S
strandloper
http://www.futurity.org/marijuana-topamax-side-effects-1091132-2/
"Combining the drug topiramate with psychological counseling curbs marijuana use among young smokers significantly more than counseling alone, according to new small study. But the results come with a caveat: Many study volunteers couldn’t tolerate the side effects.
Through consistent interviews and other means during the study, volunteers recalled how often they smoked and how much (urine tests also showed whether they were using marijuana and also taking either the medicine or placebo). Both groups reduced the number of days on which they used marijuana by statistically similar amounts, but those who took the medication also used on average about 0.2 fewer grams of cannabis each time.
While Miranda says he is encouraged by the results showing a significant additional effect from the medication, it was clear the treatment was not for everyone. At the end of the six-week study, 21 of the 40 subjects receiving the drug had dropped out compared to only six of the 26 people taking the placebo. Two-thirds of those who left the study after using topiramate cited the side effects as their reason for leaving. They complained of problems such as depression, anxiety, trouble with coordination and balance, weight loss, and unusual sensations."
"Combining the drug topiramate with psychological counseling curbs marijuana use among young smokers significantly more than counseling alone, according to new small study. But the results come with a caveat: Many study volunteers couldn’t tolerate the side effects.
Through consistent interviews and other means during the study, volunteers recalled how often they smoked and how much (urine tests also showed whether they were using marijuana and also taking either the medicine or placebo). Both groups reduced the number of days on which they used marijuana by statistically similar amounts, but those who took the medication also used on average about 0.2 fewer grams of cannabis each time.
While Miranda says he is encouraged by the results showing a significant additional effect from the medication, it was clear the treatment was not for everyone. At the end of the six-week study, 21 of the 40 subjects receiving the drug had dropped out compared to only six of the 26 people taking the placebo. Two-thirds of those who left the study after using topiramate cited the side effects as their reason for leaving. They complained of problems such as depression, anxiety, trouble with coordination and balance, weight loss, and unusual sensations."
