Nice read although not a peer reviewed source, looking at the author I think we can assume it is accurate. A lesson for all growers is that mono culture doesn't work.
(Beyond Pesticides July 18, 2016) A review of the scientific literature links glyphosate, one of the most popular weed killers in the U.S. and the active ingredient in Roundup, to a wide range of diseases through a mechanism that modifies DNA functioning, adding a new even more troubling dimension to the herbicide’s cancer classification by the International Agency for Research on Cancer. According to the most recent review, Glyphosate pathways to modern disease V: Amino acid analogue of glycine in diverse proteins, conducted by independent scientists Anthony Samsel, Ph.D. and Stephanie Seneff, Ph.D., a scientist at Massachusetts Institute of Technology (MIT), glyphosate acts as a glycine analogue that incorporates into peptides during protein synthesis. In thus process, it alters a number of proteins that depend on conserved glycine for proper function. According to the authors, glyphosate substitution for glycine correlates with several diseases, including diabetes, obesity, asthma, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease, among others.DNA
Glycine, the smallest amino acid commonly found in proteins, has unique properties that support flexibility and the ability to anchor to the plasma membrane or the cytoskeleton. This new direct biological evidence, taken together with correlational data, make a compelling case that glyphosate action as a glycine analogue accounts for much of glyphosate’s toxicity, according to the study. The authors find that glyphosate as an amino acid analogue of glycine, may be incorporated into polypeptide chains during protein synthesis. In doing so, it has an impact on the structure and function of the proteins. Proteins fold up, and glycine is a small molecule that is often found at the folding places. Since glyphosate is much larger, it prevents the protein molecule from folding properly, leading to the disruption of function of many proteins with essential roles in metabolism and regulatory processes
The article cites a number of ways that this affects humans and other organisms. According to the study, the consequences of this action can lead to impaired fatty acid release leading to obesity, impaired insulin receptor response leading to diabetes, impaired one-carbon metabolism leading to neural tube defects and autism, impaired cell cycle control during DNA synthesis, and disregulated phosphorylation cascades leading to cancer, lung disorders, and autoimmune diseases.
Stephen Frantz, Ph.D., a pathobiologist research scientist who led the research team explains it like this: “When a cell is trying to form proteins, it may grab glyphosate instead of glycine to form a damaged, mis-folded protein. After that it’s medical chaos. Where glyphosate replaces glycine, the cell can no longer conduct business as usual causing unpredicted consequences with many diseases and disorders as a result.”
The release of this study comes on the heels of several other discussions and actions on glyphosate that have taken place over the past few weeks. Last month at a Congressional briefing sponsored by U.S Representative Ted Lieu, a delegation of independent scientists including this study’s authors who presented their findings, urged lawmakers to call on the EPA to ban RoundUp, Monsanto’s flagship herbicide. Beyond Pesticides participated on the panel, providing testimony on the impact of glyphosate on soil systems, as well as the unreasonable risk it poses to humans, animals, and the environment. Following the congressional briefing, scientists spoke at a closed meeting with the Environmental Protection Agency (EPA), explaining the physiological reasons why exposure to glyphosate, the active ingredient in RoundUp, is linked to autism, Alzheimer’s, cancer, birth defects, obesity, gluten intolerance, among other health issues. EPA’s Office of Pesticide Programs’ Deputy Director along with his staff met with the panelists and provided an overview of EPA’s registration process for glyphosate. EPA staff had some interest in the information presented, which was forwarded to relevant staffers. However, EPA indicated that much of the information provided may not impact their current risk assessment for glyphosate, which is expected sometime in 2017.
Glyphosate, created by Monsanto, is touted as a “low toxicity” chemical and “safer” than other chemicals by industry. But glyphosate has been shown to have detrimental impacts on humans and the environment. Given its widespread use on residential and agricultural sites, its toxicity is of increasing concern. In early 2015, glyphosate was classified by the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) of as a “probable human carcinogen.” Just a few months later, a study published in Environmental Health News found that chronic, low-dose exposure to glyphosate led to adverse effects on liver and kidney health. Roundup formulations can also induce a dose-dependent formation of DNA adducts (altered forms of DNA linked to chemical exposure, playing a key role in chemical carcinogenesis) in the kidneys and liver of mice. Human cell endocrine disruption on the androgen receptor, inhibition of transcriptional activities on estrogen receptors on HepG2, DNA damage and cytotoxic effects occurring at concentrations well below “acceptable” residues have all been observed.
Roundup also harms crops’ ability to capture carbon from the air, an important factor in fighting climate change. “Glyphosate negatively affects the soil microbiome,” said Frantz. “It is destroying the ability of soil to be a nutritive medium for producing crops. Organic or biological regenerative agriculture is the solution for the sustainable agricultural sector and will conserve soil, air and water quality, and sequester carbon that helps to mitigate the climate crisis. We call for a ban on glyphosate.”
Beyond Pesticides urges individuals concerned about glyphosate exposure to support organic systems that do not rely on hazardous carcinogenic pesticides. In agriculture, concerned consumers can buy food with the certified organic label, which not only disallows synthetic pesticides like glyphosate, but also the use of sewage sludge and genetically engineered ingredients. Beyond Pesticides also urges the adoption of organic lawn and landscape programs.
All unattributed positions and opinions in this piece are those of Beyond Pesticides.
Source: Research Gate, Huffington Post
LONDON — The controversy over genetically modified crops has long focused on largely unsubstantiated fears that they are unsafe to eat.
But an extensive examination by The New York Times indicates that the debate has missed a more basic problem — genetic modification in the United States and Canada has not accelerated increases in crop yields or led to an overall reduction in the use of chemical pesticides.
The promise of genetic modification was twofold: By making crops immune to the effects of weedkillers and inherently resistant to many pests, they would grow so robustly that they would become indispensable to feeding the world’s growing population, while also requiring fewer applications of sprayed pesticides.
Twenty years ago, Europe largely rejected genetic modification at the same time the United States and Canada were embracing it. Comparing results on the two continents, using independent data as well as academic and industry research, shows how the technology has fallen short of the promise.......
Bayer agrees to $10.9bn settlement over Monsanto’s weedkiller Roundup
Numerous lawsuits have been brought against the pharmaceutical subsidiary over claims the chemical causes cancer
Guardian staff and agencies
Wed 24 Jun 2020 20.07
Bayer has reached a $10.9bn settlement over Monsanto’s Roundup weedkiller.
German pharmaceutical company Bayer says it’s paying up to $10.9bn to settle a lawsuit over subsidiary Monsanto’s weedkiller Roundup, which has faced numerous lawsuits over claims it causes cancer.
Bayer said it was also paying up $1.22bn to settle two further cases, one involving polychlorinated biphenyl (PCB) in water.
Bayer said the Roundup settlement would “bring closure to approximately 75%” of the current 125,000 filed and unfiled claims. The resolution also puts in place a mechanism to resolve potential future claims, the company said.
“First and foremost, the Roundup settlement is the right action at the right time for Bayer to bring a long period of uncertainty to an end,” said Werner Baumann, CEO of Bayer, in a statement on Wednesday.
Bayer said the agreement is subject to approval by Judge Vince Chhabria of the US district court for the northern district of California.
Three Roundup cases that have gone to trial in recent years are not covered by the settlement and will continue through the appeals process, Bayer said.
A California jury ordered Monsanto in May 2019 to pay more than $2bn to Alva and Alberta Pilliod, a couple that got cancer after using Roundup.
The victory for the Pilliods was the latest in a series of trial wins taking on Monsanto over Roundup. Dewayne Johnson, a former school groundskeeper with terminal cancer, won a $289m victory in a California court in 2018, and Edwin Hardeman, who sprayed Roundup on his properties, was awarded $80m in the first federal trial in 2019.
Bayer has appealed all three rulings.
Bayer said it would also pay up to $400m to settle cases involving the weedkiller dicamba having drifted onto plants that weren’t bred to resist it, killing them.
A further payment of up to $820m will be made to settle “most” claims for exposure to PCB, a highly carcinogenic substance, that Monsanto produced until 1977 and which has been found in US waters.
Bayer said it would start making payments this year and these would be financed from existing liquidity, future income, proceeds from the sale of its animal health business and the issuance of additional bonds.
The US Environmental Protection Agency (EPA) ruled last year that it was false to say glyphosate, the herbicide marketed as Roundup, caused cancer, and recently issued a report concluding the product did not cause risks to human health when used correctly. Advocates have long criticized the EPA’s continued approval of Roundup in the face of research linking the herbicide to cancer.
“Even Bayer’s billions can’t magically make glyphosate’s well-documented links to cancer disappear,” Nathan Donley, senior scientist at the Center for Biological Diversity, said in a statement. “Bayer only settled after three multi-million-dollar verdicts over the past year from jurors who, unlike the EPA, wisely put more trust in the safety assessments of independent scientists than in Monsanto/Bayer’s confidential reviews of its own product.”
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yes grass killer sprayed every year in same spot after a few years nothin will grow