Coronavirus.. outlook

[Swamp Thang]

New COVID-19 Variant With 46 Mutations Discovered In Southern France

Since its arrival in late November, the unquestionably mild Omicron strain of Covid-19 has sent daily new infections to record highs, while hospital admissions - and particularly deaths - have remained relatively low compared to the giant new denominator.

But it was only a matter of time before a new variant hit the scene. Like omicron, it appears this new variant originated in an African country - Cameroon - after being isolated by scientists in southern France.

The first official case is reported to be a traveler from Cameroon, and it's now spreading in Southern France where at least 12 people have been infected with it, according to research published on medrvix.

To be clear - we know virtually nothing about this new strain aside from the fact that it exists. Nothing on severity, transmissibility, 'long covid', etc. We do know it's highly mutated from the original strain, much like Omicron. It's also too soon to tell if it will be classified as a 'variant of concern.'

In the medrvix preprint, which has yet to be peer-reviewed, experts from a French government-backed program said they had identified 46 mutations in the variant.

"SARS-CoV-2 variants have become a major virological, epidemiological and clinical concern, particularly with regard to the risk of escape from vaccine-induced immunity," the paper's authors wrote.​

The scientists also postulated that the new variant was probably of "Cameroonian" origin. Readers can find the complete report below. The variant has been given the name B.1.640.2, and was first detected by experts at the IHU Mediterranee Infection Foundation in Marseille.

According to the paper, the scientists' analysis of the variant's genome revealed 46 mutations and "37 deletions resulting in 30 amino acid substitutions and 12 deletions. Fourteen 43 amino acid substitutions, including N501Y and E484K, and 9 deletions are located in the 44 spike protein."

Read the full report below:

https://www.scribd.com/document/550734805/2021-12-24-21268174v1-full#from_embed

Holy chit. Just when you start to think the worst is over, the monster reawakens and resumes its attack wearing a new costume. Isolation fatigue will certainly drive a lot of people completely bonkers around the world, and the major ongoing surge in airline passenger wig-outs is probably just the tip of the proverbial iceberg.

 

[f-e]

It's always Africa. High rate of transmission before detection, limiting the chance of finding and quarantining it early on.
Coffee, Cotton, Copper and Iron. Petroleum mainly. Uranium and Diamonds are not big exports. Internal trade is mostly food, and it see's no boarders as smuggling is what you do, whenever you go shopping (JK). The economies size is impossible to judge because of these movements. Every virus would want to be born there. If it wasn't inhospitably hot and dry. Yet from there it comes. A country where the peoples immune systems offer a record of little historic exposure.

 

[mexcurandero420]

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant


Abstract

The rapid accumulation of mutations in the SARS-CoV-2 Omicron variant that enabled its outbreak raises questions as to whether its proximal origin occurred in humans or another mammalian host. Here, we identified 45 point mutations that Omicron acquired since divergence from the B.1.1 lineage. We found that the Omicron spike protein sequence was subjected to stronger positive selection than that of any reported SARS-CoV-2 variants known to evolve persistently in human hosts, suggesting a possibility of host-jumping. The molecular spectrum of mutations (i.e., the relative frequency of the 12 types of base substitutions) acquired by the progenitor of Omicron was significantly different from the spectrum for viruses that evolved in human patients, but resembled the spectra associated with virus evolution in a mouse cellular environment. Furthermore, mutations in the Omicron spike protein significantly overlapped with SARS-CoV-2 mutations known to promote adaptation to mouse hosts, particularly through enhanced spike protein binding affinity for the mouse cell entry receptor. Collectively, our results suggest that the progenitor of Omicron jumped from humans to mice, rapidly accumulated mutations conducive to infecting that host, then jumped back into humans, indicating an inter-species evolutionary trajectory for the Omicron outbreak.

https://www.sciencedirect.com/science/article/pii/S1673852721003738

 

[St. Phatty]

2.530 new cases and 9 new deaths in the Netherlands today.

That's one way to make room for Facebook's new data center.

https://www.google.com/search?q=Netherlands+Facebook's+new+data+center

 

[Sunshineinabag]

New COVID-19 Variant With 46 Mutations Discovered In Southern France

Since its arrival in late November, the unquestionably mild Omicron strain of Covid-19 has sent daily new infections to record highs, while hospital admissions - and particularly deaths - have remained relatively low compared to the giant new denominator.

But it was only a matter of time before a new variant hit the scene. Like omicron, it appears this new variant originated in an African country - Cameroon - after being isolated by scientists in southern France.

The first official case is reported to be a traveler from Cameroon, and it's now spreading in Southern France where at least 12 people have been infected with it, according to research published on medrvix.

To be clear - we know virtually nothing about this new strain aside from the fact that it exists. Nothing on severity, transmissibility, 'long covid', etc. We do know it's highly mutated from the original strain, much like Omicron. It's also too soon to tell if it will be classified as a 'variant of concern.'

In the medrvix preprint, which has yet to be peer-reviewed, experts from a French government-backed program said they had identified 46 mutations in the variant.

"SARS-CoV-2 variants have become a major virological, epidemiological and clinical concern, particularly with regard to the risk of escape from vaccine-induced immunity," the paper's authors wrote.​

The scientists also postulated that the new variant was probably of "Cameroonian" origin. Readers can find the complete report below. The variant has been given the name B.1.640.2, and was first detected by experts at the IHU Mediterranee Infection Foundation in Marseille.

According to the paper, the scientists' analysis of the variant's genome revealed 46 mutations and "37 deletions resulting in 30 amino acid substitutions and 12 deletions. Fourteen 43 amino acid substitutions, including N501Y and E484K, and 9 deletions are located in the 44 spike protein."

Read the full report below:

https://www.scribd.com/document/550734805/2021-12-24-21268174v1-full#from_embed

So I ask myself reading this think of all the Gram-negative infections that America has just in its hospitals alone antibiotics anyting be becoming more and more obsolete. Seems to me that this thing starting to mutate and become uglier and uglier and uglier until three-quarters of the population can survive it

 

[Swamp Thang]

It's always Africa. High rate of transmission before detection, limiting the chance of finding and quarantining it early on.
Coffee, Cotton, Copper and Iron. Petroleum mainly. Uranium and Diamonds are not big exports. Internal trade is mostly food, and it see's no boarders as smuggling is what you do, whenever you go shopping (JK). The economies size is impossible to judge because of these movements. Every virus would want to be born there. If it wasn't inhospitably hot and dry. Yet from there it comes. A country where the peoples immune systems offer a record of little historic exposure.

The coronavirus originated from Wuhan China, and even after the pandemic spread around the world, African nations have for unknown reasons experienced comparatively low infection and death rates from covid, despite their high population densities and poor medical infrastructure. This paradox remains one of the enduring mysteries of the ongoing pandemic. Bill Gates predicted Africans would drop dead "in the streets" like so many flies, but that expectation simply has not materialized thus far, even as covid's various mutations have emerged.

 

[f-e]

I heard the malaria tablets were likely helping them, and the fact you can't call a death covid related, if you are not actually testing. Here in the UK, the African population looks very different in the figures. Though I have not been to Africa myself to see what's really happening.
If they are not dying from it, that's actually weight to the obscure message I was giving. Though not an angle I was looking at.

Interesting..

 

[armedoldhippy]

wifes kin in Kentucky both tested positive after our 12 day trip there and to LA with them. our tests came back "negative" , but were tagged as "viral load may have been too low to detect with this type of test" just as my first one did last summer. this time, at least, the lady that did the nasal swab was not trying to bore a hole out through the back of my skull with the swab. no blood at all!

 

[mexcurandero420]

Source: NIAID/NIH
By

Georgios Georgiou
+FollowJanuary 9, 2022, 10:27 AM ESTUpdated onJanuary 9, 2022, 7:12 PM EST
A Cypriot scientist defended his assertion that a new strain of Covid-19 exists that combines characteristics of the delta and omicron variants.

Other scientists have speculated that Leonidos Kostrikis’s findings are a result of laboratory contamination. But he told Bloomberg in an emailed statement Sunday that the cases he has identified “indicate an evolutionary pressure to an ancestral strain to acquire these mutations and not a result of a single recombination event.”

See also: Cyprus Finds Covid-19 Infections That Combine Delta and Omicron

Deltacron infection is higher among patients hospitalized for Covid-19 than among non-hospitalized patients, so that rules out the contamination hypothesis, said Kostrikis, a professor of biological sciences at the University of Cyprus and head of the Laboratory of Biotechnology and Molecular Virology.

What’s more, the samples were processed in multiple sequencing procedures in more than one country. And at least one sequence from Israel deposited in a global database exhibits genetic characteristics of deltacron, he said.

“These findings refute the undocumented statements that deltacron is a result of a technical error,” Kostrikis said.

Viral genes determine the forms of proteins that perform a number of specific tasks. Omicron and delta each have mutations in the spike protein that affect their ability to enter human cells, with omicron becoming more infectious as a result.

Recombinant forms of viruses can arise when there are multiple variants of a pathogen circulating, said Nick Loman, a microbial genomics professor at England’s University of Birmingham who studies the coronavirus. While a recombinant form of delta and omicron wouldn’t be a complete surprise, the finding from Cyprus is more likely a “technical artifact” that arose in the process of sequencing the viral genome, he said.

 

[Budz Lightyear]

Lmao - "DELTACRON" - pffthahaha

 

[Budz Lightyear]

Coming soon in 2022 to a TV near you:

Menengeasels (Menengits x Measles)
Flaids (Flu x aids)
Chicken little (Chicken pox x Small pox)
Mold (mumps x cold)
Pigs might fly (swine flu x bird flu)

If Omicron is (Delta x Cold) then Deltacron is just Omicron bx1, loool

 

[Swamp Thang]

Coming soon in 2022 to a TV near you:

Menengeasels (Menengits x Measles)
Flaids (Flu x aids)
Chicken little (Chicken pox x Small pox)
Mold (mumps x cold)
Pigs might fly (swine flu x bird flu)

If Omicron is (Delta x Cold) then Deltacron is just Omicron bx1, loool

Hey. I'll take one of each with a side order of fries, and a strawberry shake to go, but make it snappy.

 

[mexcurandero420]

T cells from common colds cross-protect against infection with SARS-CoV-2


https://www.imperial.ac.uk/news/233018/cells-from-common-colds-cross-protect-against/

 

[star crash]

this is depressing News ..

 

[Budz Lightyear]

this is depressing News ..

Why? Omicron is much less severe and gives natural immunity and antibodies against delta and other previous versions... I mean variants. This is the beginning of the end of the pandemic. It is now an endemic. Thats 1.3 million people that now have natural immunity and antibodies. Dont be depressed.

 

[airplane]

Nastradomnuss says there is going to be another New virus this year (2022) - what next !!!!!!!!!!!!!!!!! call it population control

 

[airplane]

Nastradamass says there is gong to be a NEW Virus this years in 2022 - seems he has been right on alot of things - comes down to interpation of

 

[armedoldhippy]

Why? Omicron is much less severe and gives natural immunity and antibodies against delta and other previous versions... I mean variants. This is the beginning of the end of the pandemic. It is now an endemic. Thats 1.3 million people that now have natural immunity and antibodies. Dont be depressed.

because in spite of being less severe, some folks (not as many, so far) still get bad cases, get sick, and die, as well as giving it to others. natural immunity is not as long lasting like they hoped either. that is why...

 

[Budz Lightyear]

because in spite of being less severe, some folks (not as many, so far) still get bad cases, get sick, and die, as well as giving it to others. natural immunity is not as long lasting like they hoped either. that is why...

And yet people arent freaking out about the common cold or influenza, which both appear to be more serious than Omicron, and have been killing hundreds of thousands of people every year for decades of recorded history. At this point, given what we know about Omicron, its time for society to come out from behind the sofa.

 

[armedoldhippy]

And yet people arent freaking out about the common cold or influenza, which both appear to be more serious than Omicron, and have been killing hundreds of thousands of people every year for decades of recorded history. At this point, given what we know about Omicron, its time for society to come out from behind the sofa.

source for "hundreds of thousands" dying from flu/common cold? at this point, we don't know shit from shinola about long-term effects of Omicron. your meme? bullshit. folks with several of those diseases (ebola for example) would NOT be out shopping etc. many would be too busy dying in isolation. case fatality rates vary from 25% to 90% for ebola.