D
dark horse
Ok let me simplify things..
I would go with the first one, But I would not use a lot of flex duct. I would come out of the top of the cabinet with a short piece of flex duct then use hard duct the rest of the way to the fan then use another short piece of flex duct to connect the fan to the hard duct.
The reason that I would not use flex duct is that you loose a lot of air due the increased static due to the bends in the flex duct, But I would add a short piece 8" to each end this will help the sound from the fan being transmitted through the duct, wall and cabinet.
Keep the duct straight and use as little of bends as possible.
if it were me i'd go with a, the pc fan isn't going to blow more stinky air out than the exhaust fan can suck up, assuming you have a decent size exhaust fan. the closet should contain it all I would think. then again if it were me, i'd scrap the little box and use the whole closet,thereby allowing you the room for a fan AND filter to be hung in your grow
def A. I've done this and it works just fine.
also, would insulated flex be the best route or it don't really matter?
don't know your location...
but, i would not vent warm humid air into attic space.
mold and mildew love that schtuff.
choice A.