B
bonecarver_OG
me myself i dont know yet how it tastes like, talking about the trinidad scorpion morouga blend.. i will try to taste a small slice but with FEAR hehe
peace
peace
Capsaicin and RTX are the most commonly studied vanilloid agonists. The ability of capsaicin, used in high doses topically or systemically, to produce a novel type of analgesia was discovered by Nicholas Jancso (8). RTX is an irritant component of a cactus-like plant, Euphorbia resinifera. Because capsaicin and RTX share a vanillyl group essential for their activity (although they differ in the rest of the molecule), they are collectively termed vanilloids. RTX are much more potent than capsaicin. Their potency differences are variable depending on the assays. For Ca2+ uptake in DRG neurons, RTX is approximately 300-fold more potent; with desensitization of the urinary bladder to subsequent challenge, it is approximately 1000-fold more potent (2). At the same time, with activation of the cloned TRPV1, RTX is only 20-fold more potent than capsaicin (1). According to Szallasi and Blumberg (2), compared to capsaicin, RTX has a much wider therapeutic margin of safety (prevention of neurogenic inflammation vs. respiratory paralysis). Neuronal excitation caused by capsaicin is much more pronounced than that caused by RTX. Current-clamp experiments reveal that both capsaicin and RTX produce sustained membrane depolarization, but capsaicin generated a significantly greater number of action potentials (9). The generation of action potentials probably depends on the rate of the channel opening. Cation influx with RTX is probably less rapid than with capsaicin. That may be the reason why with intravesicular instillation of these vanilloids (for the treatment of urinary bladder hyperreflexia) RTX caused much less initial irritation in treated patients than capsaicin (10).