cancer from inhaling bic lighter fumes

[nycdfan042]

err yo no need to turn a thread about lighters n cancer into a political discussion thats just inciting trolling.....
That hot poker thing sounds TIGHT!!! kinda like a vaporizer....very neat might hafta try that!!! prolly works awesome with keif!!!!

 

[Wildfire]

all i know is i dont trust myself with the quality of weed that i smoke and a damn propane torch!

 

[AlaskaGrows]

i have recently enjoyed a vaporizer for the first time.

i bought a Natural Goods Herbal Vaporizer, now i hate using a flame, tastes like shit!

and i feel much better then while i was smoking... still got too sometimes though like at other peoples places..... usually i try to pass but most people take it the wrong way.... oh well they dont pass up the vape!

 

[Tronic]

nycd, sorry man not trying to troll, but rather try and humourously express the hilarity of the topic when above it there is a thread sprouting more possibilities then liberache on halloween. i would have thought bic lighters, especially those mini ones, which are always 'made in france'.... those damn french....

ah who knows, im not one to keep my cell phone on my hip, damn it it goes in my pocket, falls on the ground, and breaks occasionally. same thing with my body, last thing i'm concerned with is the possible harm of the ignition source of my hobby.

just keepin it real man, no troll here. peace.

 

[Wonderkid420]

Jason King of Cannabible fame has said that butane lighters can cover the taste of buds and can also be harmful to your health. Honestly if you're smoking you're smoking, and if lady nicotine has you in her clutches it's kinda pointless to be worried about butane fumes. but thats just me

 

[jekyllandhyde]

A method for treating cancer and inhibiting tumor growth, which comprises administering to a mammal in need of such treatment a therapeutic amount of a compound of the following formula: ##STR70## wherein: W is --O--, --S--, --SO--, --SO2 --, --CO--, C2 -C6 alkylene, substituted alkylene, C2 -C6 alkenylene, -aryl-, -aryl(CH2)m O--, -heterocycle-, -heterocycle-(CH2)m O--, -fused bicyclic-, -fused bicyclic-(CH2)m O--, --NR3 --,--NOR3 --, --CONH--, or--NHCO--;

X and Y are independently C1 -C4 alkylene, substituted alkylene, or together X, Y, and W combine to form (CH2)n --AA--;

R1 is independently hydrogen, halo, C1 -C4 alkyl, hydroxy, C,-C4 alkoxy, haloalkyl, nitro NR4 R5, or --NHCO(C1 -C4 alkyl);

R2 is hydrogen, CH3 CO--, NH2, or hydroxy;

R3 is hydrogen, (CH2)m aryl, C1 -C4 alkyl, --COO(C1 -C4 alkyl), --CONR4 R5, --(C.dbd.NH)NH2, --SO(C1 -C4 alkyl), --SO2 (NR4 R5), or --SO 02 (C1 -C4 alkyl);

R4 and R5 are independently hydrogen, C1 -C4 alkyl, phenyl, benzyl, or combine to the nitrogen to which they are bonded to form a saturated or unsaturated 5 or 6 member ring;

AA is an amino acid residue;

m is independently 0, 1, 2, or 3; and

n is independently 2, 3, 4, or 5; or

a pharmaceutically acceptable salt or solvate thereof.

2. The method of claim 1, wherein R2 is hydrogen.

3. The method of claim 2, wherein the moieties --X--W--Y-- contain 4 to 8 atoms, said atoms being substituted or unsubstituted.

4. The method of claim 3, wherein W is a substituted alkylene, --O--, --S--, or --NR3 --; and R3 is hydrogen, (CH2)m aryl, or C1 -C4 alkyl; and m is 0, 1, 2, or 3.

5. The method of claim 4, wherein the compound is of the formula: ##STR71## wherein: Y is C1 -C4 alkylene or substituted alkylene;

W' is --O--, --S--, or --NR3 --;

R3 is hydrogen, (CH2)m aryl, C1 -C4 alkyl; and

m is independently 2 or 3.

6. The method of claim 5, wherein W' is --O--; and Y is substituted alkylene.

7. The method of claim 6, wherein the compound is of the formula: ##STR72## wherein: Z is --(CH2)p -- or --(CH2)p --O--(CH2)p --;

R6 is hydroxy, --SH, C1 -C4 alkyl, (CH2)m aryl, --NH(aryl), --NR4 R5 --NH(CF3), or N(CF3)(CH3);

R4 is hydrogen or C1 -C4 alkyl;

R5 is hydrogen, C1 -C4 alkyl, benzyl, or combines with R4 and the nitrogen to which they are bonded to form a saturated or unsaturated 5 or 6 member ring;

p is independently 0, 1, or 2; and

m is independently 0, 1, 2, or 3.

8. The method of claim 7, wherein Z is --CH2 --; R6 is --NR4 R5, NH(CF3), or N(CF3)(CH3); and R4 and R5 are methyl.

9. The method of claim 7, wherein the compound is selected from the group consisting of (R)-3,4-�(N,N'-1, 1'-((2"-ethoxy)-3"'(O)-4"'-(N,N-dimethylamino)-butane)-bis-(3,3'-indolyl)! -1(H)-pyrrole-2,5-dione, (S)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'(O)-4"'-(N,N-dimethylamino)-butane)-bi s-(3,3'-indolyl)!-1(H)-pyrrole-2,5-dione, a mixture thereof, or a pharmaceutically acceptable salt or solvate thereof.

10. The method of claim 7, wherein the compound is (S)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'(O)-4"'-(N,N-dimethylamino)-butane)-bi s-(3,3 '-indolyl)!-1 (H)-pyrrole-2,5-dione or a pharmaceutically acceptable salt or solvate thereof.

11. The method of claim 7, wherein the compound is (R)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'(O)-4"'-(N,N-dimethylamino)-butane)-bi s-(3,3'-indolyl)!-1(H)-pyrrole-2,5-dione or a pharmaceutically acceptable salt or solvate thereof.

12. A method for treating cancer and inhibiting tumor growth, which comprises administering to a mammal in need of such treatment a therapeutic amount of a compound selected from the group consisting of (S)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'-(O)-4"'-(N-pyrrolidine)-butane)-bis-( 3,3'-indolyl)!-1(H)-pyrrole-2,5-dione, (R)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'-(O)-4"'-(N-pyrrolidine)-butane)-bis-( 3,3 '-indolyl)!-1(H)-pyrrole-2,5-dione, a mixture thereof, or a pharmaceutically acceptable salt or solvent thereof.

13. The method of claim 12, wherein the compound is (S)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'-(O)-4"'-(N-pyrrolidine)-butane)-bis-( 3,3'-indolyl)!-1(H)-pyrrole-2,5-dione.

14. The method of claim 12, wherein the compound is (R)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'-(O)-4"'-(N-pyrrolidine)-butane)-bis-( 3,3'-indolyl)!-1(H)-pyrrole-2,5-dione.

15. A method for treating cancer and inhibiting tumor growth, which comprises administering to a mammal in need of such treatment a therapeutic amount of a compound selected from the group consisting of (S)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'-(O)-4"'-(N-phenylsulfonamido)-butane) -bis-(3,3'-indolyl)!-1(H)-pyrrole-2,5-dione, (R)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'-(O)-4"'-(N-phenylsulfonamido)-butane) -bis-(3,3'-indolyl)!-1(H)-pyrrole-2,5-dione, a mixture thereof, or a pharmaceutically acceptable salt or solvent thereof.

16. The method of claim 15, wherein the compound is (S)-3,4-�(N,N'-1, 1'-((2"-ethoxy)-3"'-(O)-4"'-(N-phenylsulfonamido)-butane)-bis-(3,3'-indoly l)!-1(H)-pyrrole-2,5-dione.

17. The method of claim 15, wherein the compound is (R)-3,4-�(N,N'-1,1'-((2"-ethoxy)-3"'-(O)-4"'-(N-phenylsulfonamido)-butane) -bis-(3,3'-indolyl)!-1(H)-pyrrole-2,5-dione.

18. The method of claim 10, wherein the pharmaceutically acceptable salt is selected from the group consisting of sulfate, pyrosulfate, bisulfate, sulfite, bisulfite, phosphate, monohydrogenphosphate, dihydrogenphosphate, metaphosphate, pyrophosphate, chloride, bromide, iodide, acetate, propionate, decanoate, caprylate, acrylate, formate, isobutyrate, heptanoate, propiolate, oxalate, malonate, succinate, suberate, sebacate, fumarate, maleate, 2-butyne-1,4-dioate, 3-hexyne-2, 5-dioate, benzoate, chlorobenzoate, hydroxybenzoate, methoxybenzoate, phthalate, xylenesulfonate, phenylacetate, phenylpropionate, phenylbutyrate, citrate, lactate, hippurate, β-hydroxybutyrate, glycolate, maleate, tartrate, methanesulfonate, propanesulfonate, naphthalene-1-sulfonate, naphthalene-2-sulfonate, and mandelate.
Other References

Derwent Abstract 90-132947/18; 21.10.88-DE-835842.
Wilkinson, et al., Bichem. J., 294, 335-337 (1993).
Bit, et al., J. Med. Chem., 36, 21-29 (1993).
Martiny-Baron, et al., The Journal of Biological Chemistry, 268:13, 9194-9197 (1993).
Krakowiak, et al, SYNLETT, 611-620, (Sep. 1993).
Mulqueen, et al., Agents Actions, 37, 85-89 (1992).
Davis, et al., J. Med. Chem., 35, 994-1001 (1992).
Toullec, et al., The Journal of Biological Chemistry, 266:24, 15771-15781 (1991).
Nixon, et al., Drugs Exptl. Clin. Res., 17:8, 389-393 (1991).
Brenner, et al., Tetrahedron Letters, 44:10, 2887-2892 (1988).
Joyce, et al., The Journal of Organic Chemistry, 52:7, 1177-1186 (1987).
Buchdunger, et al., Proc. Natl. Acad. Sci. USA, 91, 2334-2338 (Mar. 1994).
Derwent Abstract 92-274042/33;90.11.20 90JP-314628.
Kobayashi, et al., The American Physiological Society, H1214-H1220 (1994).
Felsenstein, et al., Neuroscience Letters, 174 173-176 (1994).
Demaerschalck, et al., Biochimica et Biophysica Acta, 1181 214-218 (1993).
Shimohama, et al., Neurology, 43 1407-1413 (1993).
Fieser and Fieser, Reagents for Organic Synthesis, XII, John Wiley & Sons, p. 108 (1986).
Meier, et al., Tetrahedron Letter, 34:33, 5277-5280 (1993).
Davis, et al.., J. Med. Chem., 35, 177-184 (1992).
Davis, et al, Tetrahedron Letters, 31:36, 5201-5204 (1990).

 

[George Hayduke]

all i know is i dont trust myself with the quality of weed that i smoke and a damn propane torch!

lol - i agree. i might not burn my house down with it this week, this month, or even this year but if i kept using it i would eventually!

 

[nycdfan042]

MLEEP MLEEP take me to your leader^ oh and tronic...response noted