Hey all,
The genesis for this thread was a request from a buddy (VF) who asked for recent studies about CBD. It took me longer than I had hoped to collect all of these, but I have enough to start a good thread I think. There are three other threads* in this science sub-forum that also have some relevant studies where Pipeline, Cannaboloist and myself uploaded many studies. Instead of re-uploading the papers again I will link to relevant posts in other threads were appropriate.
This thread isn't only about CBD and other cannabinoids, it's also about other secondary metabolites like flavonoids and terpenoids (which are not tepenes, even though they come from tepenes, thus calling terpenoids, terpenes, should be avoided).
OK, here goes. I was going to post the title, authors and journal, along with the abstracts, but posting abstracts takes a while because they have to be formatted correctly. I might post the abstracts at a later date, but now I don't have enough time.
1. General studies on various secondary metabolites in cannabis including THC, CBD, CBC, terpenoids, etc.:
"Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts?"
John M. McPartland and Ethan B. Russo
Journal of Cannabis Therapeutics (2001), Vol.1, No.3/4, pp. 103-132
"Comparison of the subjective effects of ∆9-tetrahydrocannabinol and marijuana in humans"
S. R. Wachtel, M. A. ElSohly, S. A. Ross and J. Ambre H. de Wit
Psychopharmacology (2002) 161:331–339
"Cannabis is more than simply ∆9-tetrahydrocannabinol"
Ethan B. Russo and John M. McPartland
Psychopharmacology (2003) 165:431–432
"Cannabis versus THC: response to Russo and McPartland"
Mahmoud A. ElSohly, Stephen R. Wachtel and Harriet Wit
Psychopharmacology (2003) 165:433–434
"Secondary metabolism in cannabis"
Isvett Josefina Flores-Sanchez and Robert Verpoorte
Phytochem Rev (2008) 7:615–639
"Recent advances in Cannabis sativa research: biosynthetic studies and its potential in biotechnology"
Sirikantaramas S, Taura F, Morimoto S, Shoyama Y.
Curr Pharm Biotechnol. 2007 Aug;8(4):237-43
"A historical overview of chemical research on cannabinoids"
Raphael Mechoulam and Lumır Hanus
Chemistry and Physics of Lipids 108 (2000) 1–13
"Cannabis Plant Chemistry"
Montana Medical Grower’s Association, in conjunction with Montana Botanical Analysis
"Chemistry and Analysis of Phytocannabinoids and Other Cannabis Constituents"
Rudolf Brenneisen
From: Forensic Science and Medicine: Marijuana and the Cannabinoids
"Chemical constituents of marijuana: The complex mixture of natural cannabinoids"
Mahmoud A. ElSohly and Desmond Slade
Life Sciences 78 (2005) 539–548
[not so...] "Recent Developments in Cannabis Chemistry"
ALEXANDER T. SHULGIN, Ph.D.
Journal of Psychedelic Drugs, vol. II, no. 1 (1971)
"Human Studies of Cannabinoids and Medicinal Cannabis"
P. Robs on
HEP (2005) 168:719–756
2. Endocannabinoid system and cytokine network:
"Cannabinoids, Immune System and Cytokine Network"
Massi, P.1; Vaccani, A.1; Parolaro, D.1
Current Pharmaceutical Design, Volume 12, Number 24, August 2006 , pp. 3135-3146(12)
"The Cannabinoid System and Cytokine Network"
Thomas W. Klein, Brian Lane, Catherine A. Newton, Herman Friedman
Proceedings of the Society for Experimental Biology and Medicine
Volume 225, Issue 1, pages 1–8, October 2000
"THE ENDOCANNABINOID SYSTEM AND ITS THERAPEUTIC EXPLOITATION"
Vincenzo Di Marzo,Maurizio Bifulco and Luciano De Petrocellis
NATURE REVIEWS, VOLUME 3, SEPTEMBER 2004
"The Endocannabinoid System and the Therapeutic Potential of Cannabinoids"
Billy R. Martin
From: Forensic Science and Medicine: Marijuana and the Cannabinoids
"THE NEURONAL, ENDOCRINE, METABOLIC EFFECTS OF ENDOCANNABINOID SYSTEM AND THE POTENTIAL CLINICAL IMPLICATIONS OF THE CANNABINOID TYPE 1 (CB1) BLOCKER"
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, Vol. 29, Suppl. to No. 3 (2006)
3. Cannabinoids: THC, CBD, etc (natural and synthetic):
"Pharmacological Actions of Cannabinoids"
R. G. Pertwee
Cannabinoids, Handbook of Experimental Pharmacology, 2005, Volume 168, 1-51
"The acute effects of synthetic intravenous D9-tetrahydrocannabinol on psychosis, mood and cognitive functioning"
P. D. Morrison, V. Zois, D. A. McKeown, T. D. Lee, D. W. Holt, J. F. Powell, S. Kapur and R. M. Murray
Psychological Medicine (2009), 39, 1607–1616
"A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol"
Ethan Russo and Geoffrey W. Guy
Medical Hypotheses (2006) 66, 234–246
"Does cannabidiol protect against the negative effects of THC?"
Cécile Henquet and Rebecca Kuepper
The British Journal of Psychiatry, (2010) 197: 259-260
"Cannabidiol potentiates pharmacological effects of D9-tetrahydrocannabinol via CB1 receptor-dependent mechanism"
Kazuhide Hayakawaa, Kenichi Mishimaa, Mai Hazekawaa, Kazunori Sanoa, Keiichi Iriea, Kensuke Oritoc, Takashi Egawaa, Yoshihisa Kitamuraa, Naoki Uchidad, Ryoji Nishimurad, Nobuaki Egashiraa, Katsunori Iwasaki and Michihiro Fujiwara
BRAIN RESEARCH 1188 (2008) 157 – 164
OK, I ran out upload space in this post, I will continue with uploading studies in my next post. Please do not respond to this thread until I am done uploading studies, thanks
The genesis for this thread was a request from a buddy (VF) who asked for recent studies about CBD. It took me longer than I had hoped to collect all of these, but I have enough to start a good thread I think. There are three other threads* in this science sub-forum that also have some relevant studies where Pipeline, Cannaboloist and myself uploaded many studies. Instead of re-uploading the papers again I will link to relevant posts in other threads were appropriate.
* there are two separate threads with the same topic, one is by Pipeline and one by Cananboloist. I think they should be merged into one thread because they both are for the same thing: uploading cannabis specific scholarly papers/research. I think having two of the same threads makes finding studies less easy. The thread by Pipeline was first, so I am humbly ask OldPink (or any other mod) to merge Cannabologist's thread into Pipeline's thread. The third thread is mine, it's a 'request' thread where people can post studies they want to read, but don't have access to. Then myself and others, do our best to get the requested studies and upload them for our fellow Icers.
I will add to this thread as time goes on, but for now I have maybe a dozen or two papers to upload. That should be enough for now, I hope
This thread isn't only about CBD and other cannabinoids, it's also about other secondary metabolites like flavonoids and terpenoids (which are not tepenes, even though they come from tepenes, thus calling terpenoids, terpenes, should be avoided).
OK, here goes. I was going to post the title, authors and journal, along with the abstracts, but posting abstracts takes a while because they have to be formatted correctly. I might post the abstracts at a later date, but now I don't have enough time.
1. General studies on various secondary metabolites in cannabis including THC, CBD, CBC, terpenoids, etc.:
"Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts?"
John M. McPartland and Ethan B. Russo
Journal of Cannabis Therapeutics (2001), Vol.1, No.3/4, pp. 103-132
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4058582&postcount=46
"Comparison of the subjective effects of ∆9-tetrahydrocannabinol and marijuana in humans"
S. R. Wachtel, M. A. ElSohly, S. A. Ross and J. Ambre H. de Wit
Psychopharmacology (2002) 161:331–339
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4058582&postcount=46
"Cannabis is more than simply ∆9-tetrahydrocannabinol"
Ethan B. Russo and John M. McPartland
Psychopharmacology (2003) 165:431–432
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4058582&postcount=46
"Cannabis versus THC: response to Russo and McPartland"
Mahmoud A. ElSohly, Stephen R. Wachtel and Harriet Wit
Psychopharmacology (2003) 165:433–434
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4058582&postcount=46
"Secondary metabolism in cannabis"
Isvett Josefina Flores-Sanchez and Robert Verpoorte
Phytochem Rev (2008) 7:615–639
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4058582&postcount=46
"Recent advances in Cannabis sativa research: biosynthetic studies and its potential in biotechnology"
Sirikantaramas S, Taura F, Morimoto S, Shoyama Y.
Curr Pharm Biotechnol. 2007 Aug;8(4):237-43
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4051350&postcount=21
"A historical overview of chemical research on cannabinoids"
Raphael Mechoulam and Lumır Hanus
Chemistry and Physics of Lipids 108 (2000) 1–13
- uploaded to this post
"Cannabis Plant Chemistry"
Montana Medical Grower’s Association, in conjunction with Montana Botanical Analysis
- uploaded to this post
"Chemistry and Analysis of Phytocannabinoids and Other Cannabis Constituents"
Rudolf Brenneisen
From: Forensic Science and Medicine: Marijuana and the Cannabinoids
- uploaded to this post
"Chemical constituents of marijuana: The complex mixture of natural cannabinoids"
Mahmoud A. ElSohly and Desmond Slade
Life Sciences 78 (2005) 539–548
- uploaded to this post
[not so...] "Recent Developments in Cannabis Chemistry"
ALEXANDER T. SHULGIN, Ph.D.
Journal of Psychedelic Drugs, vol. II, no. 1 (1971)
- uploaded to this post
"Human Studies of Cannabinoids and Medicinal Cannabis"
P. Robs on
HEP (2005) 168:719–756
- uploaded to this post
2. Endocannabinoid system and cytokine network:
"Cannabinoids, Immune System and Cytokine Network"
Massi, P.1; Vaccani, A.1; Parolaro, D.1
Current Pharmaceutical Design, Volume 12, Number 24, August 2006 , pp. 3135-3146(12)
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4051350&postcount=21
"The Cannabinoid System and Cytokine Network"
Thomas W. Klein, Brian Lane, Catherine A. Newton, Herman Friedman
Proceedings of the Society for Experimental Biology and Medicine
Volume 225, Issue 1, pages 1–8, October 2000
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4051350&postcount=21
"THE ENDOCANNABINOID SYSTEM AND ITS THERAPEUTIC EXPLOITATION"
Vincenzo Di Marzo,Maurizio Bifulco and Luciano De Petrocellis
NATURE REVIEWS, VOLUME 3, SEPTEMBER 2004
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4051350&postcount=21
"The Endocannabinoid System and the Therapeutic Potential of Cannabinoids"
Billy R. Martin
From: Forensic Science and Medicine: Marijuana and the Cannabinoids
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4051350&postcount=21
"THE NEURONAL, ENDOCRINE, METABOLIC EFFECTS OF ENDOCANNABINOID SYSTEM AND THE POTENTIAL CLINICAL IMPLICATIONS OF THE CANNABINOID TYPE 1 (CB1) BLOCKER"
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, Vol. 29, Suppl. to No. 3 (2006)
- Includes the following studies:
- "The chemistry of endocannabinoids". N.M. Kogan, and R. Mechoulam.
- "Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance". I. Matias, and V. Di Marzo
- "Neuromodulatory functions of the endocannabinoid system". G. Marsicano, and B. Lutz
- "Endocannabinoids and the gastrointestinal tract". F. Massa, and K. Monory
- "Endocannabinoids and energy metabolism". U. Pagotto, and R. Pasquali
- "Endocannabinoids as novel mediators of liver diseases". A. Mallat, and S. Lotersztajn
- uploaded to the following Russian file host, it's a good idea to disable JavaScript when downloading to prevent ads and other JS junk, passphrase is "ilovecanna" (without quotes): http://www.file-upload.net/download-3072038/chemistry.zip.html
3. Cannabinoids: THC, CBD, etc (natural and synthetic):
"Pharmacological Actions of Cannabinoids"
R. G. Pertwee
Cannabinoids, Handbook of Experimental Pharmacology, 2005, Volume 168, 1-51
- uploaded here: https://www.icmag.com/ic/showpost.php?p=4051350&postcount=21
"The acute effects of synthetic intravenous D9-tetrahydrocannabinol on psychosis, mood and cognitive functioning"
P. D. Morrison, V. Zois, D. A. McKeown, T. D. Lee, D. W. Holt, J. F. Powell, S. Kapur and R. M. Murray
Psychological Medicine (2009), 39, 1607–1616
- I have always thought about I.V. THC extract would be very useful for some very sick people, Sam Skunkman has written I.V. of THC has no affect, after reading this paper I am not sure Sam is correct...
- uploaded to this post
"A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol"
Ethan Russo and Geoffrey W. Guy
Medical Hypotheses (2006) 66, 234–246
- This paper is one of the bases for "Sativex", from GW Pharmaceuticals with the assistance of HotraPharm BV (for triploid cannabis plants from seed - which HotraPharm BV terms "clones", growing info, etc); Sativex is marketed by Beyer Drugs for GW Pharmaceuticals. Sativex is 50/50 THC/CBD IIRC.
- upload to this post
"Does cannabidiol protect against the negative effects of THC?"
Cécile Henquet and Rebecca Kuepper
The British Journal of Psychiatry, (2010) 197: 259-260
- uploaded to this post
"Cannabidiol potentiates pharmacological effects of D9-tetrahydrocannabinol via CB1 receptor-dependent mechanism"
Kazuhide Hayakawaa, Kenichi Mishimaa, Mai Hazekawaa, Kazunori Sanoa, Keiichi Iriea, Kensuke Oritoc, Takashi Egawaa, Yoshihisa Kitamuraa, Naoki Uchidad, Ryoji Nishimurad, Nobuaki Egashiraa, Katsunori Iwasaki and Michihiro Fujiwara
BRAIN RESEARCH 1188 (2008) 157 – 164
- uploaded to this post
OK, I ran out upload space in this post, I will continue with uploading studies in my next post. Please do not respond to this thread until I am done uploading studies, thanks
great links!
