging and autophagy-inducing effects out of the different diet strategies, according to recent studies.
While interventive treatment of many diseases still remains limited, our bodies provide an immensely beneficial, innate way of healing through autophagy. Autophagy is a human mechanism evolved for us to take advantage of the physician within.
https://sqonline.ucsd.edu/2021/10/autophagy-the-immense-benefits-of-fasting/
serious is a good thing in general and taking care of our health specifically is a good thing..
we learned to fast as kids , not by choice , figure it out , 10 mouths to feed on a gandydancers income and sometimes the kitchen cabinets were bare
then I joined a cult,who required fasting at least 2 days a week , mandatory
i did a 14 day fast once and several 3 day fasts
still fast today , only in shorter spurts , like 12-16 hours
also since my gf went carnivore , which helped her immensely , she battles colitis , Chrons , IBS , stomach digestive issues and the carnivore diet works for her
me not so much although I am thoroughly enjoying a nice t-bone or porterhouse steak once or twice a week….
and hamburgers..gawd I love me a good burger I ain’t gonna lie
so yeah , no food after 7 pm and sometimes no food until about 10 am
but plenty of coffee anytime , any day
I saw a YT video of two guys hunting and a mountain lion gave a howl.I fast regularly its good for the body and soul.
Drink lots of water preferably from a natural source and unfiltered.
Had a mountain lion screaming out back last night which really got the dogs excited.
It was enough for me to shut down the computer and gets me a samich to calm my self down,
How does one let their dogs out at night with them around?
With that said ,I have seen YT videos of looks like India where they keep their dogs outside on the front step and leopards snatch them all the time.
Morning OFC. HAPPY SUNDAY. Gonna be a nice day here.
I just checked in on the goings on in the basement an all is well! Little maintenance but nothing big happening down there today.
I see a walk in my near future today. Lake is peaceful this time of year. No boats or people out for a relaxing day by the water. Just hard core bikers and power walkers.
Local football team got their ass kicked last night virtually ending all playoff aspersions.... always next year
I just checked in on the goings on in the basement an all is well! Little maintenance but nothing big happening down there today.
I see a walk in my near future today. Lake is peaceful this time of year. No boats or people out for a relaxing day by the water. Just hard core bikers and power walkers.
Local football team got their ass kicked last night virtually ending all playoff aspersions.... always next year
for what?
Not for cannabis extraction, as that would be illegal here locally, but opportunities arise for experimentation in local licensed labs, and it is a robust pump that makes quick work of the slow part of the process.
At the time it was like comparing the 45 cu/in Harley Twin versus the 49CC displacement motor bikes in its application and price range.
I actually bought it in a large part to help a defunct extraction lab owner whose wife has cancer, and needed money more than they needed the pump. That as well as to have an example of that creations in my collection of treasures.
Sadly, not the original SN000001 test sled, which Joe and I tested to destruction, but a good example of the design. I still have the original Terpenator Mk III SN0000001 and Lil Terp SN000001, as well as the Grinning Reaper SN000001 in my collection, which is why it takes one two car garage and a single to enshrine all my treasures.
Given how fast the cannabis industry has expanded and how time flies, the last WolfWurx Mk IVC Terpenator SN000013 is now in a glass case in Las Vegas showcased as a museum piece.
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I’m sure your two car garage plus one would be like a museum trip for me
Two and a half years ago - during covid lockdown - I got on the scales and was shocked to find out that I was 265lbs heavy! - I was a fat lump and I felt terrible - my old back sports injury was so bad that I couldn't walk more than 100 yards without screaming in pain - my heart was so encumbered that big palpitations kept me up worrying at night - my blood pressure was extremely high - I was even starting to find it difficult to clean myself properly after a session on the can ! (Shock-Horror!) - and I didn't smell so good either (yuck) - so I had to embark on a life changing diet and fitness regime - starting slowly/gently I joined a gym with a pool - and commenced working out just in water initially - back in the 90's I was a qualified aerobics (aqua/high and low impact and boxercise) teacher - plus had a diploma in personal training - so knew what I had to do -
The diet I chose was The Keto Diet - with 18/6 daily intermittent fasting - eating only within a 6 hour window every day - after less than one year I had managed to get back to the weight I was when I was 26 years old (210lbs) - and was 62 years old at the time -
The biometrics machine at the gym told me that I had the body of a 47 year old man!
Since then I have managed to keep that 210lb/95 kilo weight and firm it all up considerably - with regular daily weight training sessions - one hour lifting - one hour in the pool - and 5 miles fast walking daily (for cardio) - but soon realised that I was overtraining - so have since changed things and only go to the gym every other day - but still walk that distance daily -
When I started my waist was 50 inches around - but now it's only 33 and a half inches - luckily my skin is more elastic that many others so I don't have hardly any excess anywhere - my strength and muscle mass has returned to what it was when I won the Mr Hong Kong Heavyweight Bodybuilding title I'm 1986 (amateur without steroids) - and generally I feel great most of the time - and am now stronger and fitter than most 18 year olds - but about a year ago found out that I had blown the seal on the Mitral valve in my heart
- and this needs fixing (waiting for surgery) - but doesn't stop me training - I just have to be sensible about it - so don't generally let my heart beat over around 130bpm - and have a resting heart rate of 45bpm -
-My blood pressure now is usually around 120-130 systolic - and 70-80 diastolic - with a little help from 5mg's of Amlodipine daily - far below what it was when I started - also my testosterone is up due to training - my past waning libido has been invigorated by all of this - so Mrs Nirvana - who is 23 years younger than me - is more than happy about it all -
Before I had lost all confidence in my own mobility - and lived in such pain - but now - I feel so much younger and stronger and confident again - with very minimal pain in my back - that I hardly notice it -
The diet I chose was The Keto Diet - with 18/6 daily intermittent fasting - eating only within a 6 hour window every day - after less than one year I had managed to get back to the weight I was when I was 26 years old (210lbs) - and was 62 years old at the time -
The biometrics machine at the gym told me that I had the body of a 47 year old man!
Since then I have managed to keep that 210lb/95 kilo weight and firm it all up considerably - with regular daily weight training sessions - one hour lifting - one hour in the pool - and 5 miles fast walking daily (for cardio) - but soon realised that I was overtraining - so have since changed things and only go to the gym every other day - but still walk that distance daily -
When I started my waist was 50 inches around - but now it's only 33 and a half inches - luckily my skin is more elastic that many others so I don't have hardly any excess anywhere - my strength and muscle mass has returned to what it was when I won the Mr Hong Kong Heavyweight Bodybuilding title I'm 1986 (amateur without steroids) - and generally I feel great most of the time - and am now stronger and fitter than most 18 year olds - but about a year ago found out that I had blown the seal on the Mitral valve in my heart
- and this needs fixing (waiting for surgery) - but doesn't stop me training - I just have to be sensible about it - so don't generally let my heart beat over around 130bpm - and have a resting heart rate of 45bpm - -My blood pressure now is usually around 120-130 systolic - and 70-80 diastolic - with a little help from 5mg's of Amlodipine daily - far below what it was when I started - also my testosterone is up due to training - my past waning libido has been invigorated by all of this - so Mrs Nirvana - who is 23 years younger than me - is more than happy about it all -
Before I had lost all confidence in my own mobility - and lived in such pain - but now - I feel so much younger and stronger and confident again - with very minimal pain in my back - that I hardly notice it -
And of course, you are invited to visit and tour, but it might be more like a tour of a hazardous storage site, while a trip through time and my pocketbook for me.I’m sure your two car garage plus one would be like a museum trip for me
Sun&Soil
Well-known member
Yep, I will be getting off the couch now. Thanks for the motivation!Two and a half years ago - during covid lockdown - I got on the scales and was shocked to find out that I was 265lbs heavy! - I was a fat lump and I felt terrible - my old back sports injury was so bad that I couldn't walk more than 100 yards without screaming in pain - my heart was so encumbered that big palpitations kept me up worrying at night - my blood pressure was extremely high - I was even starting to find it difficult to clean myself properly after a session on the can ! (Shock-Horror!) - and I didn't smell so good either (yuck) - so I had to embark on a life changing diet and fitness regime - starting slowly/gently I joined a gym with a pool - and commenced working out just in water initially - back in the 90's I was a qualified aerobics (aqua/high and low impact and boxercise) teacher - plus had a diploma in personal training - so knew what I had to do -
The diet I chose was The Keto Diet - with 18/6 daily intermittent fasting - eating only within a 6 hour window every day - after less than one year I had managed to get back to the weight I was when I was 26 years old (210lbs) - and was 62 years old at the time -
The biometrics machine at the gym told me that I had the body of a 47 year old man!
Since then I have managed to keep that 210lb/95 kilo weight and firm it all up considerably - with regular daily weight training sessions - one hour lifting - one hour in the pool - and 5 miles fast walking daily (for cardio) - but soon realised that I was overtraining - so have since changed things and only go to the gym every other day - but still walk that distance daily -
When I started my waist was 50 inches around - but now it's only 33 and a half inches - luckily my skin is more elastic that many others so I don't have hardly any excess anywhere - my strength and muscle mass has returned to what it was when I won the Mr Hong Kong Heavyweight Bodybuilding title I'm 1986 (amateur without steroids) - and generally I feel great most of the time - and am now stronger and fitter than most 18 year olds - but about a year ago found out that I had blown the seal on the Mitral valve in my heart
-My blood pressure now is usually around 120-130 systolic - and 70-80 diastolic - with a little help from 5mg's of Amlodipine daily - far below what it was when I started - also my testosterone is up due to training - my past waning libido has been invigorated by all of this - so Mrs Nirvana - who is 23 years younger than me - is more than happy about it all -
Before I had lost all confidence in my own mobility - and lived in such pain - but now - I feel so much younger and stronger and confident again - with very minimal pain in my back - that I hardly notice it -
I still try but I am 10 years older than you GN. I remember at 66 I thought I was bulletproof. No meds an felt great....now at 73 I still try but arthritis, hearing and now eyes are slowly taking over.Two and a half years ago - during covid lockdown - I got on the scales and was shocked to find out that I was 265lbs heavy! - I was a fat lump and I felt terrible - my old back sports injury was so bad that I couldn't walk more than 100 yards without screaming in pain - my heart was so encumbered that big palpitations kept me up worrying at night - my blood pressure was extremely high - I was even starting to find it difficult to clean myself properly after a session on the can ! (Shock-Horror!) - and I didn't smell so good either (yuck) - so I had to embark on a life changing diet and fitness regime - starting slowly/gently I joined a gym with a pool - and commenced working out just in water initially - back in the 90's I was a qualified aerobics (aqua/high and low impact and boxercise) teacher - plus had a diploma in personal training - so knew what I had to do -
The diet I chose was The Keto Diet - with 18/6 daily intermittent fasting - eating only within a 6 hour window every day - after less than one year I had managed to get back to the weight I was when I was 26 years old (210lbs) - and was 62 years old at the time -
The biometrics machine at the gym told me that I had the body of a 47 year old man!
Since then I have managed to keep that 210lb/95 kilo weight and firm it all up considerably - with regular daily weight training sessions - one hour lifting - one hour in the pool - and 5 miles fast walking daily (for cardio) - but soon realised that I was overtraining - so have since changed things and only go to the gym every other day - but still walk that distance daily -
When I started my waist was 50 inches around - but now it's only 33 and a half inches - luckily my skin is more elastic that many others so I don't have hardly any excess anywhere - my strength and muscle mass has returned to what it was when I won the Mr Hong Kong Heavyweight Bodybuilding title I'm 1986 (amateur without steroids) - and generally I feel great most of the time - and am now stronger and fitter than most 18 year olds - but about a year ago found out that I had blown the seal on the Mitral valve in my heart
-My blood pressure now is usually around 120-130 systolic - and 70-80 diastolic - with a little help from 5mg's of Amlodipine daily - far below what it was when I started - also my testosterone is up due to training - my past waning libido has been invigorated by all of this - so Mrs Nirvana - who is 23 years younger than me - is more than happy about it all -
Before I had lost all confidence in my own mobility - and lived in such pain - but now - I feel so much younger and stronger and confident again - with very minimal pain in my back - that I hardly notice it -
Not giving up but every year age is not my friend.
I've been trying to lose 25 lbs unsuccessfully for the last year, so will check out the Keto diet.Two and a half years ago - during covid lockdown - I got on the scales and was shocked to find out that I was 265lbs heavy! - I was a fat lump and I felt terrible - my old back sports injury was so bad that I couldn't walk more than 100 yards without screaming in pain - my heart was so encumbered that big palpitations kept me up worrying at night - my blood pressure was extremely high - I was even starting to find it difficult to clean myself properly after a session on the can ! (Shock-Horror!) - and I didn't smell so good either (yuck) - so I had to embark on a life changing diet and fitness regime - starting slowly/gently I joined a gym with a pool - and commenced working out just in water initially - back in the 90's I was a qualified aerobics (aqua/high and low impact and boxercise) teacher - plus had a diploma in personal training - so knew what I had to do -
The diet I chose was The Keto Diet - with 18/6 daily intermittent fasting - eating only within a 6 hour window every day - after less than one year I had managed to get back to the weight I was when I was 26 years old (210lbs) - and was 62 years old at the time -
The biometrics machine at the gym told me that I had the body of a 47 year old man!
Since then I have managed to keep that 210lb/95 kilo weight and firm it all up considerably - with regular daily weight training sessions - one hour lifting - one hour in the pool - and 5 miles fast walking daily (for cardio) - but soon realised that I was overtraining - so have since changed things and only go to the gym every other day - but still walk that distance daily -
When I started my waist was 50 inches around - but now it's only 33 and a half inches - luckily my skin is more elastic that many others so I don't have hardly any excess anywhere - my strength and muscle mass has returned to what it was when I won the Mr Hong Kong Heavyweight Bodybuilding title I'm 1986 (amateur without steroids) - and generally I feel great most of the time - and am now stronger and fitter than most 18 year olds - but about a year ago found out that I had blown the seal on the Mitral valve in my heart
-My blood pressure now is usually around 120-130 systolic - and 70-80 diastolic - with a little help from 5mg's of Amlodipine daily - far below what it was when I started - also my testosterone is up due to training - my past waning libido has been invigorated by all of this - so Mrs Nirvana - who is 23 years younger than me - is more than happy about it all -
Before I had lost all confidence in my own mobility - and lived in such pain - but now - I feel so much younger and stronger and confident again - with very minimal pain in my back - that I hardly notice it -
Good man! - initially the quest ahead of you may seem insurmountable - but once you embark upon it - with the required discipline needed - you will see results - and this will help you to 'sally-forth' to a healthier/lighter and stronger future -
Lots of Power boats and only 2 sail.
also check out the carnivore diet….i am basically a keto carnivore who cheats
190 lbs 33 waist 6’1”
