Learn how Cannabinoids kill cancer! Part 1: Reducing VEGF (Show people this!)

[monkey5]

BiOhazard, Great information! Thank you for making this thread! Sweet stuff! monkey5

 

[Frozenguy]

http://www.jci.org/articles/view/37948 - Journal of Clinical Investigation

Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain

Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3–dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.

 

[Hash Zeppelin]

I wonder what the CDN levels were on your BHO..

“CBN” = cannabinol – Formed when CBNA is heated (or exposed to UV light). Sedative, antibacterial(MRSA), Treats Burns, psoriasis, breast cancer

Probably quite high. It was made from 8 week indicas I let go 9 weeks for chron's meds.

 

[eyes]

maybe im missing it.... is the adminstered dose by way of smoking or ingesting or topical through oils? what method are they using throughout the studies?