Edi, so some plants are in perlite and others are in perlite/coco? Are you seeing problems with both or only perlite/coco ? It usually helps to give as much info as you can. Feeding with what exactly? Have u grown this way succesfully before?
Looks like lockout/deficiency to me. But this is merely a guess and nothing more. Not familiar with this style of growing.
KushKrusher, to me it looks like a pest problem. Anything crawling under the leaf? Flying around the plant?