rkrone said:i use the machine gun, with armor piercing rounds, the RPG, but the crossbow with the trap bolts works the best imo, not only do they do damage upon impact but then they activate and electrocute them as well. armor piercing rounds work great if you havent gotten the stronger weapons. also use the electric plasmid to stun him, pop off a few rounds and repeat, sometimes they will charge but if you keep circle strafing you should be fine.....and dont feel bad i only killed about 4 big daddys without them killing me first, all the others took at least 1 life from me.
but i would have to say i used the chemical thrower the least out of all the weapons.