medicated water based liquids

[RaminarDixon]

hey guys, I'm currently making some medicated sugar using decarb'd winterized oil (edible oil) and ethanol as a carrier solvent. the sugar comes out looking great, but when mixed with water, either in kool aid or tea of coffee etc.. the oil starts to come out of solution, and I notice a film forming on the top of the liquid. Is there an emulsifier such as PEG or something of that nature that would be suitable for premixing water based drinks and give them a shelf life? anybody know what dixie elixirs uses for their emulsifier? I want to stay away from ethanol, thanks.

 

[trichrider]

i do not.
but i can suggest lecithin .

LECITHIN Overview Information

Lecithin is a fat that is essential in the cells of the body. It can be found in many foods, including soybeans and egg yolks. Lecithin is taken as a medicine and is also used in the manufacturing of medicines.

Lecithin is used for treating memory disorders such as dementia and Alzheimer’s disease. It is also used for treating gallbladder disease, liver disease, certain types of depression, high cholesterol, anxiety, and a skin disease called eczema.

Some people apply lecithin to the skin as a moisturizer.

You will often see lecithin as a food additive. It is used to keep certain ingredients from separating out.

You may also see lecithin as an ingredient in some eye medicines. It is used to help keep the medicine in contact with the eye’s cornea.

How does it work?

Lecithin is converted into acetylcholine, a substance that transmits nerve impulses.

http://www.webmd.com/vitamins-suppl...ngredientId=966&activeIngredientName=LECITHIN

Food additive

The nontoxicity of lecithin leads to its use with food, as an additive or in food preparation. It is used commercially in foods requiring a natural emulsifier or lubricant.
In confectionery, it reduces viscosity, replaces more expensive ingredients, controls sugar crystallization and the flow properties of chocolate, helps in the homogeneous mixing of ingredients, improves shelf life for some products, and can be used as a coating. In emulsions and fat spreads, it stabilizes emulsions, reduces spattering during frying, improves texture of spreads and flavour release. In doughs and bakery, it reduces fat and egg requirements, helps even distribution of ingredients in dough, stabilizes fermentation, increases volume, protects yeast cells in dough when frozen, and acts as a releasing agent to prevent sticking and simplify cleaning. It improves wetting properties of hydrophilic powders (e.g., low-fat proteins) and lipophilic powders (e.g., cocoa powder), controls dust, and helps complete dispersion in water.[16] Lecithin keeps cocoa and cocoa butter in a candy bar from separating. It can be used as a component of cooking sprays to prevent sticking and as a releasing agent. In margarines, especially those containing high levels of fat (>75%), lecithin is added as an 'antispattering' agent for shallow frying.[17]
Lecithin is approved by the United States Food and Drug Administration for human consumption with the status "generally recognized as safe". Lecithin is admitted by the EU as a food additive, designated as E322.[18]
https://en.wikipedia.org/wiki/Lecithin

 

[tech1234]

hey guys, I'm currently making some medicated sugar using decarb'd winterized oil (edible oil) and ethanol as a carrier solvent. the sugar comes out looking great, but when mixed with water, either in kool aid or tea of coffee etc.. the oil starts to come out of solution, and I notice a film forming on the top of the liquid. Is there an emulsifier such as PEG or something of that nature that would be suitable for premixing water based drinks and give them a shelf life? anybody know what dixie elixirs uses for their emulsifier? I want to stay away from ethanol, thanks.

I do not know what dixie uses but this works great (after at least 30 test runs to perfect)

1 part bho
3 parts D-limonene
6 parts ethanol

heat bho and D-limonene to 120f mix and stir. It will instant dissolve. (unlike at room temp) add ethanol. add water based products. Enjoy

 

[TheArchitect]

Abstract
The purpose of the present study was to develop novel cyclodextrin-containing sublingual formulations of cannabinoids. Complexation of model cannabinoids, Delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD), with randomly methylated beta-cyclodextrin (RM-beta-CD) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD), were studied by the phase-solubility method. Due to better complexation efficiency, RM-beta-CD was selected for further studies. Solid THC/RM-beta-CD and CBD/RM-beta-CD complexes were prepared by freeze-drying. The dissolutions of both THC and CBD in the presence and absence of RM-beta-CD were determined. THC was selected for in vivo studies: the pharmacokinetics of THC after both sublingual and oral administrations of ethanolic THC and THC/RM-beta-CD complex solutions were studied in rabbits. The aqueous solubility of CBD and THC increased as a function of CD concentration, showing A(L)- and A(P)-type diagrams for HP-beta-CD and RM-beta-CD, respectively. Dissolution rates of THC/RM-beta-CD and CBD/RM-beta-CD complexes were significantly (p < 0.05) higher than those of plain THC and plain CBD, respectively. The absolute bioavailability (F) of THC decreased in the following order: sublingual THC/RM-beta-CD solution (F = 12.1+/-1.4%; mean+/-S.D.; n = 4) > oral THC/RM-beta-CD solution (F = 4.0+/-6.0%) > or = sublingual ethanolic THC solution (F = 3.8+/-2.8%) > oral ethanolic THC solution (F = 1.3+/-1.4%). These results demonstrate that RM-beta-CD increases both the aqueous solubility and dissolution rate of these cannabinoids, making the development of novel sublingual formulation possible. These results also suggest that the sublingual administration of a THC/RM-beta-CD complex substantially increases the bioavailability of THC in rabbits.

The present invention describes the use of natural cyclodextrins (α-CD, β-CD and γ-CD) in sublingual and buccal formulations in order to improve the dissolution rate and bioavailability of selected cannabinoids, especially classical cannabinoids such as cannabidiol (CBD), cannabinol (CBN) and Δ9-tetrahydrocannabinol (THC).


Cyclodextrins (CDs) are cyclic oligosaccharides consisting of (α-l,4)-linked α-D- glucopyranose units, with a lipophilic central cavity and a hydrophilic outer surface (Frδmming and Szejtli, 1994). CDs are able to form inclusion complexes with many drugs by taking up the whole drug, or more commonly, the lipophilic moiety of the molecule, into the cavity. The most abundant natural CDs are α- cyclodextrin (α-CD), β-cyclodextrin (β-CD) and γ-cyclodextrin (γ-CD), containing six, seven, and eight glucopyranose units, respectively. Of these three CDs, β-CD appears to be the most useful pharmaceutical complexing agent because of its cavity size, availability, low cost and other properties. There are also a number of CD derivatives available, such as hydroxypropyl-β-CD and methylated CDs. One of the major differences between natural CDs and the CD derivatives above is that natural CDs have been shown to form low solubility complexes with various drugs, as opposed to water-soluble CDs derivatives. Water-soluble CD derivatives form only water-soluble complexes with lipophilic drugs.

In drug formulations, CDs have been used mainly to increase the aqueous solubility, stability and bioavailability of various drugs, food additives and cosmetic ingredients (Fromming and Szejtli, 1994). In addition, CDs can also be used to convert liquid compounds into microcrystalline powders, prevent drug-drug or drug-additive interactions, reduce gastro-intestinal or ocular irritation, and reduce or eliminate unpleasant taste and smell.

Studies dealing with the use of CDs with cannabinoids (classical, non-classical and aminoalkylindol derivatives) are referred to in the following publications. Shoyama et al. (1983) have reported that THC forms an inclusion complex with natural β- CD with increasing chemical stability of THC. Shoyama et al. (1983) prepared the solid THC/β-CD inclusion complex by mixing THC and β-CD in a methanol/water solution and hypothesised that CDs (in general) may also be used to improve the aqueous solubility, membrane permeability and bioavailability of THC. Jarho et al. (1998) have reported that HP-β-CD increases the aqueous solubility of THC and co-administration of small amounts of water-soluble polymer (HPMC) enhances the complexation between HP-β-CD and THC. In addition, Song et al. (2000) and Porcella et al. (2001) have recently used HP-β-CD to solubilize the aminoalkylindol derivative WIN-55212 in topical ophthalmic formulations.





EXAMPLE 1

In this example the effect of natural β-CD on the dissolution characteristics of CBD have been described .

A powder containing a CBD/β-CD inclusion complex was prepared by the precipitation method. In this method a methanol solution of CBD was added dropwise to an aqueous β-CD solution and after equilibration the white precipitate (CBD/β-CD inclusion complex) was isolated and dried. The HPLC analysis of the powder showed that 9.1 mg of the powder contained 1.0 mg of CBD. All the following dissolution experiments were made in 2% RM-β-CD dissolution medias (pH 6.6) to ensure the free solubility of CBD.

Figure 1 shows the dissolution profile (dissolved CBD as a function of time) of CBD from a gelatine capsule containing 1.0 mg of pure CBD and 99 mg of lactose (Mean +_ SD, n=6). Figure 2 shows the same data with a capsule containing 9.1 mg of natural β-CD/CBD-complex (equivalent to lmg of THC) and 90.9 mg of lactose (Mean +. SD, n=4).

Figures 1 and 2 show that the complexation of CBD with natural β-CD significantly increases the dissolution rate of CBD. With a β-CD/CBD formulation, CBD is fully dissolved in 30 minutes. Without β-CD, the dissolution rate is much slower and CBD is not fully dissolved in 3 hours.

Delta9-tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L. and its therapeutic effects are currently under intensive study. However, THC has a very low aqueous solubility (1-2 microg/mL), which restricts its use as a pharmaceutical. The present study demonstrates that THC forms a drug-cyclodextrin complex in an aqueous solution of hydroxypropyl-beta-cyclodextrin (HP-beta-CD), resulting in a thousand-fold increase in THC solubility. This improvement in solubility can be further increased by adding 0.1% hydroxypropylmethylcellulose to the HP-beta-CD solution. The present results suggest that the use of cyclodextrins might be a simple and useful method to overcome the poor water solubility of THC.

that should be enough to get you started....

 

[aridbud]

LocDog, one of our members, uses lecithin with excellent results. Give it a try.

 

[beuno-medibles]

do a research on xanthan gum, will solve all your problems!

we use this stuff so much in molecular gastronomy that is no even funny!

some amazing properties on this stuff!

also, i would recomend you to look into MCT oil, the medium chain fatty acid's from coconut oil are pretty intersting to. when you figure it out how to use it the sky is the limit!

keep growing, keep processing and keep cooking!

 

[beuno-medibles]

@tech1234

i like your style bro!
just one question, why dont you use d-limonene to extract instead of using butane?

 

[tech1234]

@tech1234

i like your style bro!
just one question, why dont you use d-limonene to extract instead of using butane?

I get it already extracted...