Awesome info @goingrey and @therevverendCome to think of it I talked about seeds but I didn't answer the question, what variation in seed size means.
goingrey provides answers here. There's a lot more range in seed size in an open pollinated sample then in a limb that's been brushed with pollen on an otherwise sinsemilla plant. The open pollinated seeds were hit with pollen over time while the brushed on seeds were pollinated at once. I've found the seeds that are pollinated first are always bigger. The seeds pollinated later will be smaller. We see this pattern in the open pollinated seeds. The brushed on seeds are the same size because they had the same amount of time to mature.
Often I'll let pollen fly early in the season, when the males are beginning to open a few flowers and there's very few calyxes on the females ready for pollination. I get more careful as the females develop bristles and stash the males far away from the females. So a lot of early pre-hairs end up pollinated. These seeds are always huge because they have lots of time to mature and catch the plant when it has the most energy.
Later in the season when things are winding down the plant has less energy reserves. It's getting closer to autumn and the plant is 'rushing' to finish in time. There's still time for seeds to mature but barely. Many times I'll leave a branch to mature long after I've harvested the rest of the plant. If I wasn't able to pollinate it at the opportune time. These seeds are usually smaller then the seeds on limbs that were pollinated earlier.