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Gh ph up is some of the shittiest diluted crap on the market.
You can buy the raw ingredients for way way less but there's a liability issue when using pure KOH. Melt your eyes if you fuck up.
Most ph down is phosphoric acid which at normal concentrations and ph's will have zero effect on your microbes. Maybe a different story if you go super overboard but I wouldnt worry about it at all.
The other thing is if youre growing in soil and the ph of your runoff is 6.4 or 6.5 you don't need to adjust your water ph. Do a test and see. Sometimes it doesn't matter what the pH of your water is.
My soil I can feed anywhere from 3.8 pH water to 7.0 and it comes out around 6.6 last I checked. You bring it down with calcium if you need to.