It is risky to try and mount an A/C unit vertical instead of the expected and designed horizontal. I wouldn't do it. I know this highly not recommended for refrigerators. There is some kind of oil in the compressor that runs into the freon lines and causes big issues. I don't know if a portable A/C unit has the same problem, but I would research it with the exact manufacturer and model before attempting it. The normal advice I have heard is to avoid even transporting a fridge on it's side in the bed of a truck. If you must, let it sit at least 24 hours before turning it on to allow all the compressor oil to drain back to where it should be.
I have never seen a window A/C unit that will exchange air between inside and outside. It seems very inefficient. Heat and humidity come in, costing you money and comfort. I guess it could be possible, check the owner's manual for each model you consider.
-r2k