Duration of effects.

[Dime]

Anyone have thoughts on why some cannabis effects last a lot longer than others on properly grown plants ? I find most "pleasant high" varieties are short lived ex:an hour or so,anyone have recommendations on hard hitters with actual staying power that aren't sleep inducing? I switched to hash a long time ago and it seems to last quite a bit longer. Thx in advance for any replies.

 

[Creeperpark]

Anyone have thoughts on why some cannabis effects last a lot longer than others on properly grown plants ? I find most "pleasant high" varieties are short lived ex:an hour or so,anyone have recommendations on hard hitters with actual staying power that aren't sleep inducing? I switched to hash a long time ago and it seems to last quite a bit longer. Thx in advance for any replies.

That's a good question friend. If you are only smoking hash it will be hard to match that hash high without a period of "high fasting" for a few days.

 

[handwerker]

What you're experiencing is noticed and told by many oldschoolers; modern hybrids having shorter effects and the stone feels kinda same.
Reasoning is mostly money; weed got bred for shorter flowering times (8-10 weeks) resulting in more crops per year. Bag appeal and smell became more important than effect. Putting Skunk et al. in everything. High THC for the stats and dull high, ignoring thousands of other ingredients. Also the comedown became nasty / tiring. Not true for every plant but the broader market. What you're searching is there, you have to invest your time and grow it by yourself since not many will do the hassle for these long flowering ones. We are speaking of flowering times of min 12 weeks+ ... up to 22 .. Big plants with airy buds. Have a look for Haze & Thai. If you are a real hardcore purist you do them as landrace, but I guess F1 hybrid is fine.

I also asked ChatGPT and the answer ain't bad

"Cannabis plants have different flowering durations depending on their genetics, with some strains having longer flowering periods than others. The flowering duration refers to the amount of time it takes for the buds to fully develop and mature.

When it comes to the effects and duration of the cannabis experience, there are a few factors to consider:

1. Cannabinoid Levels: The primary cannabinoids in cannabis, such as THC and CBD, play a crucial role in determining the effects and duration of the high. Strains with longer flowering periods often have higher levels of cannabinoids, which can result in a more potent and longer-lasting experience.
2. Terpene Profiles: Terpenes are aromatic compounds found in cannabis that contribute to its flavor, aroma, and effects. Strains with longer flowering times tend to develop more complex terpene profiles, which can enhance the overall experience and potentially prolong the duration of the effects.
3. Maturation and Ripeness: Cannabis plants that have longer flowering periods have more time to fully mature and ripen. This extended growth phase allows the trichomes (the resin glands containing cannabinoids and terpenes) to fully develop and reach their peak potency. The increased maturation time can lead to a more intense and longer-lasting high.
4. Personal Factors: It's worth noting that individual reactions to cannabis can vary based on factors like tolerance, metabolism, and dosage. While longer flowering strains generally have the potential for longer-lasting effects, personal variations can still influence the duration experienced by different individuals.

It's important to remember that other factors, such as consumption method and dosage, can also impact the duration of the cannabis experience. " (e.g. eating is so much longer in duration)



they can fk up your sleep shedule ^^
racy
psychedelic
go for it!

 

[Piff_cat]

Cbc is responsible for keeping thc at site receptor for longer. It also stimulates sodium channels and increases production of andramine the bliss molecule. Cbt also formed thru cyclo addition of cbc or thc works synergistically.

Unfortunately most modern hybrids have a deletion of 8 cbc genes linked to 5 pathogen protection traits. This group of genes is called contig 756. Cbc is only produced in stalkless glandular trichomes aka peltate. These scale like trikes work with stomatas for gas exchange and battle fungi or bacyeria intruders in high humidity enviorments. Peltate are only found on sugar leAves stems much less on bud.
Since most hybrids come from drier hashplant areas the cbc defense system is bred out in a few domesticated henerations.

sesquiterpenes also made in peltate and act as bitter first defense against herbivores. Guiaol and beta carolyohene are 2 important sesquiterpenes for effect- bc activates cb2 receptor and guiaol known ti be powerful anti anxiety.

 

[MAHA KALA]

Anyone have thoughts on why some cannabis effects last a lot longer than others on properly grown plants ?

genetics.

I always thought tropical cultivars have long duration of effect, according to my experience with thaihaze which was selected at northern hemisphere.

I was in shock when I saw report on some current cambodian, 2 hours high only and munchies... not long ago I read description of nigerian silk :

"The effects of this particular strain, however, are quite short for only about an hour and a half. You feel it behind the eyes and it takes a little while for the Nigerian Silk strain to start having an effect on you."

thats bad for sativa. only hour and half, for me not worthy to grow.

so genetics and selection. shoot me pm and I give you recommendation for long lasting haze.

dutch haze hybrids are maximally two hours, if it is enough for you? only nevilles haze can reach 3 hours. more haze in hybrid = longer lasting.

nevilles haze

skunk haze, maximally 2 hours..

chocolate thai x haze, 4 - 5 hours

 

[Piecho]

Cbc is responsible for keeping thc at site receptor for longer. It also stimulates sodium channels and increases production of andramine the bliss molecule. Cbt also formed thru cyclo addition of cbc or thc works synergistically.

Unfortunately most modern hybrids have a deletion of 8 cbc genes linked to 5 pathogen protection traits. This group of genes is called contig 756. Cbc is only produced in stalkless glandular trichomes aka peltate. These scale like trikes work with stomatas for gas exchange and battle fungi or bacyeria intruders in high humidity enviorments. Peltate are only found on sugar leAves stems much less on bud.
Since most hybrids come from drier hashplant areas the cbc defense system is bred out in a few domesticated henerations.

sesquiterpenes also made in peltate and act as bitter first defense against herbivores. Guiaol and beta carolyohene are 2 important sesquiterpenes for effect- bc activates cb2 receptor and guiaol known ti be powerful anti anxiety.

Interesting! Do you have any papers on that? Always happy to educate, but I did not found much about CBC and THC interaction myself.

 

[Deleted user 4684842]

Cbc is responsible for keeping thc at site receptor for longer. It also stimulates sodium channels and increases production of andramine the bliss molecule. Cbt also formed thru cyclo addition of cbc or thc works synergistically.

Unfortunately most modern hybrids have a deletion of 8 cbc genes linked to 5 pathogen protection traits. This group of genes is called contig 756. Cbc is only produced in stalkless glandular trichomes aka peltate. These scale like trikes work with stomatas for gas exchange and battle fungi or bacyeria intruders in high humidity enviorments. Peltate are only found on sugar leAves stems much less on bud.
Since most hybrids come from drier hashplant areas the cbc defense system is bred out in a few domesticated henerations.

sesquiterpenes also made in peltate and act as bitter first defense against herbivores. Guiaol and beta carolyohene are 2 important sesquiterpenes for effect- bc activates cb2 receptor and guiaol known ti be powerful anti anxiety.

"It also stimulates sodium channels and increases production of andramine the bliss molecule."
I believe you meant anandamide.

"Cbc is responsible for keeping thc at site receptor for longer."
This sounds interesting. Do you have a source for this?

Caryophyllene was one of my first guesses too. It's the dominant terpene in Kali Mist and it's been a while but I believe I've experienced some longer durations of high with Kali Mist. And like you said, it's a CB2 agonist and I believe the only terpene which is also a cannabinoid.

This might be a stretch but maybe a small amount of CBD could prolong the high? It inhibits THC metabolism thus keeping THC in your system longer, I think. I think this action might be negligible but maybe it's a possibility.

Guaiol wasn't on my radar at all. That sounds interesting.

What about nerolidol? It's just a hunch but nerolidol seems like a possibility too. I once popped the lid on some Durban I had curing and there was just a flood of terpenes in the room and I think it was mostly nerolidol that I was smelling. Maybe it's just me but I recall getting a significant buzz just from the smell.

Could CBG play a role?

 

[Piecho]

In my experience mixing THC dominants and CBG ones ended with shorter, but more psyhodelic entourage effect.

 

[Deleted user 4684842]

In my experience mixing THC dominants and CBG ones ended with shorter, but more psyhodelic entourage effect.

Interesting. I feel like in some cases like maybe White Fire, CBG could contribute to a sedative effect whereas with Amnesia Haze it might contribute to a stimulant effect and maybe increase the duration. Hazes are known to have longer highs, I think, and they tend to be higher in CBG.

And speaking of entourage effects, occasionally I see test results showing like a dozen terpenes in equal amounts. Or once I saw test results for a sample of Grapefruit that showed significant amounts of damn near every cannabinoid. I wonder if having a greater number of terpenes and/or cannabinoids might prolong duration.

 

[Piff_cat]

heres some of the newer screenshot infos. big picture cbc and thc are referred to as "sister clades" synthase enzymes are 92 percent identical but the substances are very different. somehow there are over 40 cbc genes in cannabis genome as opposed to under 20 for thc. high cbc strains are found mainly in northeast asia and closely mirror the basal cannabis range found in 2019 genome study which runs from northwest china(xinijiang) all the way up to the shandong/inner mongolia/ heliojiang/korea "greater manchuria" sams company did a great research paper on an andong south korean "fibre" line with a chemotype of no cbd thc/cbc dominant with cbg monomethyl ether minor

the most recent info on receptors has found cbc to have alot more action with cb2 then previously thought. this is due to the racemic nature of cbc- it has 2 different isomers and one has a ton more cb2 interaction then the other. so theres alot to untangle there

sams andong line

 

[Deleted user 4684842]

@Piff_cat One of your citations mentions CBGM. Do you know anything abut it? I used to love Lowryder 2, which had a decently long high by the way, and I think it may have had a fair amount of CBGM. I know CBGM was identified in Japanese hemp and so on but I haven't seen much written about its effects or mechanism of action. I never ever see it in test results for any strain and I've never seen it available in isolate form.

This is very anecdotal but it seems like some Thai hybrids I've had were higher in CBC and would sometimes give me a feeling of pressure in my temples, sometimes not very pleasant, almost like CBN or something. I've wondered about this for years but maybe that had nothing to do with CBC.

 

[Piecho]

heres some of the newer screenshot infos.

Thanks! Can you share the titles of the publications? I prefer to check with the full context : )

 

[El Timbo]

The longest lasting high I've had in recent years was Malawi x Panama