Cbd alchemyy

[Spinme]

What would the legalities be on growing high cbd hemp....
Then moving said harvest to a state like Colorado or Oregon...
Extracting all the cbd..
Then isomerizing it to red thc oil......
Separating the remaining cbd...
Then selling the thc oil to the medical or recreational markets.
Could someone liscensed to do concentrates perform these reactions legally?
I know they can make crystalline . Thca
This is similar chemistry.....,.....but much more simple.
.........maybe its a pipe dream..... I'm not trying to be involved in manufacturing but there are a lot of laws in play that make all of the steps legal in one way or another.......any thoughts on this would be welcome.
A hemp field produces an aweful lot of cbd Wich is the perfect candidate for isomerization to it's other isomer thc

 

[slant.i]

I think it would depend on the exact process of isomerizing CBD to THC in terms of legalities. I would think a lab licensed for cannabis hydrocarbon extraction would be allowed to in terms of the law. However, gearing up with listed and approved equipment that would meet the requirements of the law would seem to pose quite a few problems. Namely, where do you source an approved system that is big enough to match your desired capacity? I'm not totally sure that is currently possible without investing a lot of time and money into R&D.

Probably your biggest problem is trying to compete with current market prices. Right now, in CA at least, THC distillate is cheap and abundant. I can't really imagine how it'd be possible to beat the price with the added step of isomerization, as your still extracting to crude then distilling whether CBD or THC.

And then if they really do succeed with the THC producing yeast... it'll be game over for you even if you were able to successfully get up and running.

Keep in mind that the supply side of THC is currently kept lower by federal prohibition as well. If it does go federal in the next 5-10 years that will probably really change things up.


It's a super cool idea though. I personally think my time will be better invested in studying chemistry and getting a degree, so which ever way the market ends up going I'll be much more prepared to take advantage of the opportunities. Who knows though, so much has changed in the last 10 years that I've been involved, and I don't imagine it's stopping anytime soon.

I definitely think there is something there in the isomerization of cannabinoids. Maybe not CBD > THC, but if you are well versed in how to create some of the more rare ones, it seems like it wouldn't be hard to monetize that skill.

 

[Spinme]

Isomerization is simple.
Acidify with sulphuric cid....
Reflux for two hours or so
Nutralized with sodium hydroxide is a simple way... Old school about 70 percent thc from cbd

 

[slant.i]

I suppose you could probably just use basic chemistry glass for the reaction, but in order to do the volume necessary to keep up with the market I would think it might be necessary to have specialized gear. What sort of equipment do you need?

Even if it is a simple process, I'm not sure cbd is that much cheaper than thc, if at all in some places. Doesn't give you much room to account for the added overhead costs, like the chemicals needed and the transportation and storage. Depending on how far and how much, probably won't be cheap.

 

[Spinme]

You are probably right. I'm just scheming.
My parrents are pretty old I'm thirty.. they just gave me permission to farm hemp so I'm trying to study the inns and outs.. peace
Trix

 

[Gray Wolf]

Sweet Mary’s Charms III

Another thank you to Dr. Justin Fischedick for the pile-o-papers and studies, in support of my quest to solve the CBN riddle, and the study done by Rajk K. Rasdan titled "The Total Synthesis of Cannabinoids". Published by the Department of Chemistry, Carlton University’s “Total Synthesis of Natural Products. Available on line at:

https://onlinelibrary.wiley.com/doi/1...78.ch2/summary

Also (thank you SkyHighler) at:

Link to a free download via Library Genius (click on 'GET')

https://libgen.io/scimag/ads.php?doi=10.1002%2F9780470129678.ch2&downloadname=

Hee, hee, hee, snicker, snark snort, this paper reviews multiple processes for producing the cannabinoids out of other readily available terpenes.

Not just the d9-THC and CBD that has the rapt attention of the populous, but some that are harder to acquire in large quantities and which have their own medicinal properties.

What a boon to cannabis medical research!!!

Here is a taste:

The Total Synthesis of Cannabinoids​

by​

Rajk. Razdan​

SISA Incorporated, Cambridge, Mass.​

[FONT=&quot]1. [/FONT][FONT=&quot]Introduction[/FONT]
[FONT=&quot]2. [/FONT][FONT=&quot]Strategy in the Synthesis of (-)-ts6-THC[/FONT]’[FONT=&quot]s and their Metabolites[/FONT]
[FONT=&quot]A. [/FONT][FONT=&quot]Synthesis ot t1- and ts6-THCs[/FONT]
[FONT=&quot]B. [/FONT][FONT=&quot]Synthesis of cis-THCs[/FONT]
[FONT=&quot]C. [/FONT][FONT=&quot]Metabolites of Tetrahydrocannabinols[/FONT]
[FONT=&quot]D. [/FONT][FONT=&quot]Metabolites Funtionalized in the Alicyclic Ring[/FONT]
[FONT=&quot]E. [/FONT][FONT=&quot]Metagolites Functionalized in the Aromatic Ring[/FONT]
[FONT=&quot]3. [/FONT][FONT=&quot]Synthesis of Other THC[/FONT]’[FONT=&quot]s and Related Cannabinoids[/FONT]
[FONT=&quot]A. [/FONT]“[FONT=&quot]Unnatural[/FONT]”[FONT=&quot] THCs[/FONT]
[FONT=&quot]B. [/FONT][FONT=&quot]Cannabidiols[/FONT]
[FONT=&quot]C. [/FONT][FONT=&quot]Cannabinol[/FONT]
[FONT=&quot]D. [/FONT][FONT=&quot]Cannabinolic Acids[/FONT]
[FONT=&quot]E. [/FONT][FONT=&quot]Cannabigerol[/FONT]
[FONT=&quot]F. [/FONT][FONT=&quot]Cannabichromene[/FONT]
[FONT=&quot]G. [/FONT][FONT=&quot]Cannabicyclol[/FONT]
[FONT=&quot]H. [/FONT][FONT=&quot]Novel Cannabinoids[/FONT]
[FONT=&quot]4. [/FONT][FONT=&quot]New Cannavinoid Transformations[/FONT]
[FONT=&quot]A. [/FONT][FONT=&quot]Photochemical[/FONT]
[FONT=&quot]B. [/FONT][FONT=&quot]cis+trans Conversion[/FONT]
[FONT=&quot]C. [/FONT][FONT=&quot]Pyrolysis[/FONT]
[FONT=&quot]5. [/FONT][FONT=&quot]Synthesis of THC Analogs[/FONT]
[FONT=&quot]A. [/FONT][FONT=&quot]Carbocyclic Analogs[/FONT]
[FONT=&quot]B. [/FONT][FONT=&quot]Heterocyclic Analogs[/FONT]
[FONT=&quot]6. [/FONT][FONT=&quot]Overall Structure-Activity Relationships in Cannabinoids[/FONT]
[FONT=&quot]7. [/FONT][FONT=&quot]Therapeutic Indications and potential of New Drugs from Cannabinoids[/FONT]

 

[Spinme]

I worked with an ex cia chemist who turned into a crazy tweaker from doing work in Columbia in the eighties who showed me a cool the synth.
Ruthenium catalyst
Olivetolic
And any six sided aromatic ring ... Benzene ring
Catalyzed reaction called closed ring metathesis
Pretty cool alchemy.
When he published the synth in the eighties they permanently froze his bank accounts he get tweaked out and stayed that way until he died a year ago.
My organ chem teacher....
RIP....four years one on one raining.
I'm not a genius but I have performed 6 stage synths first time before. Not best yeilds but ok..

 

[slant.i]

GW- That is awesome... have you performed any of these synthesis?

Definitely on the list of things to try once I get some money and a little area to play in..

 

[Gray Wolf]

We did Isomerizing CBD to THC and converting THC to THC-O-A, but I didn't get the above study until after our lab was already closed.

Pharmer Joe made some other esters when we were experimenting with acedic anhydride, but I don't remember any details or anything special.

I'm in the process of updating our earlier experiments using concentrates, to using crystalline CBD and THC separately.

Once set up for that, I'll take another look at what else I can do.

 

[slant.i]

If you had to make a rough guess, what would you say is about the least someone could spend on lab gear to perform a reaction like CBD > THC or THC-O-A?

 

[Gray Wolf]

If you had to make a rough guess, what would you say is about the least someone could spend on lab gear to perform a reaction like CBD > THC or THC-O-A?

Looking at ball park budget numbers, the only expensive item is the stirring hotplate, which you can buy relatively cheap used off E-Bay. https://www.ebay.com/sch/i.html?_fr...RS0&_nkw=magnetic+stirring+hot+plate&_sacat=0

Chemical goggles, <$10, respirator <$20, water pump <$25, 5 gallon bucket <$5,thermometer, pipettes, hoses, etc <$25. .

Separatory funnel <$25.

A boiling flask, alihin condenser, magnetic stir bar, should be available off ebay for less than about <$100