Late to the game here but I thought I'd chime in.
Me: studied genetics and the molecular biology of plants in grad school and worked in related disciplines for many years.
The plant's genetics aren't going to change in any meaningful way. The phenotype probably will. Variance in phenotype amongst clonal generations can be attributed to variation in the expression of the genes in response to environment or (earlier on, e.g. from seed) age. The genes don't change but which ones are turned on or how much they are turned on changes (many genes are not on/off but more like a volume knob). As a mother ages it is entirely likely (i.e. expected) that the spectrum of regulatory chemicals (hormones, etc.) is going to change over time. When you clone a plant the clone will start out with the same hormonal regime that the mother had. Example: if you are stressing your plant then the clone starts out its life in a state that is meant for dealing with stress, not one that is meant for dealing with being a little girl that wants to grow up. Just like people, plants can have a hard time overcoming a rough start and that roughness can be passed down through the generations and might take a while to work itself out even in otherwise good conditions.
If you want stability across clonal generations then you may have better success if you are very nice to your mothers and if you carefully maintain a stable, non-stressful environment. Careful with nutes, watering, light, don't let them get root-bound, etc.. Even then, some plants may not age gracefully and you will be better off to regularly replace your mothers...other mothers might be stable for years. You have to find what works and then stick to it.
Me: studied genetics and the molecular biology of plants in grad school and worked in related disciplines for many years.
The plant's genetics aren't going to change in any meaningful way. The phenotype probably will. Variance in phenotype amongst clonal generations can be attributed to variation in the expression of the genes in response to environment or (earlier on, e.g. from seed) age. The genes don't change but which ones are turned on or how much they are turned on changes (many genes are not on/off but more like a volume knob). As a mother ages it is entirely likely (i.e. expected) that the spectrum of regulatory chemicals (hormones, etc.) is going to change over time. When you clone a plant the clone will start out with the same hormonal regime that the mother had. Example: if you are stressing your plant then the clone starts out its life in a state that is meant for dealing with stress, not one that is meant for dealing with being a little girl that wants to grow up. Just like people, plants can have a hard time overcoming a rough start and that roughness can be passed down through the generations and might take a while to work itself out even in otherwise good conditions.
If you want stability across clonal generations then you may have better success if you are very nice to your mothers and if you carefully maintain a stable, non-stressful environment. Careful with nutes, watering, light, don't let them get root-bound, etc.. Even then, some plants may not age gracefully and you will be better off to regularly replace your mothers...other mothers might be stable for years. You have to find what works and then stick to it.