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THC levels
- Thread starter JWP
- Start date
JWP
Active member
No replies hmmmm. I thought everyone would be interested in info like this. I’m a stats man myself. Facts and figures comfort me.
Breeders and people hyping up hybrids is great and all but I would really love some scientific evidence to go along with it.
I realize that these sorts of numbers aren’t everything but I would have to say that this sort of info would be just as important if not more than all the opinions of people put together.
Edit: I mean measurement of as many cannaboids as possible. I’m sure people are interested in strains with high CBN levels just as much as THC.
Breeders and people hyping up hybrids is great and all but I would really love some scientific evidence to go along with it.
I realize that these sorts of numbers aren’t everything but I would have to say that this sort of info would be just as important if not more than all the opinions of people put together.
Edit: I mean measurement of as many cannaboids as possible. I’m sure people are interested in strains with high CBN levels just as much as THC.
Last edited:
i don't worry to much about the levels i just like what makes me feel how i like to feel.
but as far as potency goes lots of great strains out there with high thc levels..
i think more and more we are finding that the other degraded cannabinoids like cbn cbd are just going to block thc uptake.. and the actual profiles of the way different buds make us 'feel' may not only be about the cannabinoid ratios and percentages but also about the terpenes and flavonoids.. and the way we tie smells to feelings..
but yeah high thc percentages doesn't seem to hurt anything haha
but as far as potency goes lots of great strains out there with high thc levels..
i think more and more we are finding that the other degraded cannabinoids like cbn cbd are just going to block thc uptake.. and the actual profiles of the way different buds make us 'feel' may not only be about the cannabinoid ratios and percentages but also about the terpenes and flavonoids.. and the way we tie smells to feelings..
but yeah high thc percentages doesn't seem to hurt anything haha
Last edited:
JWP
Active member
Yeah high THC levels don’t hurt lol
It’s my understanding that CBN really is necessary as it has a calming effect on THC. I didn’t know it blocked THC.
On terpenoids & flavonoids. Would you “feel” less or more happy if they weren’t present? Like with a water cure your terpenoids flavonoids would be less and your cannaboid levels would be higher. If it was a blind test and you didn’t know which was which, a cone was packed for you and you smoked away is the taste and smell really part of what makes you feel good or is it a higher THC level?
It’s my understanding that CBN really is necessary as it has a calming effect on THC. I didn’t know it blocked THC.
On terpenoids & flavonoids. Would you “feel” less or more happy if they weren’t present? Like with a water cure your terpenoids flavonoids would be less and your cannaboid levels would be higher. If it was a blind test and you didn’t know which was which, a cone was packed for you and you smoked away is the taste and smell really part of what makes you feel good or is it a higher THC level?
yeah it seems weird but check out this thread.. especially sam_skunkman's posts.. really interesting work he's done sampling the pure extracts of some of the key players in this exploration for 'what is it exactly that makes you feel differently from smoking different kinds of pot'
http://www.icmag.com/ic/showthread.php?t=29293&page=1&pp=15
http://www.icmag.com/ic/showthread.php?t=29293&page=1&pp=15
G
Guest
couldnt resist
The Cannabinoid System has been around for over 600 million years. Before the Dinosaurs. The Cannabinoid System is continuously evolutioning and has been retained by all new species. Food and feeding is at the heart of the Cannabinoid System.
1. Cannabinoids are in every living animal on the planet above Hydra and Mollusks, with the exception of insects. Bodies are homeostatically maintained by the Cannabinoid System.
2. Mothers give their babies a booster shot of cannabinoids in mothers milk to give them the munchies because they have to learn to eat. (they've been fed thru the umbilical cord and did not have to know how to eat.)
3. Mice lacking the CB1 receptors don't like any changes. If they are moved to another part of the cage they act upset and when they are put back to the original spot in the cage they relax, but if then put into another part of the cage they get upset again. Comment: I wonder if people, especially drug warriors, had their CB1 receptors blocked then they would resist change and the ones of us that have unblocked CB1 receptors enjoy the benefits of cannabinoids are a lot more relaxed and not paranoid about or over change. Interesting thought. It turns out that that thought is absolutely correct. Many people' brains are not capable of a good connection to the CB1 CB2 receptors.
4. All new species utilize cannabinoids.
5. By being alive and breathing air our bodies produce "free radicals". Cannabinoids help to reverse this action.
6. Cannabinoids do kill brain cells, but the brain cells they kill are called "Glioma" or Cancer of the brain(Tumor). All other brain cells are protected and healed by cannabinoids. (Glioma cells cannot tolerate the action of cannabinoids)
7. Cannabinoids protect against sunburn and skin cancer because of the CB1 receptors in our skin.
8. Cannabinoids slow down the aging process. Mice that their brains respond to cannabinoids live longer and mice that have brains that block the CB1 receptors die younger.
9. Activity in the evolutionary advanced areas of the brain is increased in cannabinoids receptors and promotes higher consciousness levels.
10. Cannabinoids are even found in the white blood cells (CB2 receptors). The CB2 receptors are found predominantly on immunological cells and regulate the shift in the immune system to the anti-inflammatory mode.
11. Cannabinoids protect the heart against Arythmia.
12. The way it works on pain is there is specific nerves that deal with pain. They are called vanilloid-Receptors. Anandamide(sanscript word for "Blissful Amide"), the bodies internally produced marijuana binds with the nerve endings, reducing pain. Anandamides are produced internally by our bodies in response to a whole variety of conditions. As an example, Aspirin prevents the breakdown of Anandamide, the internally produced marijuana to activate & start working at easing pain. How many old lady's say they "WOULD NEVER" use marijuana & are actually using the equivalent of marijuana that their bodies produce as a natural activity, & don't even realize it. And how many politicians and citizens of the US do this also & aren't even aware they are condemning something that their bodies make naturally. Anecdotal evidence is valid because when a person smokes marijuana & it relieves their pain, then they smoke it again & it relieves their pain again it becomes a fact known only to that person, but nonetheless true.
13. In the case of most autoimmune diseases, the bodies immune cells produces free radicals & is destroying it's own body as a foreign object. Cannabis pushes the immune system into anti inflammatory mode & helps slow the progression of that disease, thereby slowing down the aging process.
14. Seizures are controlled by marijuana not only THC, but non-psychoactive cannabidiol.(CBD) The exact mechanism is not known, however HEMP is high in CBD's & can cancel out the psychoactive high of THC & at the same time benefits the user or smoker. Cannabinoids control everything in our bodies including our minds.
15. There are many other things that Cannabinoids do in the body, besides attaching to the CB1 and CB2 receptors, the main cannabinoid receptors in the higher part of our brain. Cannabinoids affect our skin and other parts of our bodies.
16. Pharmaceutical companies are working at sythesizing different cannabinoid components and different types of strains of marijuana. If they can succeed, then there will be more choices for you and I to choose from and we will be able to use what works best for our particular bodies.
17. The natural course for mankind, because of the location of our CB1 CB2 the brains main receptors, is to be more stoned.
18. Drug warriors are not doing what they are doing to us because they are intentionally evil, but because they are more primitive(obtuse comes to mind). They look at the world with fear and hostility not cooperativity and understanding.
19. According to a brain function study of 150 depressed people Cannabis protects the brain against healthy cell death and it also protects Neurons.
20. Cannabinoids dilate our brochial tubes and help asthsma sufferers to breath both in and out. Because of the balance that is maintained in our bodies for good health there are instances where it works backwards, where death is possible, if too much is smoked. This goes back to the effects of cannabinoids on individuals and if it doesn't work for you, you should not use it. There was some old studies that were done back in 1977 where "AEROSOLIZED THC" was used on patients. This is not what the government tells us when they say it's not medicine, but we are all familiar with the 7 government patients that are supplied marijuana to be used as medicine and we know the government is lying.
21. Natural pain eradication by cannabinol used by our receptors.
22. Cannabinoids control how we view the future. If you're loaded with bad experiences you're going to be fearful of the future. Lots of smoking of cannabinoids makes you want to be in the future. Lack of change vs embracing the future and changes. Conservative people might die prematurely, stressed, uptight and fearful (genocide). Open minded people and mice are able to change, whereas; people with defective receptors and knock-out mice (mice that have had their receptors removed) will keep going to the platform after it has been removed. They will be fearful of change.
23. Cannabinoids prevent and treat certain types of Cancer. Glioma (Brain Cancer) along with pheochromocytoma, skin cancer, prostate cancer, breast cancer, Lymphoma and Leukemia. Cannabinoids may prevent or cure cancer. Cannabinoids have a way of killing the bad cells and protecting the good ones.
24. Cannabis gives relief to Liver Disease & constant uncontrollable itching. Also, lack of sleep and depression and has been doing so for 600 million years.
25. THC in low doses relieves anxiety, while huge doses promote anxiety. (It's too strong like Marinol) Smoking marijuana relieves anxiety. Marijuana promotes sleeping better and normal persons when they are deprived of marijuana would have difficulty sleeping. (One other thing I'd like to add: When ingested, delta 9 THC, on the first pass thru the liver, changes into delta 11 THC. Five times as psychoactive and much longer lasting. I don't know how many people understand that. Ralph)
26. Cannabis protects nerve cells from dying thus protects against Altzheimers Disease.
27. Our bodies make up marijuana like compounds to make us hungry. (gives us the munchies) Then turn off those compounds & we don't have the munchies anymore when it has had enough food. The cannabinoid system first appeared 600 million years ago. Food & feeding is at the heart of evolution & the development of new species.
28. Head injuries cause the body to produce Endo-cannabinoids to protect itself as well as protecting the body against Nerve Gas. Marijuana turns on the bodies Protective Mode, because when you're hungry the body makes Cannabinoids to turn on your hunger. Cannabinoids turn on the expression of a Particular Gene (at the same time it prevents the expression of other Genes). How the Marijuana Receptors change the Integral Bio-Chemistry. Some of the Molecules that are involved or been studied in a Model Organism. There is a worm that people study alot. They have very simple Nervous Systems so you can define what exactly is going on. It turns out this one Particular Molecule regulates what is known as a Transcription Factor (It turns on the Expression of Genes.) It turns out that when you turn on the Expression of this Particular Gene of the Worm Model it actually promotes Mimicking a condition that actually Promotes Longevity of these worms. This Parallels what we've seen in mice. Because Marijuana exhibits Free Radicals so people who've been using Cannabis, Long Term, tend to Live Longer & Look Younger. Marijuana Promotes your Health by affecting your Nerve Cells, by Balancing your Immune System, by Reducing Fat Deposition in your Cardio-Vascular System. It looks as if it helps Burn the Synthesis of things like Cholesterol.
29. New research shows that the argument over outlawing cannabis because it "Causes Cancer" is no longer valid. There are Nicotine Receptors in your throat. There are no Cannabinoid Receptors in your throat. Cells have a Bio-chemical Program known as "APOPTOSIS". This Bio-chemical Program is activated when cells too damaged to repair themselves commit suicide. There is a Bio-chemical Pathway that controls that. Nicotine activates a path that protects the cells from dying. Smoking anything puts Carcinogens into your Air Passage-ways and Cardio-Vascular system. Cells that get damaged by smoke die and that's what you want to happen. Cells to die before they become Cancer Cells.
30. Cannabinoids modulate pain peripherally. In our bodies there are special kinds of pain receptors, known as Vanaloid receptors & they are sensitive to things like heat & excessive pressure & they are responsible for pain. It turns out that a natural regulator of that that down-regulates pain. The endocannabinoid known as Anandamide, the blissful amide, when you combine Sanskrit for ananda & amide for the chemical type. It's clearly known that cannabis can regulate pain, that's been done in numerous studies, but recently , as we learn more about the molecular mechanisms of pain & cannabinoid action what we have now learned is that there is a lot of crosstalk between the cannabinoid system & the morphine, the opioid system. The name of an article that just came out is called Chronic morphine modulates the contents of the endocannabinoid tuorachidonalglycerol in the rat brain. So, tuorachidonalglycerol is another endocannabinoid. We feel pain thru the sensory nerves that are telling us that we're in a painful situation & on the other hand we feel it within our minds because certain areas of our brain subsequently get tickled. What we are seeing now is that the cannabinoid system works both peripherally & centrally & what we are gonna talk about here is this new work that links the cannabinoids more with the opioids in that opioids & cannabinoids are among the most widely consumed drugs of abuse in humans & phenomena of cross-tolerations or mutual potentiation demonstrated between these two drugs. Some of the recent work on pain has come out of England as a result of work done by G.W. Pharmaceuticals which is a company that specializes in producing cannabis plants. They've developed different strains that have different ratios of the cannabinoids & those different plants have different properties. In the past I've mentioned Bi-Polar disorder. Some people who are Bi-Polar & are depressive find Sativa's are good to help elevate them & if they're in an elevated mood & in a manic state they have to be brought down alittle & the Indica's seem to be better for that & likewise they're different ratio's of these cannabinoids that are thought to benefit for example pain, more than others, that are thought to benefit auto-immune diseases. This is being worked out, but what I'd like to go into now is that some of the new links that seem to be occurring in this particular study that I just mentioned, what they are finding is that chronic administration of Opioids is in fact down-regulating the tuorachidonalglycerol which as mentioned, is one of the endo-cannabinoids. Interestingly the Anandamide level seem to be remaining the same, but this other one, tuorachidonalglycerol seems to be down-regulated. In knock-out mice, these are mice where a particular gene is missing, it turns out that you can eliminate alot of the withdrawal systems associated with opium if you have knocked out the receptors. When people go thru withdrawal, they get terribly nauseous & feel horribly sick, well, what we do know cannabinoids control nausea. That's why it's being used by people who are receiving Chemo-therapy or disorders where they are chronically nauseous. Cannabinoids can be very effective for that. So what we are seeing is that morphine turns down the Endogenous cannabinoid Arachidonic acid & that seems to be involved in some of the addictive behavior & this is kind of interesting because we know that cannabinoids themselves other than very twisted circumstances do not show addictive behavior. On the one hand we have the cannabinoid potentiating the morphine, in that people who need morphine for pain can often use 50% of what they normally use by including cannabinoids & on the other hand, we're seeing that the cannabinoid receptor system is involved in addiction & I mentioned a long time ago, that cannabinoids can be beneficial for some people in their attempt to withdraw & now we're seeing support for that in that chronic morphine administration is turning off one of the cannabinoids that's in turn, turning on some of the withdrawal systems.
31. Cannabinoids represent a general class of chemicals, not just cannabis & THC in plants, but rather also cannabinoids that are produced in our bodies. These happen to be Lipid compounds that result from burning & making fats. The thing that is so unique about this system represents how it works so broadly for various health reasons. That is that every single system in our bodies & by system I mean our nervous system or digestive system or reproductive system or immunological system or endocrine system, you name it & the cannabinoids are involved in maintaining what's known as homostasis balance. We need to have the right amount of these components of this system which includes the compounds like THC which is better known as Lygan. They bind to specific receptors & then they are broken down by another enzyme that breaks down these things. So, we have a whole network of bio-chemistry that's influencing everything in our bodies. The question that arises is that the whole is always greater than the sum of its parts. The system, the cannabinoid system influencing everything in our bodies & the question is what are the nature of the wholes? What are the greater pictures that emerge out of this cannabinoid systems activity. So we see, for example, regulating reproductive system, digestive system, immune system & when they are all working together in a way that is concertedly modulated by the cannabinoid system what can we expect to see, & I would suggest that what's represented by the influences of cannabinoids & cannabis on our mind, in that it opens up our minds to new ways of thinking, it free's us from being stuck in a single track of thinking & that's exactly the kind of thought processes that are required as we move into the future which is generally composed of the unknown. What the cannabinoid system is doing is giving us a way to peacefully & lovingly adapt to change & be open to change. We see in these mice that we can knock-out the cannabinoid system that they are afraid of change. The implications of this are really profound if in fact we have people that are shifted one way or the other in terms of their ability to modulate & accept change that is of profound importance because we see people that are afraid to look forward, happily embracing the future. There are health ramifications for all of this. The cannabinoid system can help us with cardio-vascular disease where it reduces infarctsize with auto-immune diseases where it helps ameliorate & prevent the development of a whole variety of auto-immune diseases including things like arthritis, multiple sclerosis, diabetes, crones disease & it's also involved with, as a natural regulator of our pain. So we have this holistic medicine that's influencing so many things & I forgot to mention that it regulates our memories & mental pains & in fact, regulates alot of life/death decisions in our cells, nerve cells in particular, which is why it's so beneficial for neurological disorders often associated with the aging, such as Alzheimer's disease. What we're seeing is a holistic medicine & again it has to be used appropriately, too little is no good, & we may be making enough. Individuals may be making enough, but there could be many many people who are not making enough or their system is not active enough who will be able to benefit from the use of cannabis & other cannabinoids. To regulate all of the things we've mentioned that it regulates. So, we've got a holistic health program. To find the balance that's required for our optimum health is something that's totally built into the cannabinoid system. Therefore, it should be readily available to use wisely
Dr. Robert Melamede, Ph.D.
Dr. Robert J. Melamede Ph.D. Chairman of the Biology Department of the University of Colorado:
Conducting Scientific research on Cannabinoids
Phone: 719-262-3135
University of Colorado
1420 Austin Bluffs Parkway
Room 232
PO Box 7150
Colorado Springs, CO 80933-7150
[email protected]
The Cannabinoid System has been around for over 600 million years. Before the Dinosaurs. The Cannabinoid System is continuously evolutioning and has been retained by all new species. Food and feeding is at the heart of the Cannabinoid System.
1. Cannabinoids are in every living animal on the planet above Hydra and Mollusks, with the exception of insects. Bodies are homeostatically maintained by the Cannabinoid System.
2. Mothers give their babies a booster shot of cannabinoids in mothers milk to give them the munchies because they have to learn to eat. (they've been fed thru the umbilical cord and did not have to know how to eat.)
3. Mice lacking the CB1 receptors don't like any changes. If they are moved to another part of the cage they act upset and when they are put back to the original spot in the cage they relax, but if then put into another part of the cage they get upset again. Comment: I wonder if people, especially drug warriors, had their CB1 receptors blocked then they would resist change and the ones of us that have unblocked CB1 receptors enjoy the benefits of cannabinoids are a lot more relaxed and not paranoid about or over change. Interesting thought. It turns out that that thought is absolutely correct. Many people' brains are not capable of a good connection to the CB1 CB2 receptors.
4. All new species utilize cannabinoids.
5. By being alive and breathing air our bodies produce "free radicals". Cannabinoids help to reverse this action.
6. Cannabinoids do kill brain cells, but the brain cells they kill are called "Glioma" or Cancer of the brain(Tumor). All other brain cells are protected and healed by cannabinoids. (Glioma cells cannot tolerate the action of cannabinoids)
7. Cannabinoids protect against sunburn and skin cancer because of the CB1 receptors in our skin.
8. Cannabinoids slow down the aging process. Mice that their brains respond to cannabinoids live longer and mice that have brains that block the CB1 receptors die younger.
9. Activity in the evolutionary advanced areas of the brain is increased in cannabinoids receptors and promotes higher consciousness levels.
10. Cannabinoids are even found in the white blood cells (CB2 receptors). The CB2 receptors are found predominantly on immunological cells and regulate the shift in the immune system to the anti-inflammatory mode.
11. Cannabinoids protect the heart against Arythmia.
12. The way it works on pain is there is specific nerves that deal with pain. They are called vanilloid-Receptors. Anandamide(sanscript word for "Blissful Amide"), the bodies internally produced marijuana binds with the nerve endings, reducing pain. Anandamides are produced internally by our bodies in response to a whole variety of conditions. As an example, Aspirin prevents the breakdown of Anandamide, the internally produced marijuana to activate & start working at easing pain. How many old lady's say they "WOULD NEVER" use marijuana & are actually using the equivalent of marijuana that their bodies produce as a natural activity, & don't even realize it. And how many politicians and citizens of the US do this also & aren't even aware they are condemning something that their bodies make naturally. Anecdotal evidence is valid because when a person smokes marijuana & it relieves their pain, then they smoke it again & it relieves their pain again it becomes a fact known only to that person, but nonetheless true.
13. In the case of most autoimmune diseases, the bodies immune cells produces free radicals & is destroying it's own body as a foreign object. Cannabis pushes the immune system into anti inflammatory mode & helps slow the progression of that disease, thereby slowing down the aging process.
14. Seizures are controlled by marijuana not only THC, but non-psychoactive cannabidiol.(CBD) The exact mechanism is not known, however HEMP is high in CBD's & can cancel out the psychoactive high of THC & at the same time benefits the user or smoker. Cannabinoids control everything in our bodies including our minds.
15. There are many other things that Cannabinoids do in the body, besides attaching to the CB1 and CB2 receptors, the main cannabinoid receptors in the higher part of our brain. Cannabinoids affect our skin and other parts of our bodies.
16. Pharmaceutical companies are working at sythesizing different cannabinoid components and different types of strains of marijuana. If they can succeed, then there will be more choices for you and I to choose from and we will be able to use what works best for our particular bodies.
17. The natural course for mankind, because of the location of our CB1 CB2 the brains main receptors, is to be more stoned.
18. Drug warriors are not doing what they are doing to us because they are intentionally evil, but because they are more primitive(obtuse comes to mind). They look at the world with fear and hostility not cooperativity and understanding.
19. According to a brain function study of 150 depressed people Cannabis protects the brain against healthy cell death and it also protects Neurons.
20. Cannabinoids dilate our brochial tubes and help asthsma sufferers to breath both in and out. Because of the balance that is maintained in our bodies for good health there are instances where it works backwards, where death is possible, if too much is smoked. This goes back to the effects of cannabinoids on individuals and if it doesn't work for you, you should not use it. There was some old studies that were done back in 1977 where "AEROSOLIZED THC" was used on patients. This is not what the government tells us when they say it's not medicine, but we are all familiar with the 7 government patients that are supplied marijuana to be used as medicine and we know the government is lying.
21. Natural pain eradication by cannabinol used by our receptors.
22. Cannabinoids control how we view the future. If you're loaded with bad experiences you're going to be fearful of the future. Lots of smoking of cannabinoids makes you want to be in the future. Lack of change vs embracing the future and changes. Conservative people might die prematurely, stressed, uptight and fearful (genocide). Open minded people and mice are able to change, whereas; people with defective receptors and knock-out mice (mice that have had their receptors removed) will keep going to the platform after it has been removed. They will be fearful of change.
23. Cannabinoids prevent and treat certain types of Cancer. Glioma (Brain Cancer) along with pheochromocytoma, skin cancer, prostate cancer, breast cancer, Lymphoma and Leukemia. Cannabinoids may prevent or cure cancer. Cannabinoids have a way of killing the bad cells and protecting the good ones.
24. Cannabis gives relief to Liver Disease & constant uncontrollable itching. Also, lack of sleep and depression and has been doing so for 600 million years.
25. THC in low doses relieves anxiety, while huge doses promote anxiety. (It's too strong like Marinol) Smoking marijuana relieves anxiety. Marijuana promotes sleeping better and normal persons when they are deprived of marijuana would have difficulty sleeping. (One other thing I'd like to add: When ingested, delta 9 THC, on the first pass thru the liver, changes into delta 11 THC. Five times as psychoactive and much longer lasting. I don't know how many people understand that. Ralph)
26. Cannabis protects nerve cells from dying thus protects against Altzheimers Disease.
27. Our bodies make up marijuana like compounds to make us hungry. (gives us the munchies) Then turn off those compounds & we don't have the munchies anymore when it has had enough food. The cannabinoid system first appeared 600 million years ago. Food & feeding is at the heart of evolution & the development of new species.
28. Head injuries cause the body to produce Endo-cannabinoids to protect itself as well as protecting the body against Nerve Gas. Marijuana turns on the bodies Protective Mode, because when you're hungry the body makes Cannabinoids to turn on your hunger. Cannabinoids turn on the expression of a Particular Gene (at the same time it prevents the expression of other Genes). How the Marijuana Receptors change the Integral Bio-Chemistry. Some of the Molecules that are involved or been studied in a Model Organism. There is a worm that people study alot. They have very simple Nervous Systems so you can define what exactly is going on. It turns out this one Particular Molecule regulates what is known as a Transcription Factor (It turns on the Expression of Genes.) It turns out that when you turn on the Expression of this Particular Gene of the Worm Model it actually promotes Mimicking a condition that actually Promotes Longevity of these worms. This Parallels what we've seen in mice. Because Marijuana exhibits Free Radicals so people who've been using Cannabis, Long Term, tend to Live Longer & Look Younger. Marijuana Promotes your Health by affecting your Nerve Cells, by Balancing your Immune System, by Reducing Fat Deposition in your Cardio-Vascular System. It looks as if it helps Burn the Synthesis of things like Cholesterol.
29. New research shows that the argument over outlawing cannabis because it "Causes Cancer" is no longer valid. There are Nicotine Receptors in your throat. There are no Cannabinoid Receptors in your throat. Cells have a Bio-chemical Program known as "APOPTOSIS". This Bio-chemical Program is activated when cells too damaged to repair themselves commit suicide. There is a Bio-chemical Pathway that controls that. Nicotine activates a path that protects the cells from dying. Smoking anything puts Carcinogens into your Air Passage-ways and Cardio-Vascular system. Cells that get damaged by smoke die and that's what you want to happen. Cells to die before they become Cancer Cells.
30. Cannabinoids modulate pain peripherally. In our bodies there are special kinds of pain receptors, known as Vanaloid receptors & they are sensitive to things like heat & excessive pressure & they are responsible for pain. It turns out that a natural regulator of that that down-regulates pain. The endocannabinoid known as Anandamide, the blissful amide, when you combine Sanskrit for ananda & amide for the chemical type. It's clearly known that cannabis can regulate pain, that's been done in numerous studies, but recently , as we learn more about the molecular mechanisms of pain & cannabinoid action what we have now learned is that there is a lot of crosstalk between the cannabinoid system & the morphine, the opioid system. The name of an article that just came out is called Chronic morphine modulates the contents of the endocannabinoid tuorachidonalglycerol in the rat brain. So, tuorachidonalglycerol is another endocannabinoid. We feel pain thru the sensory nerves that are telling us that we're in a painful situation & on the other hand we feel it within our minds because certain areas of our brain subsequently get tickled. What we are seeing now is that the cannabinoid system works both peripherally & centrally & what we are gonna talk about here is this new work that links the cannabinoids more with the opioids in that opioids & cannabinoids are among the most widely consumed drugs of abuse in humans & phenomena of cross-tolerations or mutual potentiation demonstrated between these two drugs. Some of the recent work on pain has come out of England as a result of work done by G.W. Pharmaceuticals which is a company that specializes in producing cannabis plants. They've developed different strains that have different ratios of the cannabinoids & those different plants have different properties. In the past I've mentioned Bi-Polar disorder. Some people who are Bi-Polar & are depressive find Sativa's are good to help elevate them & if they're in an elevated mood & in a manic state they have to be brought down alittle & the Indica's seem to be better for that & likewise they're different ratio's of these cannabinoids that are thought to benefit for example pain, more than others, that are thought to benefit auto-immune diseases. This is being worked out, but what I'd like to go into now is that some of the new links that seem to be occurring in this particular study that I just mentioned, what they are finding is that chronic administration of Opioids is in fact down-regulating the tuorachidonalglycerol which as mentioned, is one of the endo-cannabinoids. Interestingly the Anandamide level seem to be remaining the same, but this other one, tuorachidonalglycerol seems to be down-regulated. In knock-out mice, these are mice where a particular gene is missing, it turns out that you can eliminate alot of the withdrawal systems associated with opium if you have knocked out the receptors. When people go thru withdrawal, they get terribly nauseous & feel horribly sick, well, what we do know cannabinoids control nausea. That's why it's being used by people who are receiving Chemo-therapy or disorders where they are chronically nauseous. Cannabinoids can be very effective for that. So what we are seeing is that morphine turns down the Endogenous cannabinoid Arachidonic acid & that seems to be involved in some of the addictive behavior & this is kind of interesting because we know that cannabinoids themselves other than very twisted circumstances do not show addictive behavior. On the one hand we have the cannabinoid potentiating the morphine, in that people who need morphine for pain can often use 50% of what they normally use by including cannabinoids & on the other hand, we're seeing that the cannabinoid receptor system is involved in addiction & I mentioned a long time ago, that cannabinoids can be beneficial for some people in their attempt to withdraw & now we're seeing support for that in that chronic morphine administration is turning off one of the cannabinoids that's in turn, turning on some of the withdrawal systems.
31. Cannabinoids represent a general class of chemicals, not just cannabis & THC in plants, but rather also cannabinoids that are produced in our bodies. These happen to be Lipid compounds that result from burning & making fats. The thing that is so unique about this system represents how it works so broadly for various health reasons. That is that every single system in our bodies & by system I mean our nervous system or digestive system or reproductive system or immunological system or endocrine system, you name it & the cannabinoids are involved in maintaining what's known as homostasis balance. We need to have the right amount of these components of this system which includes the compounds like THC which is better known as Lygan. They bind to specific receptors & then they are broken down by another enzyme that breaks down these things. So, we have a whole network of bio-chemistry that's influencing everything in our bodies. The question that arises is that the whole is always greater than the sum of its parts. The system, the cannabinoid system influencing everything in our bodies & the question is what are the nature of the wholes? What are the greater pictures that emerge out of this cannabinoid systems activity. So we see, for example, regulating reproductive system, digestive system, immune system & when they are all working together in a way that is concertedly modulated by the cannabinoid system what can we expect to see, & I would suggest that what's represented by the influences of cannabinoids & cannabis on our mind, in that it opens up our minds to new ways of thinking, it free's us from being stuck in a single track of thinking & that's exactly the kind of thought processes that are required as we move into the future which is generally composed of the unknown. What the cannabinoid system is doing is giving us a way to peacefully & lovingly adapt to change & be open to change. We see in these mice that we can knock-out the cannabinoid system that they are afraid of change. The implications of this are really profound if in fact we have people that are shifted one way or the other in terms of their ability to modulate & accept change that is of profound importance because we see people that are afraid to look forward, happily embracing the future. There are health ramifications for all of this. The cannabinoid system can help us with cardio-vascular disease where it reduces infarctsize with auto-immune diseases where it helps ameliorate & prevent the development of a whole variety of auto-immune diseases including things like arthritis, multiple sclerosis, diabetes, crones disease & it's also involved with, as a natural regulator of our pain. So we have this holistic medicine that's influencing so many things & I forgot to mention that it regulates our memories & mental pains & in fact, regulates alot of life/death decisions in our cells, nerve cells in particular, which is why it's so beneficial for neurological disorders often associated with the aging, such as Alzheimer's disease. What we're seeing is a holistic medicine & again it has to be used appropriately, too little is no good, & we may be making enough. Individuals may be making enough, but there could be many many people who are not making enough or their system is not active enough who will be able to benefit from the use of cannabis & other cannabinoids. To regulate all of the things we've mentioned that it regulates. So, we've got a holistic health program. To find the balance that's required for our optimum health is something that's totally built into the cannabinoid system. Therefore, it should be readily available to use wisely
Dr. Robert Melamede, Ph.D.
Dr. Robert J. Melamede Ph.D. Chairman of the Biology Department of the University of Colorado:
Conducting Scientific research on Cannabinoids
Phone: 719-262-3135
University of Colorado
1420 Austin Bluffs Parkway
Room 232
PO Box 7150
Colorado Springs, CO 80933-7150
[email protected]
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JWP
Active member
Lots of good info there. And its all great reading. Will keep me busy for a long time to come im sure.
Until we have some sort of cannabinoid profile database as THCV was suggesting in that other thread its still going to be trial and error for me.
The problem is I only have one lifetime and that’s why I wanted to at least get some sort of list underway here.
Until we have some sort of cannabinoid profile database as THCV was suggesting in that other thread its still going to be trial and error for me.
The problem is I only have one lifetime and that’s why I wanted to at least get some sort of list underway here.
G
Guest
just smoke everything you can...dont pass up something because the thc levels are not 20%..cannabinoids effect the high..in other words smoke them all then decide what you want to grow..the equation of thc and cannibinoids is different in different individuals..
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THC level is really only a good measurement with clones as seed stock usually has a large variablility of THC level. One pheno might have a high THC, and another not as high. I guess if the THC level is high, then your bound to get a higher THC level on average, so I guess it still means something......sorry, just stoned talk, i'm going back to sleep.
TGT
TGT
brainthor,
If you say that anandamide is a Cannabinoid then what you say is correct, but I would not say that Anandamide is a Cannabinoid. Cannabinoids are produced by Cannabis plants and Cannabis plants do not produce Anandamide.
"Cannabis gives relief to Liver Disease & constant uncontrollable itching. Also, lack of sleep and depression and has been doing so for 600 million years."
Are you sure people were around 600 million years ago? Or Cannabis plants? Do you have any proof?
11Hydroxy is not 5 times as strong as THC. Maybe 2.5 times as strong.
"Cannabinoids represent a general class of chemicals, not just cannabis & THC in plants, but rather also cannabinoids that are produced in our bodies."
Cannabinoids are not produced in the body. Anandamide is, but Anandamide is not a Classical Cannabinoid as far as I understand. Anadamide is a Endogenous Cannabinoid or Endocannabinoid at best. If clarity is sought then maybe the terms Classical Cannabinoids or PhytoCannabinoids for Cannabis plant derived materials and for non Cannabis plant derived Endocannabinoids should be used? As well as both natural and synthesized versions of the above there are the synthetic analogues of both, which are not found in Man or plants, but are a creation of men.
If you check the literature about the number of Cannabinoids you will find 66 identified, Anadamide, is not listed. Why?
-SamS
If you say that anandamide is a Cannabinoid then what you say is correct, but I would not say that Anandamide is a Cannabinoid. Cannabinoids are produced by Cannabis plants and Cannabis plants do not produce Anandamide.
"Cannabis gives relief to Liver Disease & constant uncontrollable itching. Also, lack of sleep and depression and has been doing so for 600 million years."
Are you sure people were around 600 million years ago? Or Cannabis plants? Do you have any proof?
11Hydroxy is not 5 times as strong as THC. Maybe 2.5 times as strong.
"Cannabinoids represent a general class of chemicals, not just cannabis & THC in plants, but rather also cannabinoids that are produced in our bodies."
Cannabinoids are not produced in the body. Anandamide is, but Anandamide is not a Classical Cannabinoid as far as I understand. Anadamide is a Endogenous Cannabinoid or Endocannabinoid at best. If clarity is sought then maybe the terms Classical Cannabinoids or PhytoCannabinoids for Cannabis plant derived materials and for non Cannabis plant derived Endocannabinoids should be used? As well as both natural and synthesized versions of the above there are the synthetic analogues of both, which are not found in Man or plants, but are a creation of men.
If you check the literature about the number of Cannabinoids you will find 66 identified, Anadamide, is not listed. Why?
-SamS
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hey - I'm not sure high THC levels are even necessarily what you are after
http://www.icmag.com/ic/showthread.php?t=29254&page=4&pp=15
at the end of the day, its the complete resin profile that matters, see in particular post #59
http://www.icmag.com/ic/showthread.php?t=29254&page=4&pp=15
at the end of the day, its the complete resin profile that matters, see in particular post #59
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JWP... instead of THC levels I just look at the type of high it produces..
Like White russian is said to be tested at 21%..but if you are looking for a couchlock your wasting your time with her..body stone but motivating high.
Then theres a Hindu kush thats say test at 12% but locks you to the couch...
#'s only matter when counting the days till you get out of jail...
Like White russian is said to be tested at 21%..but if you are looking for a couchlock your wasting your time with her..body stone but motivating high.
Then theres a Hindu kush thats say test at 12% but locks you to the couch...
#'s only matter when counting the days till you get out of jail...
JWP
Active member
Hey guys thanks for stopping by.
ngakpa: Its funny that you should mention that thread and post # because SamS says: “The bottom line is you want lots of taste and smells, it is what makes the highs so great and unique and individual.”
At first glance it appears that what he is saying is totally contradicting my personal findings experienced with a water cure. Where taste & smell are pretty much gone. But the high I experience is clearly better than air dried and cured buds of the same harvest.
But in the same post he says: “I just meant resin with the right terpenoids that you prefer”
This leads me to the conclusion that I prefer a higher level of THC with a lower level of terpenoids.
Which takes us rite back to the idea of a cannabinoid profile database…..
Edit: You know what i mean? High levels or low levels, it doesn’t really matter. What matters is being able to identify which is rite for me and then being able to select strains in that range.
At first I would like to know strains with high levels of THC but other information is just as important and worth knowing.
ngakpa: Its funny that you should mention that thread and post # because SamS says: “The bottom line is you want lots of taste and smells, it is what makes the highs so great and unique and individual.”
At first glance it appears that what he is saying is totally contradicting my personal findings experienced with a water cure. Where taste & smell are pretty much gone. But the high I experience is clearly better than air dried and cured buds of the same harvest.
But in the same post he says: “I just meant resin with the right terpenoids that you prefer”
This leads me to the conclusion that I prefer a higher level of THC with a lower level of terpenoids.
Which takes us rite back to the idea of a cannabinoid profile database…..
Edit: You know what i mean? High levels or low levels, it doesn’t really matter. What matters is being able to identify which is rite for me and then being able to select strains in that range.
At first I would like to know strains with high levels of THC but other information is just as important and worth knowing.
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Dutch Passion's Powerplant is advertized by DP as "rich in THC", (15% according to their gas chromatography tests, for whatever that is worth). The high is a warm, energized sativa buzz. Recommended.
G
Guest
How old is the human race?
Author: 29561 Category
Discussion) Created3/23/2001 12:39:00 PM) Viewed (3317 times)
Humans are currently thought to have emerged between 1 and 2 million years ago, but recent findings may prove that man is much older then that.
What may be the oldest fossil footprint yet found was discovered in June of 1968 by William J. Meister, an amateur fossil collector. This print is estimated to be around 300 to 600 MILLION years old! A sandaled shoe crushing a trilobite; is this proof that there were previous civilizations on earth, or visitors from another world? Could this foot print be from God? The sandal that crushed a living trilobite was 10 1/2 inches long and 3 1/2 inches wide; the heel is indented slightly more than the sole, as a human shoe print would be.
What does this mean? Did humans walk the earth millions of years before Scientist believed that did? Did humans walk with the Dinosaurs?
In cave painting in Mexico, there are animals that look a lot like dinosaurs. In the same area Clay figures have been found that also have a striking resemblance to beast that walked the earth Millions of years before Humans. Does this prove that Humans have been here for 100's of millions of years? Some would say yes it does, and other would claim them as hoaxes.
If they are real then the history of human kind as we know it will need to be re-written.
Author: 29561 Category
Discussion) Created3/23/2001 12:39:00 PM) Viewed (3317 times) Humans are currently thought to have emerged between 1 and 2 million years ago, but recent findings may prove that man is much older then that.
What may be the oldest fossil footprint yet found was discovered in June of 1968 by William J. Meister, an amateur fossil collector. This print is estimated to be around 300 to 600 MILLION years old! A sandaled shoe crushing a trilobite; is this proof that there were previous civilizations on earth, or visitors from another world? Could this foot print be from God? The sandal that crushed a living trilobite was 10 1/2 inches long and 3 1/2 inches wide; the heel is indented slightly more than the sole, as a human shoe print would be.
What does this mean? Did humans walk the earth millions of years before Scientist believed that did? Did humans walk with the Dinosaurs?
In cave painting in Mexico, there are animals that look a lot like dinosaurs. In the same area Clay figures have been found that also have a striking resemblance to beast that walked the earth Millions of years before Humans. Does this prove that Humans have been here for 100's of millions of years? Some would say yes it does, and other would claim them as hoaxes.
If they are real then the history of human kind as we know it will need to be re-written.
G
Guest
Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells
G
Guest
Cannabinoid receptors have been studied most in vertebrates, such as rats and mice. However, they are also found in invertebrates, such as leeches and mollusks.156 The evolutionary history of vertebrates and invertebrates diverged more than 500 million years ago, so cannabinoid receptors appear to have been conserved throughout evolution at least this long. This suggests that they serve an important and basic function in animal physiology. In general, cannabinoid receptor molecules are similar among different species.124 Thus, cannabinoid receptors likely fill many similar functions in a broad range of animals, including humans.
G
Guest
For any drug for which there is a receptor, the logical question is, "Why does this receptor exist?" The short answer is that there is probably an endogenous agonist (that is, a compound that is naturally produced in the brain) that acts on that receptor. The long answer begins with a search for such compounds in the area of the body that produce the receptors and ends with a determination of the natural function of those compounds. So far, the search has yielded several endogenous compounds that bind selectively to cannabinoid receptors. The best studied of them are anandamide37 and arachidonyl glycerol (2-AG).108 However, their physiological roles are not yet known.
Initially, the search for an endogenous cannabinoid was based on the premise that its chemical structure would be similar to that of THC; that was reasonable, in that it was really a search for another "key" that would fit into the cannabinoid receptor "keyhole," thereby activating the cellular message system. One of the intriguing discoveries in cannabinoid biology was how chemically different THC and anandamide are. A similar search for endogenous opioids (endorphins) also revealed that their chemical structure is very different from the plant-derived opioids, opium and morphine.
Further research has uncovered a variety of compounds with quite different chemical structures that can activate cannabinoid receptors It is not yet known exactly how anandamide and THC bind to cannabinoid receptors. Knowing this should permit more precise design of drugs that selectively activate the endogenous cannabinoid systems.
Initially, the search for an endogenous cannabinoid was based on the premise that its chemical structure would be similar to that of THC; that was reasonable, in that it was really a search for another "key" that would fit into the cannabinoid receptor "keyhole," thereby activating the cellular message system. One of the intriguing discoveries in cannabinoid biology was how chemically different THC and anandamide are. A similar search for endogenous opioids (endorphins) also revealed that their chemical structure is very different from the plant-derived opioids, opium and morphine.
Further research has uncovered a variety of compounds with quite different chemical structures that can activate cannabinoid receptors It is not yet known exactly how anandamide and THC bind to cannabinoid receptors. Knowing this should permit more precise design of drugs that selectively activate the endogenous cannabinoid systems.
brainthor,
If you really think humans were around 600 million years ago. or Cannabis plants for that matter, then it is a waste of my time talking to you.
-SamS
If you really think humans were around 600 million years ago. or Cannabis plants for that matter, then it is a waste of my time talking to you.
-SamS
