Which Cannabinoids cause which effect?

[McFreedom]

Hi,
I might be in the wrong place here, but here goes.

I'd like to learn which Cannabinoids cause what kind of effect.
I know that Sativas generally have less cannabinoids other than THC where as Indicas have more CBD, CBN etc.
Which Cannabinoids contribute to a psychedelic effect? Or which Cannabinoids contribute to a clean effect, or couch lock, energetic effect? I've read somewhere that THCV reduces the munchies.

Is there a comprehensive guide to Cannabinoids?

 

[Chimera]

Almost all the cannabis you will run into on the commercial markets are pretty much exclusively THC. In some markets you can also find samples with CBD, but still the vast majority is THC dominant.

So if they are all pretty much THC, what are the chemical differences that bring the different effects? The answer lies in the terpenes, not the cannabinoids. Terpenes are the majority of chemical class that brings the odor to cannabis. Myrcene is the majority occurring terpene across a range of varieties, but you can also find flowers high in terpinolene, limonene, pinene, etc. What you refer to as indica (accurately afghanica), are really high in Myrcene. Myrcene has a lethargic effect, especially when taken with large amounts of THC.

What you call sativa (correctly indica, thin leaved plants from india) - can be high in pinene, or terpinolene, or limonene. These terpenes typically are interpreted as more uplifting.

Think of the terpene effect something like aromatherapy + THC. The THC provides the power, the terpene profile guides the feeling or effect.

Search out Ethan Russo's Taming THC- the entourage effect on google, or simply search terpenes and cannabis, there is a ton of reading, and I think you'll see pretty quickly that the effect guides the experience more than the cannabinoids.

 

[Betterhaff]

Here is a link to MedicalJane, it has an overview of Cannabinoids and a lot of the other compounds of the plant. In the menu bar there is a section on Terpenes (which also has some info about Flavinoids. Not sure how dated some of this information is but at least it gives some insight.

https://www.medicaljane.com/category/cannabis-classroom/cannabis-science/

 

[Limeygreen]

It will be interesting to see with more legalization happening if the varieties that come out will have lower thc contents but greater effects, to me it would make sense that if all your compounds are present that a thc of 8-12 percent should be sufficient, no need for 20-30 percent. This is just my speculation though and could just be staring at clouds in the sky.

 

[Levitationofme]

Info that I have been given also points to the various terpenes effect the way THC flows from the blood into the brain or some such thing, which also makes sense. I am sure we know very little about this stuff as it is such a "new" legit science.

 

[chronosync]

Well, lmgify: cbg glaucoma

https://www.medicaljane.com/cannabinoid/cbg/

I'm about to have a cup of coffee

 

[Levitationofme]

Good Idea!

 

[chronosync]

Coffee is like cannabis in that it contains a myriad of active compounds that work in synergy, is it surprising I enjoy and employ the synergy they create together?

 

[ThaiBliss]

Almost all the cannabis you will run into on the commercial markets are pretty much exclusively THC.

Greetings,

I really like Chimera's post. It is a very good summary. I have been plowing through a lot of strains and narrowing up my collection to rid myself of couch-lock varieties. In my old age, I have become intolerant of lethargic Cannabis. I have found that the plants that I have been keeping all have significant amounts of limonene, pinene, or both. To my surprise, based on what I've read, some of my keepers also have significant amounts of myrcene.

What I have been finding is that the plants that have significant amounts of myrcene are still tolerable, in fact enjoyable, if they have very low amounts of CBD. It seems that minute differences in CBD amounts have dramatic consequences. What many people consider as insignificant amounts of CBD, 1.0 %, is strikingly different than 0.1% CBD, the former being intolerable to me, but the latter being a pure joy. Another cannabinoid to consider is CBG. This is showing up as a frequent presence in strains I like.

More and more I'm becoming convinced by the arguments that terpenes are central to the discussion of Cannabis effects and it is important to point this out, but I wouldn't "throw the baby out with the bath water" in regard to the entourage effects of the various ratios between cannabinoids, ratios between terpenes, or possibly ratios between specific terpenes and specific cannabinoids. The possible combinations are astronomical and are what makes this genus we call Cannabis so magical.

ThaiBliss