I just posted about a similar topic in another thread. I am growing perpetual and I try to stick within VPD parameters, except two hours before lights off when I have a dehuey kick in to start drying out the air in anticipation of the RH spike at lights off. Humid air will quickly reach dew point at lights off, your buds will be dripping with moisture. That is the only time you should experience problems with higher humidity assuming your air circulation is on point!
Maybe I will give this a try.. or wonder if its better overall to keep humidity and temps up, at least temps and humidity up to mid 70's with lights off, if that would prevent moisture from forming. Or maybe the plants would not care going from 85 F and 75% humidity and then down to 75 F and 45 humidity, wonder if that large change in humidity would bother them.
I never allow my RH above 70% with lights out due to the threat of mold/bud rot. I turn off my humidifier and turn on my dehumidifier before lights out because as the temp drops the RH will necessarily rise. It sounds like a funny game, but I'm specifically trying to use VPD or a higher RH to overcome heat issues from using a Gavita Pro in a 5x5 tent without AC and couldn't be happier with the results. VPD for the win ;-)~