Hypothetically...

[514-Represent]

Big Mac. Roughly 1.5 feet in height. 600 watt in a sealed room. Lights 21 inches away from the tops. Botannicaire Pure Blend Pro w/ Liquid Karma.

2/6 of the plants developing tips have become mutated and somehow curled and burnt right off. Any ideas as to what might be causing this or how to control it?

 

[MTF-Sandman]

Temps?
RH?
Setup?
PPM & PH?
Medium?
PICS!?

 

[514-Represent]

29 lights on.
25 lights off.
30% RH.
Setup = 600 watt in a sealed room.
No ferts yet.
Soil based.

My camera sucks... sorry...

 

[514-Represent]

The upper part of the plants look mutated almost as if they aren't growing in properly. The look curled and twisted. I'm thinking maybe a PH problem?

 

[MTF-Sandman]

So what exactly is "soil based"? If you want any accurate help, you're gonna need to provide as many details as possible...especially with no pics. What's the NPK, what all is mixed in it (and how much), how often are they watered, etc...

It could easily be PH, or nute related. Have you checked MNS's sticky?