Is THIS the Holy Grail??

[Seal-Clubber]

I have been reading recent studies involving these microscopic things called chromosomes, more specifically, a region of repetitive nucleotide sequences called Telomeres.

Basically, there are about a few hundred thousand of these repeating DNA sequences at the ends of every repeating DNA chain. This repetition is responsible for life and death of a repeating DNA chain. Every time a chromosome reproduces, it`s telomeres are reduced by a few hundred. Over the period of about 80-100 years, our telomeres are so short, they can no longer help a cell divide without complete nucleotide decomposition.

New studies are being produces which show the infusion of certain chemicals found in meat, the natural shortening of chromosomal telomere length is significantly reduced. Some reports are showing the detoxification of telomere apoptosis can be reduced but this leads to the possible effect of nucleic mutation (cancer). It will be corrected in the next 50 years.

Anyone have any thoughts? Do most of you understand that cancer is immortal? As long as it gets energy, it can live forever. Programming a cell to think it`s immortal, like cancer, is going to be possible.

In the early 1970s, Russian theorist Alexei Olovnikov first recognized that chromosomes could not completely replicate their ends. Building on this, and to accommodate Leonard Hayflick's idea of limited somatic cell division, Olovnikov suggested that DNA sequences are lost every time a cell/DNA replicates until the loss reaches a critical level, at which point cell division ends.[3][4]
In 1975–1977, Elizabeth Blackburn, working as a postdoctoral fellow at Yale University with Joseph Gall, discovered the unusual nature of telomeres, with their simple repeated DNA sequences composing chromosome ends. Their work was published in 1978. The telomere-shortening mechanism normally limits cells to a fixed number of divisions, and animal studies suggest that this is responsible for aging on the cellular level and sets a limit on lifespans. Telomeres protect a cell's chromosomes from fusing with each other or rearranging—abnormalities that can lead to cancer—and so cells are destroyed when their telomeres are consumed. Most cancers are the result of "immortal" cells that have ways of evading this programmed destruction.[5]
Elizabeth Blackburn, Carol Greider, and Jack Szostak were awarded the 2009 Nobel Prize in Physiology or Medicine for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.[6]

BUT You might find this MORE interesting..
http://www.ncbi.nlm.nih.gov/pubmed/15474517

Abstract

Telomere is the repetitive DNA sequence at the end of chromosomes, which shortens progressively with cell division and limits the replicative potential of normal human somatic cells. L-carnosine, a naturally occurring dipeptide, has been reported to delay the replicative senescence, and extend the lifespan of cultured human diploid fibroblasts. In this work, we studied the effect of carnosine on the telomeric DNA of cultured human fetal lung fibroblast cells. Cells continuously grown in 20 mM carnosine exhibited a slower telomere shortening rate and extended lifespan in population doublings. When kept in a long-term nonproliferating state, they accumulated much less damages in the telomeric DNA when cultured in the presence of carnosine. We suggest that the reduction in telomere shortening rate and damages in telomeric DNA made an important contribution to the life-extension effect of carnosine.

 

[benzo]

All I know is :
A --> T
C --> G



But thanks for the post, the world in 50 years from now is going to be a very different place. Can't wait

 

[lost in a sea]

telomere shortening leads to cell senesence and limits the amount of times DNA can copy itself.. which is what it basically says in those quotes.. stress hormones damage telomeres alot as well..

 

[Seal-Clubber]

currently a med-school student. I read and think about all kinds of things, even calculus, in my 'off' time.!



...just imagine, is humanity ready to live longer?

 

[strass]

What if cannabis delays this? Just my crazy stoner talk. Nevermind.

I was expecting some new strain info.

 

[Seal-Clubber]

cannabis has been shown to reduce/slow cancer cell growth, maybe cannabis can halt cancers ability to progress into the form which can evade apoptosis.

maybe that is one of the keys in preventing telomere preservation accompanied by cancer growth. more chemicals is obviously a bad piece of mind, but constructed appropriately, we might help to unlock more keys in the deliverance of humanity. Spliff-to-That!

 

[mean mr.mustard]

I know I don't want to live forever, but I'm sure that many do.

I can't wait until we run out of senior housing...

just imagine, is humanity ready to live longer?

My magic 8 ball says "outlook not so good".

 

[strass]

Who would want to live forever tho. I sure wouldnt.

 

[Hammerhead]

that depends what kind of life I had. In this life not a chance. If I was Huge Hefner maybe lol...

 

[strass]

that depends what kind of life I had. In this life not a chance. If I was Huge Hefner maybe lol...

Do you think Hefner really is that happy?

 

[Seal-Clubber]

I can't wait until we run out of senior housing...



View Image

My magic 8 ball says "outlook not so good".

Average life-span is 500 years old and the retirement age is 65. hahaha... Oh yeah.. with our going indulgence rates and disconcerting toward the future of humanity, employment, and capitalization governing bodies, I think we are going to see that nuke picture again. lol

 

[trichrider]

but isn't the dna sequence replicated in the new cells???

 

[Seal-Clubber]

but isn't the dna sequence replicated in the new cells???

Saddly, this is one of the hurdles of progression. When you find one key, others emerge. Telomeres do not re-sequence, this is why they must be preserved. Basically, they are the "capped ends" of DNA chains and everything inside of them is replicated until mutation and/or breakdown occurs.

 

[trichrider]

so each cell division reduces the length of the telomeres and the dna chain is not replicated in toto?

 

[k-grower]

i like to think that everyone of us is just form of energy in transition to other type of energy, i think nothing gets lost as in the original budhism what gautama siddharta wrote, science may not prove it yet but i think it will someday.
i never want to be immortal, i mean it would be fun first 1000 years but then it would lost shine in some point and the weight of knowledge and frustration would do life very agonizing, + the fact that we cant even now feed everyone in this planet, we would have to colonize space or live on small cubicles stacked on each other on sky high to have room, if everyone would be immortal

 

[ghostly]

Is THIS the Holy Grail??

i like to think that everyone of us is just form of energy in transition to other type of energy, i think nothing gets lost as in the original budhism what gautama siddharta wrote, science may not prove it yet but i think it will someday.
i never want to be immortal, i mean it would be fun first 1000 years but then it would lost shine in some point and the weight of knowledge and frustration would do life very agonizing, + the fact that we cant even now feed everyone in this planet, we would have to colonize space or live on small cubicles stacked on each other on sky high to have room, if everyone would be immortal

The myth of scarcity is just that, a myth. It's the "shytstem' the planet cannot sustain- the way we exist. Our planet could support many times the number of creatures it holds today but it must be done in a way that balances nature, not in an artificial and non-sustainable manner.

 

[k-grower]

The myth of scarcity is just that, a myth. It's the "shytstem' the planet cannot sustain- the way we exist. Our planet could support many times the number of creatures it holds today but it must be done in a way that balances nature, not in an artificial and non-sustainable manner.

i wish it would be a myth, but if everyone would be immortal the space would end soon.
scarcity is not myth every second is one child dying on earth for lack of food, lot of information about that too...

 

[mpd]

I turn 51 next week. I've got arthritis, shingles, migraine headaches and I am (according to the state) insane. I'm not sure I want to live forever, but what if they could cure all these maladies and my quality of life was there? I'm telling you, as you get older the sanctity of your continued existence becomes more and more of an important topic you dwell on.

 

[Hammerhead]

Yes I do

 

[Seal-Clubber]

Our planet could support many times the number of creatures it holds today but it must be done in a way that balances nature, not in an artificial and non-sustainable manner.

No kidding, based on the animal instinct of human beings, I assume we lack this vital embrace of our surroundings. We have too much of the wars, anger, and rat-racing mentality. These are things of terror to the future of our people. We are NOT ready..