Ice chilling in the EZ clone (Ohaze & NH x C5 M)
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The Haze discussion thread
- Thread starter @hempy
- Start date
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Thanks for sharing she looks delicious, love that dark green Golden brownish look
How she’s smoke ?
1luvbigherb
Nexus7
Well-known member
Still testing but early reports are promising.
Positive, up, clean and clear with no comedown. All in the temples. Long lasting too. Great daytime smoke!
Can leave you stunned in a daze but only if let it. But never with any comedown.
Can't wait to try it after a proper cure!
Last edited:
funkyhorse
Well-known member
Nexus description can be applied to the early samples of MMohz I am vaping
Hempy, you asked me about Kerala
The smoke is a few levels below MMohz but if you go to Goa and get served this stuff, you would remain a few days without complaining much as long as you are sourcing charas too
What I do see is an interesting difference between the outdoor plant grown from seed or cut and the indoor grown one
They dont make the same kind of buds, I wonder if the high is different too. I have experienced hybrids with a better high indoors than outdoors
Kerala indoors on 11/13 day 63
Have a nice week
Hempy, you asked me about Kerala
The smoke is a few levels below MMohz but if you go to Goa and get served this stuff, you would remain a few days without complaining much as long as you are sourcing charas too
What I do see is an interesting difference between the outdoor plant grown from seed or cut and the indoor grown one
They dont make the same kind of buds, I wonder if the high is different too. I have experienced hybrids with a better high indoors than outdoors
Kerala indoors on 11/13 day 63
Have a nice week
sounds interesting a diffrent version of mango haze did you keep the queenie cut ?
Grab you one of these and run it 1min on/5 off no more heat issues. I finally did and no longer have issues with the rez temp.
$26
https://www.amazon.com/BN-LINK-Peri...ocphy=9057205&hvtargid=pla-370354391477&psc=1
@hempy
The Haze Whisperer
Hi Funkyhorse i ran an experiment years ago on out doors vs indoors using i think 9 clones what i saw was taste and look from indoors to out doors were different but the potency /affect or duration of high did not change.
@hempy
The Haze Whisperer
Out of all the Mango Haze test seed i selected Queeny and a plant i call OTHEER and a male i called HAZEY.
I use the male to make F2s and kept the 2 fems for almost 10 years until i lost them because of a mites that came from a nussary bought cucumber plant short version.
JohnnyChicago
Well-known member
It's my pure SeedsmanOH x GolliOH, that Madmac got both from us to share with the community.
Regarding the "SamS OH" discussion. I do believe GolliOH might be the oldest of the SamS OH's that are around, as it got shared by SamS more than 20 years ago.
Just an opinion.
Nexus7
Well-known member
I'm the same way just not as high on Sativas. The hazes/Sativas on the pure side do not affect me much. I can smoke 10x more of those and still not feel much. These genetics will make hybrids better by adding terps or making those terps stronger that we love so much. Lots of us do not experience Haze/sat the same as others, that's OK..
Psychedelic Science ReviewSearch for:
CannabisIs Cannabis a Psychedelic Drug?
Yes, and it may work via 5-HT2A as well as the cannabinoid receptors.
October 31, 2019 - By Barbara E. Bauer, MS
Image from Shutterstock.
Cannabis is a genus of plants (aka marijuana, hemp), not a drug, although the term is often used interchangeably. Recently, there has been an explosion in the terminology, abbreviations, and chemical names associated with cannabis. This can be confusing when trying to understand cannabis and how it works. To begin, here are a few terms to know and their definitions:
Figure 1: The chemical structures of the cannabinoids THC, CBN, and CBD.
What is a Psychedelic Drug?
The term psychedelic was created by English psychologist and researcher Humphry Osmond. He derived it from the Greek words for mind or soul (psyche) and show (deloun) to describe the effect LSD had on the mind. Osmond first used the word in a presentation he gave at the New York Academy of Sciences in 1957.[SUP]1[/SUP]
Basically, there are two ways to figure out if a drug is psychedelic. The first is based on its receptor binding. The second is to compare the effects of the drug to what are considered psychedelic effects. If a compound passes the test for either or both, then it is psychedelic.
In terms of receptors, scientists classify a drug as psychedelic if it binds to serotonin 5-HT[SUB]2A[/SUB] receptors (5-HT[SUB]2A[/SUB]R) as an agonist or partial agonist[SUP]2–4[/SUP] (these are typically tryptamine compounds which are chemically similar to serotonin). The hallucinogenic effects of agonist binding are mediated via the 5-HT[SUB]2A[/SUB]R receptor-coupled signaling pathway.[SUP]2,3[/SUP] This pathway is not entirely understood, but researchers theorize that it involves activation of the enzyme phospholipase C leading to the formation of inositol phosphates and diglycerol (signaling molecules) which causes the release of calcium ions from the endoplasmic reticulum in the cell. The possibility also exists that other serotonin receptors may be involved in the overall psychedelic experience of a user.
Interestingly, the effects of psychedelic drugs are highly variable and may not be dose-dependent.[SUP]4[/SUP] With LSD, for example, low doses (about <100 µg) may cause some distortion of cognitive and sensory processes with the person remaining aware that the drug is causing the effects. Higher doses may “…transport the user to an alternate reality, where they lose contact with their everyday environment.” These are the transcendent or mystical experiences that represent states of consciousness that are profoundly altered from reality.
From a medical standpoint, it is now understood by researchers that having a mystical experience results in a dramatic improvement for patients using psychedelic-assisted therapy.[SUP]5–8[/SUP] However, the mystical phenomenon can occur when using almost any dose of a psychedelic as long as the set and setting have been optimized to promote an altered state of consciousness.[SUP]4[/SUP]
THC and other compounds in cannabis that have been tested elicit their effects by binding as agonists or partial agonists on the cannabinoid receptors CB[SUB]1[/SUB] and CB[SUB]2[/SUB]. Like the serotonin receptors, cannabinoid receptors belong to the G protein-coupled receptor (GPCR) family.
When it comes to 5-HT[SUB]2A[/SUB]R, current research indicates THC binding may have a role in the development of schizophrenia in young adults with long-term cannabis use.[SUP]9[/SUP] This study found that in young mice, long-term exposure to THC “…induced a pro-hallucinogenic molecular conformation of the 5-HT[SUB]2A[/SUB]R.” The researchers also observed “…exacerbated schizophrenia-like responses…” in the mice. These observations of the modification of 5-HT[SUB]2A[/SUB]R by THC is not only a ground-breaking finding but it also adds to the evidence of cannabis being a psychedelic drug based on receptor binding.
Comparing the Effects of Cannabis and Psychedelics
Although the chemistry of the classic psychedelics and the compounds in cannabis are very different from each other, they have remarkably similar effects in many people.
In 1964, the iconic psychedelic researcher and advocate Timothy Leary, along with colleagues Ralph Metzner and Richard Alpert (aka Ram Dass), developed a scale for measuring the intensity of a psychedelic experience.[SUP]10[/SUP] Based on its effects, they included marijuana as a psychedelic in their analysis. The researchers said the effects of moderate to high doses of cannabis included synesthesia, enhanced perception of music, visual effects (including patterns) with the eyes closed, the emergence of unconscious emotions, and unrestrained creative and abstract thought patterns. Many of these effects are common for users of psychedelics taken at low to moderate doses.
Taking higher doses of psychedelics results in out-of-body and mystical experiences for some users along with ego dissolution. Some experts think that cannabis can cause ego dissolution, too. Stephen Gray, editor, and contributor to the book “Cannabis and Spirituality: An Explorer’s Guide to an Ancient Plant Spirit Ally” told PotGuide in an interview that “Cannabis is both gentle and intense. If you take a large enough dosage to actually do that kind of work [achieve ego dissolution], it can be quite powerful.” Gray implies that the ability of cannabis to do this may have a lot to with a person’s intent (part of the set and setting) when taking it.
Summary
Experts consider cannabis a psychedelic drug in terms of its effects and possibly its binding to 5-HT[SUB]2A[/SUB]R. New research is indicating that the psychedelic serotonin 5-HT[SUB]2A[/SUB] receptor may play a role in the adverse effects of chronic cannabis use in adolescents. Although the psychedelic experience can be highly variable, cannabis and psychedelics, in general, have many effects in common.
Overall, it’s important to remember that both cannabis and naturally occurring psychedelics like psilocybin mushrooms (aka magic mushrooms) contain a cocktail of compounds, many of which have not been characterized. Further, understanding the entourage effect in cannabis and magic mushrooms may reveal other similarities in their receptor affinities and effects.
Comments
CannabisIs Cannabis a Psychedelic Drug?
Yes, and it may work via 5-HT2A as well as the cannabinoid receptors.
October 31, 2019 - By Barbara E. Bauer, MS
Image from Shutterstock.Cannabis is a genus of plants (aka marijuana, hemp), not a drug, although the term is often used interchangeably. Recently, there has been an explosion in the terminology, abbreviations, and chemical names associated with cannabis. This can be confusing when trying to understand cannabis and how it works. To begin, here are a few terms to know and their definitions:
- Cannabis – Also called marijuana or hemp. This is a genus of flowering plants that are indigenous to Central Asia and the Indian Subcontinent. Two of the most well-known species grown for their psychoactive effects are Cannabis sativa and Cannabis indica. To make hemp, C. sativa plants are grown to produce different strains that contain much lower levels of psychoactive chemicals. The psychoactive compounds in cannabis are most abundant in the buds (flowers) of the plant.
- Cannabinoids (Figure 1) – This is a class of over 100 chemical compounds found in cannabis plants. Here are three of the most well-known:
- Cannabinol (CBN) – A non-psychoactive compound that is not synthesized by the plant but is an oxidation breakdown product of most abundant cannabinoid, THC (see below). CBN does have some entourage effect when combined with THC, resulting in greater sedation effects. CBN has not been thoroughly studied but may it have antibiotic and anti-inflammatory properties.
- Cannabidiol (CBD) – Another non-psychoactive compound in cannabis. CBD by itself is believed to have many health benefits and can be found in many over the counter products. CBD is also the active component in the recently FDA-approved epilepsy drug Epidiolex.
- Tetrahydrocannabinol (THC) – This is the most abundant compound in cannabis and it is responsible for many of its euphoric and psychoactive effects.
Figure 1: The chemical structures of the cannabinoids THC, CBN, and CBD.
What is a Psychedelic Drug?
The term psychedelic was created by English psychologist and researcher Humphry Osmond. He derived it from the Greek words for mind or soul (psyche) and show (deloun) to describe the effect LSD had on the mind. Osmond first used the word in a presentation he gave at the New York Academy of Sciences in 1957.[SUP]1[/SUP]
Basically, there are two ways to figure out if a drug is psychedelic. The first is based on its receptor binding. The second is to compare the effects of the drug to what are considered psychedelic effects. If a compound passes the test for either or both, then it is psychedelic.
In terms of receptors, scientists classify a drug as psychedelic if it binds to serotonin 5-HT[SUB]2A[/SUB] receptors (5-HT[SUB]2A[/SUB]R) as an agonist or partial agonist[SUP]2–4[/SUP] (these are typically tryptamine compounds which are chemically similar to serotonin). The hallucinogenic effects of agonist binding are mediated via the 5-HT[SUB]2A[/SUB]R receptor-coupled signaling pathway.[SUP]2,3[/SUP] This pathway is not entirely understood, but researchers theorize that it involves activation of the enzyme phospholipase C leading to the formation of inositol phosphates and diglycerol (signaling molecules) which causes the release of calcium ions from the endoplasmic reticulum in the cell. The possibility also exists that other serotonin receptors may be involved in the overall psychedelic experience of a user.
Interestingly, the effects of psychedelic drugs are highly variable and may not be dose-dependent.[SUP]4[/SUP] With LSD, for example, low doses (about <100 µg) may cause some distortion of cognitive and sensory processes with the person remaining aware that the drug is causing the effects. Higher doses may “…transport the user to an alternate reality, where they lose contact with their everyday environment.” These are the transcendent or mystical experiences that represent states of consciousness that are profoundly altered from reality.
From a medical standpoint, it is now understood by researchers that having a mystical experience results in a dramatic improvement for patients using psychedelic-assisted therapy.[SUP]5–8[/SUP] However, the mystical phenomenon can occur when using almost any dose of a psychedelic as long as the set and setting have been optimized to promote an altered state of consciousness.[SUP]4[/SUP]
THC and other compounds in cannabis that have been tested elicit their effects by binding as agonists or partial agonists on the cannabinoid receptors CB[SUB]1[/SUB] and CB[SUB]2[/SUB]. Like the serotonin receptors, cannabinoid receptors belong to the G protein-coupled receptor (GPCR) family.
When it comes to 5-HT[SUB]2A[/SUB]R, current research indicates THC binding may have a role in the development of schizophrenia in young adults with long-term cannabis use.[SUP]9[/SUP] This study found that in young mice, long-term exposure to THC “…induced a pro-hallucinogenic molecular conformation of the 5-HT[SUB]2A[/SUB]R.” The researchers also observed “…exacerbated schizophrenia-like responses…” in the mice. These observations of the modification of 5-HT[SUB]2A[/SUB]R by THC is not only a ground-breaking finding but it also adds to the evidence of cannabis being a psychedelic drug based on receptor binding.
Comparing the Effects of Cannabis and Psychedelics
Although the chemistry of the classic psychedelics and the compounds in cannabis are very different from each other, they have remarkably similar effects in many people.
In 1964, the iconic psychedelic researcher and advocate Timothy Leary, along with colleagues Ralph Metzner and Richard Alpert (aka Ram Dass), developed a scale for measuring the intensity of a psychedelic experience.[SUP]10[/SUP] Based on its effects, they included marijuana as a psychedelic in their analysis. The researchers said the effects of moderate to high doses of cannabis included synesthesia, enhanced perception of music, visual effects (including patterns) with the eyes closed, the emergence of unconscious emotions, and unrestrained creative and abstract thought patterns. Many of these effects are common for users of psychedelics taken at low to moderate doses.
Taking higher doses of psychedelics results in out-of-body and mystical experiences for some users along with ego dissolution. Some experts think that cannabis can cause ego dissolution, too. Stephen Gray, editor, and contributor to the book “Cannabis and Spirituality: An Explorer’s Guide to an Ancient Plant Spirit Ally” told PotGuide in an interview that “Cannabis is both gentle and intense. If you take a large enough dosage to actually do that kind of work [achieve ego dissolution], it can be quite powerful.” Gray implies that the ability of cannabis to do this may have a lot to with a person’s intent (part of the set and setting) when taking it.
Summary
Experts consider cannabis a psychedelic drug in terms of its effects and possibly its binding to 5-HT[SUB]2A[/SUB]R. New research is indicating that the psychedelic serotonin 5-HT[SUB]2A[/SUB] receptor may play a role in the adverse effects of chronic cannabis use in adolescents. Although the psychedelic experience can be highly variable, cannabis and psychedelics, in general, have many effects in common.
Overall, it’s important to remember that both cannabis and naturally occurring psychedelics like psilocybin mushrooms (aka magic mushrooms) contain a cocktail of compounds, many of which have not been characterized. Further, understanding the entourage effect in cannabis and magic mushrooms may reveal other similarities in their receptor affinities and effects.
Comments
romanoweed
Well-known member
absolutly agree with this article. Cannabis is hallucinogen . So, its crazy that old Thailines arent around in super Quality. Cause its those types that will cause such reaczions in some
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