This is a huge reason I advocate folks going with a co2 generator. You can always run over to the store and grab a 20# tank for ~$20. Not to mention the savings and convenience pay for the investment your very first crop. I'll never use bottled co2 again.Generally yes but, really depends how sealed your room is. For instance, my main room I sealed as tight as i could, wrapping the whole room in orca film on the walls and panda film on the ceiling. Taped over every seam and over every staple used to hang the films. When this room runs out of it's tank the ppm drops to around 30 ppm. This is very detrimental.
Another room I just half assed it when it came to sealing and even without supplemental co2 will stay around 300 ppm, right around atmospheric conditions. Not so detrimental. Of course the downside to this is I blow through tanks way faster in the not so sealed room.
Never a bad idea to have a spare tank on the ready because trust me, your tank will run out at 5:00 pm on friday and you'll be waiting till Monday morning to get it filled lol.