THC levels

[Sam_Skunkman]

brainthor,
I suggest you post the link you find the info or at least whom wrote the info originally, and from what book or journal.
I suspect it is from: Marijuana Growers Guide, Frank and Rosenthal?
Most of the last info was correct, except:


"4. Tetrahydrocannabivarin - THCV is the propyl homologue of THC. In the aromatic ring the usual five-carbon pentyl is replaced by a short three-carbon propyl chain. The propyl cannabinoids have so far been found in some varieties originating from Southeast and Central Asia and parts of Africa. What are considered some very potent marijuana varieties contain propyl cannabinoids. In one study, THCV made up to 48.23 percent (Afghanistan strain) and 53.69 percent (South Africa) of the cannabinoids found (136). We've seen no reports on its activity in humans. From animal studies it appears to be much faster in onset and quicker to dissipate than THC (181). It may be the constituent of one- or two-toke grass, but its activity appears to be somewhat less than that of THC."


THCV does not get you high. In fact it is an THC antagonist.
-SamS

 

[Guest]

number4)136. Turner, C.E., Hadley, K.W., and Fetterman, P. 1973. Consituents of Cannabis sativa L., VIropyl Homologues in Sample of Known Geographical Origin. J. Pharm. Sci. 62(10):1739-11741.

181. Gill, E.W., Paton, W.D.M., and Pertwee, R.G. 1970. Preliminary Experiments on Chemistry and Pharmacology of Cannabis. Nature 228:134-136.




no problem...here you go
http://users.lycaeum.org/~sky/data/grow/c2.html

brainthor,
I suggest you post the link you find the info or at least whom wrote the info originally, and from what book or journal.
I suspect it is from: Marijuana Growers Guide, Frank and Rosenthal?
Most of the last info was correct, except:


"4. Tetrahydrocannabivarin - THCV is the propyl homologue of THC. In the aromatic ring the usual five-carbon pentyl is replaced by a short three-carbon propyl chain. The propyl cannabinoids have so far been found in some varieties originating from Southeast and Central Asia and parts of Africa. What are considered some very potent marijuana varieties contain propyl cannabinoids. In one study, THCV made up to 48.23 percent (Afghanistan strain) and 53.69 percent (South Africa) of the cannabinoids found (136). We've seen no reports on its activity in humans. From animal studies it appears to be much faster in onset and quicker to dissipate than THC (181). It may be the constituent of one- or two-toke grass, but its activity appears to be somewhat less than that of THC."


THCV does not get you high. In fact it is an THC antagonist.
-SamS

 

[flux]

man this thread has derailed, anyone care to get back on topic?
Arjans Haze is reported at ~23% THC. long flower period though.

 

[DarkGreen]

Cannabinoids as neuroprotective antioxidants

Cannabinoids as neuroprotective antioxidants

I found this while searching for some medical information about marijuana being neuroprotective. Here's the link:

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=20965

People think that MJ kills brain cells, but this study proves different.

 

[Guest]

People think that MJ kills brain cells,

That came out a while ago or another stating the same thing did, it's not that it kills your brain cells but some pot doesn't allow your thoughts to process as fast, hell sativas help me think

 

[ngakpa]

man this thread has derailed, anyone care to get back on topic?
Arjans Haze is reported at ~23% THC. long flower period though.

the premiss of the thread suggests a basic misconception - hence why it has "derailed", as you put it

THC levels can potentially be a "false friend" in so far as there is a limit to what they tell you about the effect - and not merely qualitatively, but also in terms of basic "potency"

i.e. there is a good reason for it going "off topic", because the topic itself requires doing so - staying in it would be to labour under a misconception, that THC % tells you most of what you need to know

 

[Guest]

13 weeks

man this thread has derailed, anyone care to get back on topic?
Arjans Haze is reported at ~23% THC. long flower period though.

 

[Guest]

6. Cannabinoids do kill brain cells, but the brain cells they kill are called "Glieoma" or Cancer of the brain(Tumor). All other brain cells are protected and healed by cannabinoids. (Glieoma cells cannot tolerate the action of cannabinoids)

 

[Guest]

EVIDENCE FOR SELECTIVE ANTI-TUMOR ACTIVITY OF THC TO BE PUBLISHED IN PRESTIGIOUS NEURO-ONCOLOGY JOURNAL (posted 3.9.05)
SETH scientists discovered that THC, the major active compound in medical marijuana, can selectively kill human brain tumor cells in Petri dishes at non-toxic concentrations (see Featured Experiment). The work has been accepted for publication by the peer-reviewed medical journal, The Journal of Neuro-Oncology, and is expected to be in print later this year. A synthetic compound that mimics the activity of THC did not perform as well as the herbal compound in parallel tests.
http://www.sethgroup.org/

 

[Guest]

Brain Injury Heals With Organ's Version of Pot?

Experiment shows natural brain chemical similar to marijuana may protect nerves

By Neil Sherman
HealthScoutNews Reporter


WEDNESDAY, Oct. 3 (HealthScoutNews) -- A natural brain chemical that's similar to the active ingredient in marijuana may help heal brain injuries, say researchers.

The body's natural version of a cannabinoid, called 2-arachidonoyl glycerol (2-AG), reduced brain swelling, cell death and inflammation in mice with brain injuries, say scientists at Hebrew University in Jerusalem. Animals given 2-AG recovered more of their movement and mental sharpness than those that didn't get it, suggesting a drug made with the cannabinoid one day could be used to treat brain injuries in humans, the researchers say.

Some scientists have done research in the past that seems to show a protective effect -- at least in the test tube -- of THC, marijuana's active ingredient, in brain and nerve injury, says Esther Shohami, associate professor in pharmacology at Hebrew University where THC was first identified in the 1960s. She says because "THC mimics the activities of 2-AG," the researchers decided to use 2-AG in mice to see if it too would protect nerves.

Shohami says the researchers also have identified two natural chemicals -- endogenous cannabinoids -- in the human brain which may play a role in short-term memory, motor coordination, appetite and pain. The findings will appear in the Oct. 4 issue of the journal Nature.

"In a mouse model, we induced [brain] injury similar to those observed in patients. We treated the injured mice once, at one hour after injury, with 2-AG and found that the secondary damage, which is typical after the injury, is reduced," Shohami says. Less water pooled in the brain, there was better recovery of movement, fewer brain cells died and less of the brain was injured, she says.

2-AG may keep the brain from releasing toxic chemicals that cause cell damage and death after an injury, Shohami suggests. It also may improve blood circulation in the brain while slowing the release of chemicals that cause inflammation and cell death after injury. And what happens in a mouse brain also may happen in a human brain, Shohami says. "The basic mechanisms that are activated in the brain are similar between animal and human models."

Brain injury is the major cause of death in the young population in the Western world, Shohami says. "The processes in the brain after trauma that lead to death or injury are only partially understood. After the initial injury, the brain produces compounds which cause further damage, and, at the same time, produces other compounds that may be protective. Apparently the endocannabinoid system is part of this neuroprotective mechanism."

"From a practical point of view, a compound, which reduces the damage caused by brain trauma may be of significant importance in particular since no such drugs are available," Shohami says.

"Although 2-AG is a natural product produced in our brain, further research is needed before we introduce it into clinical use. However, I do believe it is a new avenue that should be pursued by the pharmaceutical industries." Shohami says.

"This is exciting news," says Stanley Thayer, professor of pharmacology at the University of Minnesota Medical School in Minneapolis. "This research highlights how little we know about this endocannabinoid system. What we have here is a dramatic example of how this system may be involved in a response to a traumatic head injury."

"Our treatment of brain injury is very limited. We don't have much we can do to treat trauma, stroke or neurodegenerative disease. So this study shows some potential because it also identifies several potential targets for drug therapies -- not only the brain receptors where the psychoactive ingredient in marijuana, THC, operates. The other targets could be the processes that synthesize and metabolize these molecules like 2-AG."

"Those could be more subtle targets, with fewer side effects," Thayer says.

What To Do: For more on cannabinoids and the brain, see the Society for Neuroscience or the Brain Injury Association of America.


SOURCES: Interviews with Esther Shohami, Ph.D., associate professor, pharmacology, Hebrew University, Jerusalem, Israel, and Stanley Thayer, Ph.D., professor of pharmacology, University of Minnesota Medical School, Minneapolis; Oct. 4, 2001, Nature

Copyright © 2001 ScoutNews, LLC. All rights reserved.

Last updated 10/3/2001.

This article can be accessed directly at:
http://www.healthscout.com/news/1/501938/main.html