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RECENT interesting findings
- Thread starter Sam_Skunkman
- Start date
The complex interactions between flowering behaviour and fibre quality in hemp
https://sci-hub.tw/10.3389/fpls.2019.00614
Hemp, Cannabis sativa L., is a sustainable multipurpose fibre crop with high nutrient and water use efficiency and with biomass of excellent quality for textile fibres and construction materials. The yield and quality of hemp biomass are largely determined by the genetic background of the hemp cultivar but are also strongly affected by environmental factors, such as temperature and photoperiod. Hemp is a facultative short-day plant, characterized by a strong adaptation to photoperiod and a great influence of environmental factors on important agronomic traits such as “flowering-time” and “sex determination”. This sensitivity of hemp can cause a considerable degree of heterogeneity, leading to unforeseen yield reductions. Fibre quality for instance is influenced by the developmental stage of hemp at harvest. Also, male and female plants are differing in stature and produce fibres with different properties and quality. Next to these causes, there is evidence for specific genotypic variation in fibre quality among hemp accessions. Before improved hemp cultivars can be developed, with specific flowering-times and fibre qualities, and adapted to different geographical regions, a better understanding of the molecular mechanisms controlling important phenological traits such as “flowering-time” and “sex
determination” in relation to fibre quality in hemp is required. It is well known that genetic factors play a major role in the outcome of both phenological traits but, the major molecularfactors involved in this mechanism are not characterized in hemp. Genome sequences and transcriptome data are available but their analysis mainly focussed on the cannabinoid pathway for medical purposes. Herein, we review the current knowledge of phenotypic- and genetic data vailable for “flowering-time”, “sex determination” and “fibre quality” in short-day and dioecious crops, respectively, and compare them with the situation in hemp. A picture emerges for several
controlling key genes, for which natural genetic variation may lead to desired flowering behaviour, including examples of pleiotropic effects on yield quality and on carbon partitioning. Finally we discuss the prospects for using this knowledge for the molecular breeding of this sustainable crop via a candidate gene approach.
And this one:
Enabling the Next Generation Medicinal Breeding: Understanding Terpene Chemotypes in Cannabis
https://www.labtube.tv/video/enabli...=163821536.1.1555372800137&__hsfp=3733277192#
Both are very interesting...
As was the one posted by Azaghal a few posts ago
"Gene Networks Underlying Cannabinoid and Terpenoid Accumulation in Cannabis "
Glandular trichomes are specialized anatomical structures that accumulate secretions with important biological roles in plant–environment interactions. These secretions also have commercial uses in the flavor, fragrance, and pharmaceutical industries. The capitate-stalked glandular trichomes of Cannabis sativa (cannabis), situated on the surfaces of the bracts of the female flowers, are the primary site for the biosynthesis and storage of resins rich in cannabinoids and terpenoids. In this study, we profiled nine commercial cannabis strains with purportedly different attributes, such as taste, color, smell and genetic origin. Glandular trichomes were isolated from each of these strains and cell type-specific transcriptome data sets were acquired. Cannabinoids and terpenoids were quantified in flower buds. Statistical analyses indicated that these data sets enable the high-resolution differentiation of strains by providing complementary information. Integrative analyses revealed a coexpression network of genes involved in the biosynthesis of both cannabinoids and terpenoids from importedprecursors. Terpene synthase genes involved in the biosynthesis of the major mono- and sesquiterpenes routinely assayed by cannabis testing laboratories were identified and
functionally evaluated. In addition to cloning variants of previously characterized genes, specifically CsTPS14CT ((-)-limonene synthase) and CsTPS15CT (β-myrcene synthase) wefunctionally evaluated genes that encode enzymes with activities not previously described incannabis, namely CsTPS18VF and CsTPS19BL (nerolidol/linalool synthases); CsTPS16CC (germacrene B synthase); and CsTPS20CT (hedycaryol synthase). This study lays the groundwork for developing a better understanding of the complex chemistry and biochemistry underlying resin accumulation across commercial cannabis strains.
https://www.plantphysiol.org/content/plantphysiol/early/2019/05/28/pp.18.01506.full.pdf
-SamS
https://sci-hub.tw/10.3389/fpls.2019.00614
Hemp, Cannabis sativa L., is a sustainable multipurpose fibre crop with high nutrient and water use efficiency and with biomass of excellent quality for textile fibres and construction materials. The yield and quality of hemp biomass are largely determined by the genetic background of the hemp cultivar but are also strongly affected by environmental factors, such as temperature and photoperiod. Hemp is a facultative short-day plant, characterized by a strong adaptation to photoperiod and a great influence of environmental factors on important agronomic traits such as “flowering-time” and “sex determination”. This sensitivity of hemp can cause a considerable degree of heterogeneity, leading to unforeseen yield reductions. Fibre quality for instance is influenced by the developmental stage of hemp at harvest. Also, male and female plants are differing in stature and produce fibres with different properties and quality. Next to these causes, there is evidence for specific genotypic variation in fibre quality among hemp accessions. Before improved hemp cultivars can be developed, with specific flowering-times and fibre qualities, and adapted to different geographical regions, a better understanding of the molecular mechanisms controlling important phenological traits such as “flowering-time” and “sex
determination” in relation to fibre quality in hemp is required. It is well known that genetic factors play a major role in the outcome of both phenological traits but, the major molecularfactors involved in this mechanism are not characterized in hemp. Genome sequences and transcriptome data are available but their analysis mainly focussed on the cannabinoid pathway for medical purposes. Herein, we review the current knowledge of phenotypic- and genetic data vailable for “flowering-time”, “sex determination” and “fibre quality” in short-day and dioecious crops, respectively, and compare them with the situation in hemp. A picture emerges for several
controlling key genes, for which natural genetic variation may lead to desired flowering behaviour, including examples of pleiotropic effects on yield quality and on carbon partitioning. Finally we discuss the prospects for using this knowledge for the molecular breeding of this sustainable crop via a candidate gene approach.
And this one:
Enabling the Next Generation Medicinal Breeding: Understanding Terpene Chemotypes in Cannabis
https://www.labtube.tv/video/enabli...=163821536.1.1555372800137&__hsfp=3733277192#
Both are very interesting...
As was the one posted by Azaghal a few posts ago
"Gene Networks Underlying Cannabinoid and Terpenoid Accumulation in Cannabis "
Glandular trichomes are specialized anatomical structures that accumulate secretions with important biological roles in plant–environment interactions. These secretions also have commercial uses in the flavor, fragrance, and pharmaceutical industries. The capitate-stalked glandular trichomes of Cannabis sativa (cannabis), situated on the surfaces of the bracts of the female flowers, are the primary site for the biosynthesis and storage of resins rich in cannabinoids and terpenoids. In this study, we profiled nine commercial cannabis strains with purportedly different attributes, such as taste, color, smell and genetic origin. Glandular trichomes were isolated from each of these strains and cell type-specific transcriptome data sets were acquired. Cannabinoids and terpenoids were quantified in flower buds. Statistical analyses indicated that these data sets enable the high-resolution differentiation of strains by providing complementary information. Integrative analyses revealed a coexpression network of genes involved in the biosynthesis of both cannabinoids and terpenoids from importedprecursors. Terpene synthase genes involved in the biosynthesis of the major mono- and sesquiterpenes routinely assayed by cannabis testing laboratories were identified and
functionally evaluated. In addition to cloning variants of previously characterized genes, specifically CsTPS14CT ((-)-limonene synthase) and CsTPS15CT (β-myrcene synthase) wefunctionally evaluated genes that encode enzymes with activities not previously described incannabis, namely CsTPS18VF and CsTPS19BL (nerolidol/linalool synthases); CsTPS16CC (germacrene B synthase); and CsTPS20CT (hedycaryol synthase). This study lays the groundwork for developing a better understanding of the complex chemistry and biochemistry underlying resin accumulation across commercial cannabis strains.
https://www.plantphysiol.org/content/plantphysiol/early/2019/05/28/pp.18.01506.full.pdf
-SamS
Last edited:
Functional expression and characterization of trichome-specific (-)-limonene synthase and (+)-a-pinene synthase from Cannabis sativa
Nils Günnewich,Jonathan E. Page, Tobias G. Köllner, Jörg Degenhardt, Toni M. Kutchana
Natural product communications · March 2007 Natural Product Communications Vol. 0 (0) 2006
Two recombinant, stereospecific monoterpene synthases, a (-)-limonene synthase (CsTPS1) and a (+)-α-pinene synthase (CsTPS2), encoded by Cannabis sativa L. cv. ‘Skunk’ trichome mRNA, have been isolated and characterized. Recombinant CsTPS1 shows a Km value at 6.8 μM and a Kcat at 8.2 x 10-2 s-1, the pH optimum was determined at pH 6.5, and a temperature optimum at 40°C. Recombinant CsTPS2 shows a Km values at 6.7 μM and a Kcat at 8.1 x 10-2 s-1, the pH optimum was determined at pH 7.0, and a temperature optimum at 30°C. Phylogenetic analysis showed that both CsTPSs group within the angiosperm family and belong to the Tpsb subgroup of monoterpene synthases. The enzymatic products (-)-limonene and (+)-α-pinene were detected as natural products in C. sativa trichomes.
(PDF) Functional expression and characterization of trichome-specific (-)-limonene synthase and (+)-a-pinene synthase from Cannabis sativa. Available from: https://www.researchgate.net/public...e_and_-a-pinene_synthase_from_Cannabis_sativa [accessed Jun 10 2019].
https://www.researchgate.net/profil...nd-a-pinene-synthase-from-Cannabis-sativa.pdf
New trends in cannabis potency in USA and Europe during the last
decade (2008–2017)
Suman Chandra · Mohamed M. Radwan · Chandrani G. Majumdar · James C. Church · Tom P. Freeman, Mahmoud A. ElSohly
European Archives of Psychiatry and Clinical Neuroscience
Doi:10.1007/s00406-019-00983-5
Cannabis Chemovar Nomenclature Misrepresents Chemical and Genetic Diversity; Survey of Variations in Chemical Profiles and Genetic Markers in Nevada Medical Cannabis Samples
Ulrich Reimann-Philipp, Mark Speck, Cindy Orser, Steve Johnson, Aaron Hilyard, Helen Turner, Alexander J. Stokes, and Andrea L. Small-Howard
Cannabis and Cannabinoid Research
Volume ?, Number ?, 2019
DOI: 10.1089/can.2018.0063
Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor.
Kimura T, Ohta T, Watanabe K, Yoshimura H, Yamamoto I.
Biol Pharm Bull. 1998 Mar;21(3):224-6.
https://www.jstage.jst.go.jp/article/bpb1993/21/3/21_3_224/_pdf
The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain
Ethan B. Russo
Frontiers in Plant Science 1 January 2019 | Volume 9 | Article 1969
doi: 10.3389/fpls.2018.01969
The topic of Ccannabis curries controversy in every sphere of influence, whether politics, pharmacology, applied therapeutics or even botanical taxonomy. Debate as to the speciation of Cannabis, or a lack thereof, has swirled for more than 250 years. Because all Cannabis types are eminently capable of cross-breeding to produce fertile progeny, it is unlikely that any clear winner will emerge between the “lumpers” vs. “splitters” in this taxonomical debate. This is compounded by the profusion of Cannabis varieties available through the black market and even the developing legal market. While labeled “strains” in common parlance, this term is acceptable with respect to bacteria and viruses, but not among Plantae. Given that such factors as plant height and leaflet width do not distinguish one Cannabis plant from another and similar difficulties in defining terms in Cannabis, the only reasonable solution is to characterize them by their biochemical/pharmacological characteristics. Thus, it is best to refer to cannabisCannabis types as chemical varieties, or “chemovars.” The current wave of excitement in cannabisCannabis commerce has translated into a flurry of research on alternative sources, particularly yeasts, and complex systems for laboratory production have emerged, but these presuppose that single compounds are a desirable goal. Rather, the case for cannabisCannabis synergy via the “entourage effect” is currently sufficiently strong as to suggest that one molecule is unlikely to match the therapeutic and even industrial potential of cannabisCannabis itself as a phytochemical factory. The astounding plasticity of the cannabisCannabis genome additionally obviates the need for genetic modification techniques.
Nils Günnewich,Jonathan E. Page, Tobias G. Köllner, Jörg Degenhardt, Toni M. Kutchana
Natural product communications · March 2007 Natural Product Communications Vol. 0 (0) 2006
Two recombinant, stereospecific monoterpene synthases, a (-)-limonene synthase (CsTPS1) and a (+)-α-pinene synthase (CsTPS2), encoded by Cannabis sativa L. cv. ‘Skunk’ trichome mRNA, have been isolated and characterized. Recombinant CsTPS1 shows a Km value at 6.8 μM and a Kcat at 8.2 x 10-2 s-1, the pH optimum was determined at pH 6.5, and a temperature optimum at 40°C. Recombinant CsTPS2 shows a Km values at 6.7 μM and a Kcat at 8.1 x 10-2 s-1, the pH optimum was determined at pH 7.0, and a temperature optimum at 30°C. Phylogenetic analysis showed that both CsTPSs group within the angiosperm family and belong to the Tpsb subgroup of monoterpene synthases. The enzymatic products (-)-limonene and (+)-α-pinene were detected as natural products in C. sativa trichomes.
(PDF) Functional expression and characterization of trichome-specific (-)-limonene synthase and (+)-a-pinene synthase from Cannabis sativa. Available from: https://www.researchgate.net/public...e_and_-a-pinene_synthase_from_Cannabis_sativa [accessed Jun 10 2019].
https://www.researchgate.net/profil...nd-a-pinene-synthase-from-Cannabis-sativa.pdf
New trends in cannabis potency in USA and Europe during the last
decade (2008–2017)
Suman Chandra · Mohamed M. Radwan · Chandrani G. Majumdar · James C. Church · Tom P. Freeman, Mahmoud A. ElSohly
European Archives of Psychiatry and Clinical Neuroscience
Doi:10.1007/s00406-019-00983-5
Cannabis Chemovar Nomenclature Misrepresents Chemical and Genetic Diversity; Survey of Variations in Chemical Profiles and Genetic Markers in Nevada Medical Cannabis Samples
Ulrich Reimann-Philipp, Mark Speck, Cindy Orser, Steve Johnson, Aaron Hilyard, Helen Turner, Alexander J. Stokes, and Andrea L. Small-Howard
Cannabis and Cannabinoid Research
Volume ?, Number ?, 2019
DOI: 10.1089/can.2018.0063
Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor.
Kimura T, Ohta T, Watanabe K, Yoshimura H, Yamamoto I.
Biol Pharm Bull. 1998 Mar;21(3):224-6.
https://www.jstage.jst.go.jp/article/bpb1993/21/3/21_3_224/_pdf
The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain
Ethan B. Russo
Frontiers in Plant Science 1 January 2019 | Volume 9 | Article 1969
doi: 10.3389/fpls.2018.01969
The topic of Ccannabis curries controversy in every sphere of influence, whether politics, pharmacology, applied therapeutics or even botanical taxonomy. Debate as to the speciation of Cannabis, or a lack thereof, has swirled for more than 250 years. Because all Cannabis types are eminently capable of cross-breeding to produce fertile progeny, it is unlikely that any clear winner will emerge between the “lumpers” vs. “splitters” in this taxonomical debate. This is compounded by the profusion of Cannabis varieties available through the black market and even the developing legal market. While labeled “strains” in common parlance, this term is acceptable with respect to bacteria and viruses, but not among Plantae. Given that such factors as plant height and leaflet width do not distinguish one Cannabis plant from another and similar difficulties in defining terms in Cannabis, the only reasonable solution is to characterize them by their biochemical/pharmacological characteristics. Thus, it is best to refer to cannabisCannabis types as chemical varieties, or “chemovars.” The current wave of excitement in cannabisCannabis commerce has translated into a flurry of research on alternative sources, particularly yeasts, and complex systems for laboratory production have emerged, but these presuppose that single compounds are a desirable goal. Rather, the case for cannabisCannabis synergy via the “entourage effect” is currently sufficiently strong as to suggest that one molecule is unlikely to match the therapeutic and even industrial potential of cannabisCannabis itself as a phytochemical factory. The astounding plasticity of the cannabisCannabis genome additionally obviates the need for genetic modification techniques.
Last edited:
β-Cyclocitral is a conserved root growth regulator
Alexandra J. Dickinsona, Kevin Lehnera, Jianing Mid, Kun-Peng Jiad, Medhavinee Mijara, José Dinnenyc, Salim Al-Babilid, and Philip N. Benfeya
PNAS May 21, 2019 116 (21) 10563-10567; first published May 8, 2019
Doi: 10.1073/pnas.1821445116
Adverse Outcome Pathway of Developmental Neurotoxicity Resulting from Prenatal Exposures to Cannabis Contaminated with Organophosphate Pesticide Residues
Maxwell C. K. Leung, Marilyn H. Silva, Amanda J. Palumbo, Peter N. Lohstroh, Svetlana E. Koshlukova, Shelley B. DuTeaux
Reproductive Toxicology
Doi: 10.1016/j.reprotox.2019.01.004
Is Cannabis Testing Now for Growers Too?
Leo Bear-McGuinness
https://www.analyticalcannabis.com/articles/is-cannabis-testing-now-for-growers-too-311485
Advanced methods of plant disease detection. A review
Federico Martinelli, Riccardo Scalenghe, Salvatore Davino, Stefano Panno, Giuseppe Scuderi, Paolo Ruisi, Paolo Villa, Daniela Stroppiana, Mirco Boschetti, Luiz R. Goulart, et al.
Agronomy for Sustainable Development, Springer Verlag/EDP Sciences/INRA, 2015, 35 (1), pp.1-25.
Doi: 10.1007/s13593-014-0246-1
Molecular characterization, vector identification and sources of phytoplasmas associated with brinjal little leaf disease in India
Manish Kumar, Madhupriya, Govind Pratap Rao,
3 Biotech (2017) 7:7
DOI 10.1007/s13205-017-0616-x
PROGRESS IN EARLY SEX DETERMINATION OF CANNABIS PLANT BY DNA MARKERS
Conference Paper · November 2016 MENDELNET 2016, ; 731-735
Peter Mendel, Ajinkya Lalge, Tomáš Vyhnánek, Ladislav Havel, Václav Trojan, Petr Kalousek, Hugo Maassen
https://mendelnet.cz/pdfs/mnt/2016/01/130.pdf
Cryopreservation of Shoot Tips of Elite Cultivars of Cannabis sativa L. by Droplet Vitrification
Esther Uchendu, Hemant Lata, Suman Chandra, Ikhlas A. Khan, Mahmoud A. ElSohly
Med Cannabis Cannabinoids
Accepted: January 8, 2019
DOI: 10.1159/000496869
Genetic tools weed out misconceptions of strain reliability in Cannabis sativa: Implications for a budding industry
Anna L. Schwabe1 and Mitchell E. McGlaughlin
bioRxiv preprint
doi: http://dx.doi.org/10.1101/332320
Alexandra J. Dickinsona, Kevin Lehnera, Jianing Mid, Kun-Peng Jiad, Medhavinee Mijara, José Dinnenyc, Salim Al-Babilid, and Philip N. Benfeya
PNAS May 21, 2019 116 (21) 10563-10567; first published May 8, 2019
Doi: 10.1073/pnas.1821445116
Adverse Outcome Pathway of Developmental Neurotoxicity Resulting from Prenatal Exposures to Cannabis Contaminated with Organophosphate Pesticide Residues
Maxwell C. K. Leung, Marilyn H. Silva, Amanda J. Palumbo, Peter N. Lohstroh, Svetlana E. Koshlukova, Shelley B. DuTeaux
Reproductive Toxicology
Doi: 10.1016/j.reprotox.2019.01.004
Is Cannabis Testing Now for Growers Too?
Leo Bear-McGuinness
https://www.analyticalcannabis.com/articles/is-cannabis-testing-now-for-growers-too-311485
Advanced methods of plant disease detection. A review
Federico Martinelli, Riccardo Scalenghe, Salvatore Davino, Stefano Panno, Giuseppe Scuderi, Paolo Ruisi, Paolo Villa, Daniela Stroppiana, Mirco Boschetti, Luiz R. Goulart, et al.
Agronomy for Sustainable Development, Springer Verlag/EDP Sciences/INRA, 2015, 35 (1), pp.1-25.
Doi: 10.1007/s13593-014-0246-1
Molecular characterization, vector identification and sources of phytoplasmas associated with brinjal little leaf disease in India
Manish Kumar, Madhupriya, Govind Pratap Rao,
3 Biotech (2017) 7:7
DOI 10.1007/s13205-017-0616-x
PROGRESS IN EARLY SEX DETERMINATION OF CANNABIS PLANT BY DNA MARKERS
Conference Paper · November 2016 MENDELNET 2016, ; 731-735
Peter Mendel, Ajinkya Lalge, Tomáš Vyhnánek, Ladislav Havel, Václav Trojan, Petr Kalousek, Hugo Maassen
https://mendelnet.cz/pdfs/mnt/2016/01/130.pdf
Cryopreservation of Shoot Tips of Elite Cultivars of Cannabis sativa L. by Droplet Vitrification
Esther Uchendu, Hemant Lata, Suman Chandra, Ikhlas A. Khan, Mahmoud A. ElSohly
Med Cannabis Cannabinoids
Accepted: January 8, 2019
DOI: 10.1159/000496869
Genetic tools weed out misconceptions of strain reliability in Cannabis sativa: Implications for a budding industry
Anna L. Schwabe1 and Mitchell E. McGlaughlin
bioRxiv preprint
doi: http://dx.doi.org/10.1101/332320
Last edited:
Terpene synthases from Cannabis sativa
Judith K. Booth, Jonathan E. Page, Jorg Bohlmann
PLoS ONE 12(3): e0173911 2017
Doi: 10.1371/journal.pone.0173911
Yield and cannabinoids contents in different cannabis (Cannabis sativa L.) genotypes for medical use
Anežka Janatováa, Adéla Fraňkováb, Pavel Tlustošc, Karel Hamouza, Matěj Božikb,
Pavel Kloučekb,
Industrial Crops & Products 112 (2018) 363–367
Doi: 10.1016/j.indcrop.2017.12.006
Consumer perceptions of strain differences in Cannabis aroma.
Gilbert AN, DiVerdi JA (2018)
PLoS ONE 13(2): e0192247.
Doi: 10.1371/journal.pone.0192247
Judith K. Booth, Jonathan E. Page, Jorg Bohlmann
PLoS ONE 12(3): e0173911 2017
Doi: 10.1371/journal.pone.0173911
Yield and cannabinoids contents in different cannabis (Cannabis sativa L.) genotypes for medical use
Anežka Janatováa, Adéla Fraňkováb, Pavel Tlustošc, Karel Hamouza, Matěj Božikb,
Pavel Kloučekb,
Industrial Crops & Products 112 (2018) 363–367
Doi: 10.1016/j.indcrop.2017.12.006
Consumer perceptions of strain differences in Cannabis aroma.
Gilbert AN, DiVerdi JA (2018)
PLoS ONE 13(2): e0192247.
Doi: 10.1371/journal.pone.0192247
Last edited:
In silico discovery of terpenoid metabolism in Cannabis sativa
Luca*Massimino
06*Feb*2017,*F1000Res 6:107*
doi:*10.12688/f1000research.10778.1*
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482328/pdf/f1000research-6-11622.pdf
Structure determination and absolute configuration of cannabichromanone derivatives from high potency Cannabis sativa.
Ahmed SA, Ross SA, Slade D, Radwan MM, Khan IA, ElSohly MA
Tetrahedron Lett 49: 6050–6053 (2008a)
doi: 10.1016/j.tetlet.2008.07.178
Terpenes in Cannabis sativa – from plant genome to humans.
Booth JK, Bohlmann J (2019)
Plant Sci 284: 67-72
Doi: 10.1016/j.plantsci.2019.03.022
Cannabinoids and terpenes as chemotaxonomic markers in cannabis.
Elzinga S, Fischedick J, Podkolinski R, Raber JC (2015)
Nat Prod Chem Res 3: 2
https://www.researchgate.net/profil...n_Cannabis/links/55d0f9a908ae118c85c016aa.pdf
Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol.
Fellermeier M, Zenk MH (1998)
FEBS Lett 427: 283–285
https://www.sciencedirect.com/science/article/pii/S0014579398004505
Identification of terpenoid chemotypes among high (−)-trans-Δ9-tetrahydrocannabinol-producing Cannabis sativa L. cultivars.
Fischedick JT (2017)
Cannabis Cannabinoid Res 2: 34–47
https://www.researchgate.net/public...nabinol-Producing_Cannabis_sativa_L_Cultivars
Metabolic fingerprinting of Cannabis sativa L. cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes.
Fischedick JT, Hazekamp A, Erkelens T, Choi YH, Verpoorte R (2010)
Phytochemistry 71: 2058–2073
doi: 10.1016/j.phytochem.2010.10.001
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE (2012)
Proc Natl Acad Sci USA 109: 12811–12816.
doi: 10.1073/pnas.1200330109.
Luca*Massimino
06*Feb*2017,*F1000Res 6:107*
doi:*10.12688/f1000research.10778.1*
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482328/pdf/f1000research-6-11622.pdf
Structure determination and absolute configuration of cannabichromanone derivatives from high potency Cannabis sativa.
Ahmed SA, Ross SA, Slade D, Radwan MM, Khan IA, ElSohly MA
Tetrahedron Lett 49: 6050–6053 (2008a)
doi: 10.1016/j.tetlet.2008.07.178
Terpenes in Cannabis sativa – from plant genome to humans.
Booth JK, Bohlmann J (2019)
Plant Sci 284: 67-72
Doi: 10.1016/j.plantsci.2019.03.022
Cannabinoids and terpenes as chemotaxonomic markers in cannabis.
Elzinga S, Fischedick J, Podkolinski R, Raber JC (2015)
Nat Prod Chem Res 3: 2
https://www.researchgate.net/profil...n_Cannabis/links/55d0f9a908ae118c85c016aa.pdf
Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the precursor of tetrahydrocannabinol.
Fellermeier M, Zenk MH (1998)
FEBS Lett 427: 283–285
https://www.sciencedirect.com/science/article/pii/S0014579398004505
Identification of terpenoid chemotypes among high (−)-trans-Δ9-tetrahydrocannabinol-producing Cannabis sativa L. cultivars.
Fischedick JT (2017)
Cannabis Cannabinoid Res 2: 34–47
https://www.researchgate.net/public...nabinol-Producing_Cannabis_sativa_L_Cultivars
Metabolic fingerprinting of Cannabis sativa L. cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes.
Fischedick JT, Hazekamp A, Erkelens T, Choi YH, Verpoorte R (2010)
Phytochemistry 71: 2058–2073
doi: 10.1016/j.phytochem.2010.10.001
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE (2012)
Proc Natl Acad Sci USA 109: 12811–12816.
doi: 10.1073/pnas.1200330109.
Last edited:
Cannabis - from cultivar to chemovar: Towards a better definition of Cannabis potency.
Hazekamp A, Fischedick JT (2012)
Drug Test Anal 4: 660–667
https://bedrocan.com/wp-content/uploads/2012-cannabis-from-cultivar-to-chemovar_hazekamp.pdf
Cannabis: from cultivar to chemovar II-a metabolomics approach to Cannabis
classification.
Hazekamp A, Tejkalová K, Papadimitriou S (2016)
Cannabis Cannabinoid Res 1: 202–215
https://pdfs.semanticscholar.org/01...28.885678155.1560054937-1158681808.1560054937
DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in
"drug-type" and "fiber-type" Cannabis sativa L.
Kojoma M, Seki H, Yoshida S, Muranaka T (2006)
Forensic Sci Int 159: 132–140
DOI: 10.1016/j.forsciint.2005.07.005
A physical and genetic map of Cannabis sativa identifies extensive rearrangement at the THC/CBD acid synthase locus.
Laverty KU, Stout JM, Sullivan MJ, Shah H, Gill N, Bolbrook L, Deikus G, Sebra R, Hughes TR, Page JE, van Bakel H (2018)
Genome Res, in press,
doi: 10.1101/gr.242594.118
Pharmacological foundations of Cannabis chemovars.
Lewis MA, Russo EB, Smith KM (2018)
Planta Med 84: 225–233
doi: 10.1055/s-0043-122240
The essential oil of Cannabis sativa.
Malingre T, Hendriks H, Batterman S, Bos R, Visser J (1975)
Planta Med 28: 56–61
DOI: 10.1055/s-0028-1097829
Identification of candidate genes affecting Δ9-tetrahydrocannabinol biosynthesis in Cannabis sativa.
Marks MD, Tian L, Wenger JP, Omburo SN, Soto-Fuentes W, He J, Gang DR, Weiblen GD, Dixon RA (2009)
J Exp Bot 60: 3715–3726
doi: 10.1093/jxb/erp210
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736886/pdf/erp210.pdf
Terpenoid chemoprofiles distinguish drug-type Cannabis sativa L. cultivars in Nevada.
Orser C, Johnson S, Speck M, Hilyard A, Afia I (2018)
Nat Prod Chem Res 6: 304
https://www.researchgate.net/public...ug-type_Cannabis_sativa_L_Cultivars_in_Nevada
Differentiation between fiber and drug types of hemp (Cannabis sativa L.) from a collection of wild and domesticated accessions.
Piluzza G, Delogu G, Cabras A, Marceddu S, Bullitta S (2013)
Genet Res Crop Evol 60: 2331–2342
https://www.researchgate.net/public...ollection_of_wild_and_domesticated_accessions
Assessing Genetic Diversity in Cannabis sativa Using Molecular Approaches.
Punja ZK, Rodriguez G, Chen S (2017)
In S Chandra, H Lata, MA ElSohly, eds, Cannabis sativa L. - Botany and Biotechnology. Springer International Publishing, Cham, pp 395–418
DOI :10.1007/978-3-319-54564-6_19
Characterizing the smell of marijuana by odor impact of volatile compounds: an application of simultaneous chemical and sensory analysis.
Rice S, Koziel JA (2015)
PloS One 10: e0144160
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144160&type=printable
Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
Russo EB (2011)
Br J Pharmacol 163:1344–1364
doi: 10.1111/j.1476-5381.2011.01238.x
Evaluation of cannabinoid and terpenoid content: Cannabis flower compared to supercritical CO2 concentrate.
Sexton M, Shelton K, Haley P, West M (2018)
Planta Med 84: 234–241
doi: 10.1055/s-0043-119361
Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes.
Sirikantaramas S, Taura F, Tanaka Y, Ishikawa Y, Morimoto S, Shoyama Y (2005)
Plant Cell Physiol 46: 1578–1582
https://www.researchgate.net/public...the_Storage_Cavity_of_the_Glandular_Trichomes
Phytochemical and genetic analyses of ancient cannabis from Central Asia.
Russo EB, Jiang H-E, Li X, Sutton A, Carboni A, del Bianco F, Mandolino G, Potter DJ, Zhao Y-X, Bera S, et al (2008)
J Exp Bot 59: 4171–4182
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639026/pdf/ern260.pdf
Evolution and classification of Cannabis sativa (marijuana, hemp) in relation to human utilization.
Small E (2015)
Bot Rev 81: 189–294
DOI: 10.1007/s12229-015-9157-3
The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes.
Stout JM, Boubakir Z, Ambrose SJ, Purves RW, Page JE (2012
Plant J 71: 353–365
doi: 10.1111/j.1365-313X.2012.04949.x.
Phytocannabinoids in Cannabis sativa: Recent studies on biosynthetic enzymes.
Taura F, Sirikantaramas S, Shoyama Y, Shoyama Y, Morimoto S (2007)
Chem Biodiv 4: 1649–1663
DOI: 10.1002/cbdv.200790145
Differentiation of marijuana headspace volatiles from other plants and hemp products using capillary microextraction of volatiles (CMV) coupled to gas-chromatography–mass spectrometry (GC–MS).
Wiebelhaus N, Kreitals NM, Almirall JR (2016)
Forensic Chem 2: 1–8
doi: 10.1016/j.forc.2016.08.004
Hazekamp A, Fischedick JT (2012)
Drug Test Anal 4: 660–667
https://bedrocan.com/wp-content/uploads/2012-cannabis-from-cultivar-to-chemovar_hazekamp.pdf
Cannabis: from cultivar to chemovar II-a metabolomics approach to Cannabis
classification.
Hazekamp A, Tejkalová K, Papadimitriou S (2016)
Cannabis Cannabinoid Res 1: 202–215
https://pdfs.semanticscholar.org/01...28.885678155.1560054937-1158681808.1560054937
DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in
"drug-type" and "fiber-type" Cannabis sativa L.
Kojoma M, Seki H, Yoshida S, Muranaka T (2006)
Forensic Sci Int 159: 132–140
DOI: 10.1016/j.forsciint.2005.07.005
A physical and genetic map of Cannabis sativa identifies extensive rearrangement at the THC/CBD acid synthase locus.
Laverty KU, Stout JM, Sullivan MJ, Shah H, Gill N, Bolbrook L, Deikus G, Sebra R, Hughes TR, Page JE, van Bakel H (2018)
Genome Res, in press,
doi: 10.1101/gr.242594.118
Pharmacological foundations of Cannabis chemovars.
Lewis MA, Russo EB, Smith KM (2018)
Planta Med 84: 225–233
doi: 10.1055/s-0043-122240
The essential oil of Cannabis sativa.
Malingre T, Hendriks H, Batterman S, Bos R, Visser J (1975)
Planta Med 28: 56–61
DOI: 10.1055/s-0028-1097829
Identification of candidate genes affecting Δ9-tetrahydrocannabinol biosynthesis in Cannabis sativa.
Marks MD, Tian L, Wenger JP, Omburo SN, Soto-Fuentes W, He J, Gang DR, Weiblen GD, Dixon RA (2009)
J Exp Bot 60: 3715–3726
doi: 10.1093/jxb/erp210
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736886/pdf/erp210.pdf
Terpenoid chemoprofiles distinguish drug-type Cannabis sativa L. cultivars in Nevada.
Orser C, Johnson S, Speck M, Hilyard A, Afia I (2018)
Nat Prod Chem Res 6: 304
https://www.researchgate.net/public...ug-type_Cannabis_sativa_L_Cultivars_in_Nevada
Differentiation between fiber and drug types of hemp (Cannabis sativa L.) from a collection of wild and domesticated accessions.
Piluzza G, Delogu G, Cabras A, Marceddu S, Bullitta S (2013)
Genet Res Crop Evol 60: 2331–2342
https://www.researchgate.net/public...ollection_of_wild_and_domesticated_accessions
Assessing Genetic Diversity in Cannabis sativa Using Molecular Approaches.
Punja ZK, Rodriguez G, Chen S (2017)
In S Chandra, H Lata, MA ElSohly, eds, Cannabis sativa L. - Botany and Biotechnology. Springer International Publishing, Cham, pp 395–418
DOI :10.1007/978-3-319-54564-6_19
Characterizing the smell of marijuana by odor impact of volatile compounds: an application of simultaneous chemical and sensory analysis.
Rice S, Koziel JA (2015)
PloS One 10: e0144160
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144160&type=printable
Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.
Russo EB (2011)
Br J Pharmacol 163:1344–1364
doi: 10.1111/j.1476-5381.2011.01238.x
Evaluation of cannabinoid and terpenoid content: Cannabis flower compared to supercritical CO2 concentrate.
Sexton M, Shelton K, Haley P, West M (2018)
Planta Med 84: 234–241
doi: 10.1055/s-0043-119361
Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomes.
Sirikantaramas S, Taura F, Tanaka Y, Ishikawa Y, Morimoto S, Shoyama Y (2005)
Plant Cell Physiol 46: 1578–1582
https://www.researchgate.net/public...the_Storage_Cavity_of_the_Glandular_Trichomes
Phytochemical and genetic analyses of ancient cannabis from Central Asia.
Russo EB, Jiang H-E, Li X, Sutton A, Carboni A, del Bianco F, Mandolino G, Potter DJ, Zhao Y-X, Bera S, et al (2008)
J Exp Bot 59: 4171–4182
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639026/pdf/ern260.pdf
Evolution and classification of Cannabis sativa (marijuana, hemp) in relation to human utilization.
Small E (2015)
Bot Rev 81: 189–294
DOI: 10.1007/s12229-015-9157-3
The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes.
Stout JM, Boubakir Z, Ambrose SJ, Purves RW, Page JE (2012
Plant J 71: 353–365
doi: 10.1111/j.1365-313X.2012.04949.x.
Phytocannabinoids in Cannabis sativa: Recent studies on biosynthetic enzymes.
Taura F, Sirikantaramas S, Shoyama Y, Shoyama Y, Morimoto S (2007)
Chem Biodiv 4: 1649–1663
DOI: 10.1002/cbdv.200790145
Differentiation of marijuana headspace volatiles from other plants and hemp products using capillary microextraction of volatiles (CMV) coupled to gas-chromatography–mass spectrometry (GC–MS).
Wiebelhaus N, Kreitals NM, Almirall JR (2016)
Forensic Chem 2: 1–8
doi: 10.1016/j.forc.2016.08.004
Last edited:
Douglas.Curtis
Autistic Diplomat in Training
My head already hurts, but keep it coming. 
Greatly appreciated!
Greatly appreciated! 
Good stuff.
Glad to know the subject has produced the required studies
to back up the work all us knuckleheads are doing in the trenches.
lol
And thanks Sam for the links, we all have some reading to catch up on.
Glad to know the subject has produced the required studies
to back up the work all us knuckleheads are doing in the trenches.
lol
And thanks Sam for the links, we all have some reading to catch up on.
If I did not post a link for the paper try the doi number just open https://sci-hub.tw/ paste in the doi and you can download the full paper.
If I posted https//www._____________ I have been informed just remove the s from https, I tried to do it but my computer keeps adding them back no matter what I do.
If I posted https//www._____________ I have been informed just remove the s from https, I tried to do it but my computer keeps adding them back no matter what I do.
Last edited:
A few are older but they are interesting...
-SamS
Latitudinal Adaptation and Genetic Insights Into the Origins of Cannabis sativa L.
Qingying Zhang, Xuan Chen, Hongyan Guo, Luisa M. Trindade, Elma M. J. Salentijn, Rong Guo, Mengbi Guo, Yanping Xu and Ming Yang
Frontiers In Plant Science December 2018 | Volume 9 | Article 1876
doi: 10.3389/fpls.2018.01876
https://www.frontiersin.org/articles/10.3389/fpls.2018.01876/full
Absence of entourage: Terpenoids commonly found in Cannabis sativa do not modulate the functional activity of Δ9-THC at human CB1 and CB2 receptors
Marina Santiago, Shivani Sachdev, Jonathon C Arnold, Iain S McGregor, and Mark Connor
Doi: 10.1101/569079
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast
Xiaozhou Luo, Michael A. Reiter, Leo d’Espaux, Jeff Wong, Charles M. Denby, Anna Lechner, Yunfeng Zhang, Adrian T. Grzybowski, Simon Harth, Weiyin Lin, Hyunsu Lee, Changhua Yu, John Shin, Kai Deng, Veronica T. Benites, George Wang, Edward E. K. Baidoo, Yan Chen, Ishaan Dev, Christopher J. Petzold & Jay D. Keasling1
Nature Letter
doi: 10.1038/s41586-019-0978-9
A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC-and CBD-acids
Marianne Hädenera, Sina Vietenb, Wolfgang Weinmanna, Hellmut Mahler
Forensic Science International 2018
doi:10.1016/j.forsciint.2018.12.021
Photosynthetic response of Cannabis sativa L. to variations in photosynthetic photon flux densities, temperature and CO2 conditions
Suman Chandra, Hemant Lata, Ikhlas A. Khan, and Mahmoud A. Elsohly
Physiol. Mol. Biol. Plants, 14(4)–October, 2008
doi: 10.1007/s12298-008-0027-x
A review of Cannabis sativa-based insecticides, Miticides, and repellents
John McPartland, Zahra Sheikh
Journal of Entomology and Zoology Studies 2018; 6(6): 1288-1299
https://www.researchgate.net/public...a_based_insecticides_Miticides_and_repellents
Chemical fingerprinting of single glandular trichomes of Cannabis sativa by Coherent anti-Stokes Raman scattering (CARS) microscopy
Paul Ebersbach, Felix Stehle, Oliver Kayser and Erik Freier
BMC Plant Biology (2018) 18:275
Doi: 1186/s12870-018-1481-4
Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study
Gokhan Zengin, Luigi Menghini, Antonella Di Sotto, Romina Mancinelli, Francesca Sisto, Simone Carradori, Stefania Cesa, Caterina Fraschetti, Antonello Filippi, Letizia Angiolella, Marcello Locatelli, Luisa Mannina, Cinzia Ingallina, Valentina Puca, Marianna D’Antonio and Rossella Grande
Molecules 2018, 23, 3266;
doi:10.3390/molecules23123266
FAAH inhibition for treatment of problematic cannabis use
Tony P George
Lancet Psychiatry Published online December 6, 2018
doi: 10.1016/S2215-0366(18)30462-0
Experimental Endozoochory of Cannabis sativa Achenes
John M. McPartland, Steve G. Naraine
Med Cannabis Cannabinoids Published online: October 8, 2018
DOI: 10.1159/000492971
Cannabinoid Receptors Are Absent in Insects
JOHN MCPARTLAND, VINCENZO DI MARZO, LUCIANO DE PETROCELLIS, LISON MERCER, AND MICHELLE GLASS
THE JOURNAL OF COMPARATIVE NEUROLOGY 436:423–429 (2001)
doi: 10.1002/cne.1078
The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act through 5-HT1A receptors to produce anti-psychotic effects
Maria Grazia Cascio1, Erica Zamberletti, Pietro Marini, Daniela Parolaro2,3 and Roger G. Pertwee
Br J Pharmacol. 2015 Mar;172(5):1305-18.
doi: 10.1111/bph.13000.
A complete Cannabis chromosome assembly and adaptive admixture for elevated cannabidiol (CBD) content
Christopher J. Grassa, Jonathan P. Wenger, Clemon Dabney, Shane G. Poplawski, S. Timothy Motley, Todd 5 P. Michael, C.J. Schwartz, George D. Weiblen
doi: 10.1101/458083
Phytocannabinoids: a unified critical inventory
Lum´ır Ondˇrej Hanuˇs, Stefan Martin Meyer, Eduardo Munoz, Orazio Taglialatela-Scafatid and Giovanni Appendino
Natural Product Reports 2016 The Royal Society of Chemistry
DOI: 10.1039/c6np00074f
Developmental Plasticity of the Major Alkyl Cannabinoid
Chemotypes in a Diverse Cannabis Genetic Resource Collection
Matthew T. Welling, Lei Liu1, Carolyn A. Raymond, Omid Ansari, and
Graham J. King
Frontiers in Plant Science | 1 October 2018 | Volume 9 | Article 1510
doi: 10.3389/fpls.2018.01510
Chemometric Analysis of Cannabinoids: Chemotaxonomy and Domestication Syndrome
E. M. Mudge, S. J. Murch & P. N. Brown
Nature Scientific Reports | (2018) 8:13090
DOI:10.1038/s41598-018-31120-2
Cannabichromene
Federica Pollastroa, Diego Caprioglioa, Danilo Del Pretea, Federica Rogatia, Alberto Minassia, Orazio Taglialatela-Scafatib, Eduardo Munozc and Giovanni Appendinoa
NCP Natural Products Communications 2018 Vol. 13, No. 9, 1189-1194
https://www.researchgate.net/publication/327801252_Cannabichromene
New developments in fiber hemp (Cannabis sativa L.) breeding
Elma M.J. Salentijna, Qingying Zhangb, Stefano Amaduccic,Ming Yangb, Luisa M. Trindadea,
Industrial Crops and Products Vol. 68, June 2015, pages 32-41
doi: 10.1016/j.indcrop.2014.08.011
Development of the Industrial Chain for the Production of Cannabigerol (CBG): from Plant to Pure Compound
Xavier Nadal Roura, PhD
Manager Extraction R&D Department, Phytoplant Research S.L.
Presented at CANN 10 Tel Aviv, Israel June 5 2017
https://www.phytoplantresearch.com/...-Cannabigerol-from-Plant-to-Pure-Compound.pdf
-SamS
Latitudinal Adaptation and Genetic Insights Into the Origins of Cannabis sativa L.
Qingying Zhang, Xuan Chen, Hongyan Guo, Luisa M. Trindade, Elma M. J. Salentijn, Rong Guo, Mengbi Guo, Yanping Xu and Ming Yang
Frontiers In Plant Science December 2018 | Volume 9 | Article 1876
doi: 10.3389/fpls.2018.01876
https://www.frontiersin.org/articles/10.3389/fpls.2018.01876/full
Absence of entourage: Terpenoids commonly found in Cannabis sativa do not modulate the functional activity of Δ9-THC at human CB1 and CB2 receptors
Marina Santiago, Shivani Sachdev, Jonathon C Arnold, Iain S McGregor, and Mark Connor
Doi: 10.1101/569079
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast
Xiaozhou Luo, Michael A. Reiter, Leo d’Espaux, Jeff Wong, Charles M. Denby, Anna Lechner, Yunfeng Zhang, Adrian T. Grzybowski, Simon Harth, Weiyin Lin, Hyunsu Lee, Changhua Yu, John Shin, Kai Deng, Veronica T. Benites, George Wang, Edward E. K. Baidoo, Yan Chen, Ishaan Dev, Christopher J. Petzold & Jay D. Keasling1
Nature Letter
doi: 10.1038/s41586-019-0978-9
A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC-and CBD-acids
Marianne Hädenera, Sina Vietenb, Wolfgang Weinmanna, Hellmut Mahler
Forensic Science International 2018
doi:10.1016/j.forsciint.2018.12.021
Photosynthetic response of Cannabis sativa L. to variations in photosynthetic photon flux densities, temperature and CO2 conditions
Suman Chandra, Hemant Lata, Ikhlas A. Khan, and Mahmoud A. Elsohly
Physiol. Mol. Biol. Plants, 14(4)–October, 2008
doi: 10.1007/s12298-008-0027-x
A review of Cannabis sativa-based insecticides, Miticides, and repellents
John McPartland, Zahra Sheikh
Journal of Entomology and Zoology Studies 2018; 6(6): 1288-1299
https://www.researchgate.net/public...a_based_insecticides_Miticides_and_repellents
Chemical fingerprinting of single glandular trichomes of Cannabis sativa by Coherent anti-Stokes Raman scattering (CARS) microscopy
Paul Ebersbach, Felix Stehle, Oliver Kayser and Erik Freier
BMC Plant Biology (2018) 18:275
Doi: 1186/s12870-018-1481-4
Chromatographic Analyses, In Vitro Biological Activities, and Cytotoxicity of Cannabis sativa L. Essential Oil: A Multidisciplinary Study
Gokhan Zengin, Luigi Menghini, Antonella Di Sotto, Romina Mancinelli, Francesca Sisto, Simone Carradori, Stefania Cesa, Caterina Fraschetti, Antonello Filippi, Letizia Angiolella, Marcello Locatelli, Luisa Mannina, Cinzia Ingallina, Valentina Puca, Marianna D’Antonio and Rossella Grande
Molecules 2018, 23, 3266;
doi:10.3390/molecules23123266
FAAH inhibition for treatment of problematic cannabis use
Tony P George
Lancet Psychiatry Published online December 6, 2018
doi: 10.1016/S2215-0366(18)30462-0
Experimental Endozoochory of Cannabis sativa Achenes
John M. McPartland, Steve G. Naraine
Med Cannabis Cannabinoids Published online: October 8, 2018
DOI: 10.1159/000492971
Cannabinoid Receptors Are Absent in Insects
JOHN MCPARTLAND, VINCENZO DI MARZO, LUCIANO DE PETROCELLIS, LISON MERCER, AND MICHELLE GLASS
THE JOURNAL OF COMPARATIVE NEUROLOGY 436:423–429 (2001)
doi: 10.1002/cne.1078
The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act through 5-HT1A receptors to produce anti-psychotic effects
Maria Grazia Cascio1, Erica Zamberletti, Pietro Marini, Daniela Parolaro2,3 and Roger G. Pertwee
Br J Pharmacol. 2015 Mar;172(5):1305-18.
doi: 10.1111/bph.13000.
A complete Cannabis chromosome assembly and adaptive admixture for elevated cannabidiol (CBD) content
Christopher J. Grassa, Jonathan P. Wenger, Clemon Dabney, Shane G. Poplawski, S. Timothy Motley, Todd 5 P. Michael, C.J. Schwartz, George D. Weiblen
doi: 10.1101/458083
Phytocannabinoids: a unified critical inventory
Lum´ır Ondˇrej Hanuˇs, Stefan Martin Meyer, Eduardo Munoz, Orazio Taglialatela-Scafatid and Giovanni Appendino
Natural Product Reports 2016 The Royal Society of Chemistry
DOI: 10.1039/c6np00074f
Developmental Plasticity of the Major Alkyl Cannabinoid
Chemotypes in a Diverse Cannabis Genetic Resource Collection
Matthew T. Welling, Lei Liu1, Carolyn A. Raymond, Omid Ansari, and
Graham J. King
Frontiers in Plant Science | 1 October 2018 | Volume 9 | Article 1510
doi: 10.3389/fpls.2018.01510
Chemometric Analysis of Cannabinoids: Chemotaxonomy and Domestication Syndrome
E. M. Mudge, S. J. Murch & P. N. Brown
Nature Scientific Reports | (2018) 8:13090
DOI:10.1038/s41598-018-31120-2
Cannabichromene
Federica Pollastroa, Diego Caprioglioa, Danilo Del Pretea, Federica Rogatia, Alberto Minassia, Orazio Taglialatela-Scafatib, Eduardo Munozc and Giovanni Appendinoa
NCP Natural Products Communications 2018 Vol. 13, No. 9, 1189-1194
https://www.researchgate.net/publication/327801252_Cannabichromene
New developments in fiber hemp (Cannabis sativa L.) breeding
Elma M.J. Salentijna, Qingying Zhangb, Stefano Amaduccic,Ming Yangb, Luisa M. Trindadea,
Industrial Crops and Products Vol. 68, June 2015, pages 32-41
doi: 10.1016/j.indcrop.2014.08.011
Development of the Industrial Chain for the Production of Cannabigerol (CBG): from Plant to Pure Compound
Xavier Nadal Roura, PhD
Manager Extraction R&D Department, Phytoplant Research S.L.
Presented at CANN 10 Tel Aviv, Israel June 5 2017
https://www.phytoplantresearch.com/...-Cannabigerol-from-Plant-to-Pure-Compound.pdf
Last edited:
In the last few days I added 67 more articles if any are duplicates please let me know so I can fix that.
I hope folks can use these, the pace of Cannabis research is speeding up every year, if anyone has any article that is new and might be interesting to IC readers post it or send it to me via PM and I will post it in this thread.
-SamS
I hope folks can use these, the pace of Cannabis research is speeding up every year, if anyone has any article that is new and might be interesting to IC readers post it or send it to me via PM and I will post it in this thread.
-SamS
Evolution and Classification of Cannabis sativa (Marijuana, Hemp) in Relation to Human Utilization
Ernest Small
The Botanical Review
2015 v.81 no.3 pp. 189-294
DOI:10.1007/s12229-015-9157-3
Crystal Structure of the Human Cannabinoid Receptor CB1
Tian Hua, Kiran Vemuri, Mengchen Pu, Lu Qu, Gye Won Han, Yiran Wu,1 Suwen Zhao, Wenqing Shui, Shanshan Li, Anisha Korde, Robert B. Laprairie, Edward L. Stahl, Jo-Hao Ho, Nikolai Zvonok, Han Zhou, Irina Kufareva, Beili Wu, Qiang Zhao, Michael A. Hanson, Laura M. Bohn, Alexandros Makriyannis, Raymond C. Stevens, and Zhi-Jie Liu
Doi: 10.1016/j.cell.2016.10.004
Plant cannabinoids: a neglected pharmacological treasure trove
Raphael Mechoulam
British Journal of Pharmacology (2005) 146, 913–915
doi: 10.1038/sj.bjp.0706415
Cannabidiol Does Not Convert to D9-Tetrahydrocannabinolin an In Vivo Animal Model
Louise Wray,Colin Stott, Nicholas Jones, and Stephen Wright
Cannabis and Cannabinoid Research
Volume 2.1, 2018
DOI: 10.1089/can.2017.0032
Maternal control of seed size in plants
Na Li and Yunhai Li
Journal of Experimental Botany
doi: 10.1093/jxb/eru549
Long term stability of cannabis resin and cannabis extracts
Christian Lindholst
Australian Journal of Forensic Sciences, 42:3, 181-190
Doi: 10.1080/00450610903258144
Ernest Small
The Botanical Review
2015 v.81 no.3 pp. 189-294
DOI:10.1007/s12229-015-9157-3
Crystal Structure of the Human Cannabinoid Receptor CB1
Tian Hua, Kiran Vemuri, Mengchen Pu, Lu Qu, Gye Won Han, Yiran Wu,1 Suwen Zhao, Wenqing Shui, Shanshan Li, Anisha Korde, Robert B. Laprairie, Edward L. Stahl, Jo-Hao Ho, Nikolai Zvonok, Han Zhou, Irina Kufareva, Beili Wu, Qiang Zhao, Michael A. Hanson, Laura M. Bohn, Alexandros Makriyannis, Raymond C. Stevens, and Zhi-Jie Liu
Doi: 10.1016/j.cell.2016.10.004
Plant cannabinoids: a neglected pharmacological treasure trove
Raphael Mechoulam
British Journal of Pharmacology (2005) 146, 913–915
doi: 10.1038/sj.bjp.0706415
Cannabidiol Does Not Convert to D9-Tetrahydrocannabinolin an In Vivo Animal Model
Louise Wray,Colin Stott, Nicholas Jones, and Stephen Wright
Cannabis and Cannabinoid Research
Volume 2.1, 2018
DOI: 10.1089/can.2017.0032
Maternal control of seed size in plants
Na Li and Yunhai Li
Journal of Experimental Botany
doi: 10.1093/jxb/eru549
Long term stability of cannabis resin and cannabis extracts
Christian Lindholst
Australian Journal of Forensic Sciences, 42:3, 181-190
Doi: 10.1080/00450610903258144
False hashish without cannabis resin
Lumír O. Hanuš, Dafna De La Vega, Michael Roman & Pavel Tomíček (2015)
Israel Journal of Plant Sciences, 62:4, 277-282,
DOI: 10.1080/07929978.2015.1053202
Lumír O. Hanuš, Dafna De La Vega, Michael Roman & Pavel Tomíček (2015)
Israel Journal of Plant Sciences, 62:4, 277-282,
DOI: 10.1080/07929978.2015.1053202
Crop physiology of fiber hemp (Cannabis sativa L,)
Hayo van der Werf
Thesis 1994
https://edepot.wur.nl/202103
Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects
Nadia Gulluni , Tania Re , Idalba Loiacono, Giovanni Lanzo, Luigi Gori, Claudio Macchi, Francesco Epifani, Nicola Bragazzi , and Fabio Firenzuoli
Hindawi
Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 1709182, 1-11 pages
doi: 10.1155/2018/1709182
We examined the effects of essential oil from legal (THC <0.2% w/v) hemp variety on the nervous system in 5 healthy volunteers. GC/EIMS and GC/FID analysis of the EO showed that the main components were myrcene and Beta-caryophyllene.The experiment consisted of measuring autonomic nervous system (ANS) parameters; evaluations of the mood state; and electroencephalography (EEG) recording before treatment, during treatment, and after hemp inhalation periods as compared with control conditions. The results revealed decreased diastolic blood pressure, increased heart rate, and significant increased skin temperature. The subjects described themselves as more energetic, relaxed, and calm. The analysis EEG showed a significant increase in the mean frequency of alpha (8–13Hz) and significant decreased mean frequency and relative power of beta 2 (18,5–30Hz) waves.Moreover, an increased power, relative power, and amplitude of theta (4–8Hz) and alpha brain waves activities and an increment in the delta wave (0,5–4Hz) power and relative power was recorded in the posterior region of the brain. These results suggest that the brain wave activity and ANS are affected by the inhalation of the EO of Cannabis sativa suggesting a neuromodular activity in cases of stress, depression, and anxiety.
Novel male-specific molecular markers (MADC5, MADC6) in hemp
Otto Törjek, Nandor Bucherna, Erzsebet Kiss, Hajnalka Homoki, Zsuzsanna Finta-Korpelov, Ivan Bocsa, Istvan Nagy & Laszlo E. Heszky,
Euphytica 127(2): 209–218, 2002.
DOI: 10.1023/A:1020204729122
Sex chromosomes and quantitative sex expression in monoecious hemp (Cannabis sativa L.)
Anne-Michelle Faux • Alice Berhin •Nicolas Dauguet • Pierre Bertin
Euphytica
DOI 10.1007/s10681-013-1023-y
Cannabinoids for the pharmaceutical industry
Colin G. Stott & Geoffrey W. Guy
Euphytica 140: 83–93, 2004
Doi: 10.1007/s10681-004-4757-8
The sexual differentiation of Cannabis sativa L.: A morphological
and molecular study
V.M. Cristiana Moliterni, Luigi Cattivelli, P. Ranalli & Giuseppe Mandolino
Euphytica 140: 95–106, 2004.
DOI: 10.1007/s10681-004-4758-7
Characterisation of cannabinoid composition in a diverse Cannabis sativa L. germplasm collection
Matthew T. Welling, Lei Liu, Tim Shapter, Carolyn A. Raymond, Graham J. King
Euphytica (2016) 208:463–475
DOI 10.1007/s10681-015-1585-y
Hayo van der Werf
Thesis 1994
https://edepot.wur.nl/202103
Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects
Nadia Gulluni , Tania Re , Idalba Loiacono, Giovanni Lanzo, Luigi Gori, Claudio Macchi, Francesco Epifani, Nicola Bragazzi , and Fabio Firenzuoli
Hindawi
Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 1709182, 1-11 pages
doi: 10.1155/2018/1709182
We examined the effects of essential oil from legal (THC <0.2% w/v) hemp variety on the nervous system in 5 healthy volunteers. GC/EIMS and GC/FID analysis of the EO showed that the main components were myrcene and Beta-caryophyllene.The experiment consisted of measuring autonomic nervous system (ANS) parameters; evaluations of the mood state; and electroencephalography (EEG) recording before treatment, during treatment, and after hemp inhalation periods as compared with control conditions. The results revealed decreased diastolic blood pressure, increased heart rate, and significant increased skin temperature. The subjects described themselves as more energetic, relaxed, and calm. The analysis EEG showed a significant increase in the mean frequency of alpha (8–13Hz) and significant decreased mean frequency and relative power of beta 2 (18,5–30Hz) waves.Moreover, an increased power, relative power, and amplitude of theta (4–8Hz) and alpha brain waves activities and an increment in the delta wave (0,5–4Hz) power and relative power was recorded in the posterior region of the brain. These results suggest that the brain wave activity and ANS are affected by the inhalation of the EO of Cannabis sativa suggesting a neuromodular activity in cases of stress, depression, and anxiety.
Novel male-specific molecular markers (MADC5, MADC6) in hemp
Otto Törjek, Nandor Bucherna, Erzsebet Kiss, Hajnalka Homoki, Zsuzsanna Finta-Korpelov, Ivan Bocsa, Istvan Nagy & Laszlo E. Heszky,
Euphytica 127(2): 209–218, 2002.
DOI: 10.1023/A:1020204729122
Sex chromosomes and quantitative sex expression in monoecious hemp (Cannabis sativa L.)
Anne-Michelle Faux • Alice Berhin •Nicolas Dauguet • Pierre Bertin
Euphytica
DOI 10.1007/s10681-013-1023-y
Cannabinoids for the pharmaceutical industry
Colin G. Stott & Geoffrey W. Guy
Euphytica 140: 83–93, 2004
Doi: 10.1007/s10681-004-4757-8
The sexual differentiation of Cannabis sativa L.: A morphological
and molecular study
V.M. Cristiana Moliterni, Luigi Cattivelli, P. Ranalli & Giuseppe Mandolino
Euphytica 140: 95–106, 2004.
DOI: 10.1007/s10681-004-4758-7
Characterisation of cannabinoid composition in a diverse Cannabis sativa L. germplasm collection
Matthew T. Welling, Lei Liu, Tim Shapter, Carolyn A. Raymond, Graham J. King
Euphytica (2016) 208:463–475
DOI 10.1007/s10681-015-1585-y
Classification of Common California Cannabis Cultivars via Secondary Metabolite Characterization
Mark A. Lewis
https://www.medicinalgenomics.com/wp-content/uploads/2016/05/lewis-CannMed2016.pdf
Cannabis. XIV. Two new propyl cannabinoids, cannabicyclovarin and .DELTA.7-cis-iso-tetrahydrocannabivarin, from thai cannabis.
Yukihiro Shoyama, Satoshi Morimoto,Itsuo Nishioka
January 1981CHEMICAL & PHARMACEUTICAL BULLETIN 29(12):3720-3723
DOI: 10.1248/cpb.29.3720
Mark A. Lewis
https://www.medicinalgenomics.com/wp-content/uploads/2016/05/lewis-CannMed2016.pdf
Cannabis. XIV. Two new propyl cannabinoids, cannabicyclovarin and .DELTA.7-cis-iso-tetrahydrocannabivarin, from thai cannabis.
Yukihiro Shoyama, Satoshi Morimoto,Itsuo Nishioka
January 1981CHEMICAL & PHARMACEUTICAL BULLETIN 29(12):3720-3723
DOI: 10.1248/cpb.29.3720
Brother Nature
Well-known member
Here's an interesting one.
Here's an interesting one.
The origins of cannabis smoking: Chemical residue evidence from the first millennium BCE in the Pamirs
Meng Ren, Zihua Tang, Xinhua Wu, Robert Spengle, Hongen Jiang, Yimin Yang and Nicole Boivin
Science Advances 12 Jun 2019:
Vol. 5, no. 6, eaaw1391
DOI: 10.1126/sciadv.aaw1391
https://advances.sciencemag.org/content/5/6/eaaw1391
Here's an interesting one.
The origins of cannabis smoking: Chemical residue evidence from the first millennium BCE in the Pamirs
Meng Ren, Zihua Tang, Xinhua Wu, Robert Spengle, Hongen Jiang, Yimin Yang and Nicole Boivin
Science Advances 12 Jun 2019:
Vol. 5, no. 6, eaaw1391
DOI: 10.1126/sciadv.aaw1391
https://advances.sciencemag.org/content/5/6/eaaw1391
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Please let me know when you can so I can fix any duplicates.
Just give me the titles and Post numbers.
-SamS
Just give me the titles and Post numbers.
-SamS
You can register for free at Jstor and view 6 articles a month I just did and viewed The Induction of Flowering.
https://www.jstor.org/stable/pdf/20494799.pdf?seq=1#metadata_info_tab_contents
https://sci-hub.tw/10.2307/20494799
Studies on flowering-plant growth and organogenesis - III. Leaf shape changes associated with flowering and sex differentiation in Cannabis sativa.
https://www.jstor.org/stable/pdf/20494799.pdf?seq=1#metadata_info_tab_contents
https://sci-hub.tw/10.2307/20494799
Studies on flowering-plant growth and organogenesis - III. Leaf shape changes associated with flowering and sex differentiation in Cannabis sativa.
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